Patents by Inventor Herbert Chen

Herbert Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8338482
    Abstract: Methods and pharmaceutical compositions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising increasing the levels or activities of Notch1 protein or other components of the Notch1 signaling pathway of the cancer cells. Also disclosed are pharmaceutical compositions for the methods.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: December 25, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Herbert Chen, Muthusamy Kunnimalaiyaan
  • Publication number: 20080045445
    Abstract: Methods and pharmaceutical compositions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising increasing the levels or activities of Notch1 protein or other components of the Notch1 signaling pathway of the cancer cells. Also disclosed are pharmaceutical compositions for the methods.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 21, 2008
    Inventors: Herbert Chen, Muthusamy Kunnimalaiyaan
  • Publication number: 20060121040
    Abstract: Methods and pharmaceutical compostions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising inhibiting the activities of GSK-3? of the cancer cells. Also disclosed are pharmaceutical compositions for the methods. Preferably, the pharmaceutical composition comprises Li+, SB216763, SB415286, indirubins, Paullones, Hymenialdisine, Azakenpaullone, Thienyl and phenyl ?-halomethyl ketones, CHR 99021, AR-A014418, Bis-7-azaindolylmaleimides, CHR 98023, CHR-98014, and ZM336372, or a pharmaceutically acceptable salt or derivative thereof.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 8, 2006
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Muthusamy Kunnimalaiyaan, Herbert Chen
  • Publication number: 20060025485
    Abstract: The present invention provides for the treatment of cancers, particularly neuroendocrine cancers, using the Raf-1 inducer ZM336372, or analogs thereof.
    Type: Application
    Filed: June 29, 2005
    Publication date: February 2, 2006
    Inventors: Kyle Holen, Herbert Chen, Jamie Van Gompel
  • Publication number: 20010004675
    Abstract: A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses.
    Type: Application
    Filed: September 21, 1998
    Publication date: June 21, 2001
    Inventors: JOHN C. WOODARD, SHELDON I. GREENBERG, RONALD A. NESS, RICHARD M. ROMLEY, THAN NGUYEN, HERBERT CHEN
  • Patent number: 6102845
    Abstract: A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: August 15, 2000
    Assignee: Baxter International Inc.
    Inventors: John C. Woodard, Ronald A. Ness, Richard M. Romley, Than Nguyen, Herbert Chen
  • Patent number: 6001056
    Abstract: A smooth-walled non-crimped inflow conduit for an implantable ventricular assist system. The conduit has an internally smooth lumen surface for enhanced washing of the conduit under irregular blood flow conditions. The conduit includes a tubular graft body that may be formed of a knitted fabric sealed with bovine collagen or gelatin, or formed of closed structured PTFE. The conduit may include external ribbing or support to prevent inward collapse under negative pressure conditions and also protect against damage from inadvertent physical contact in the operating room. The external support may be bonded to the exterior or formed integrally with the tubular graft body. An outer reinforcement cage may be provided to help prevent gross distortion or damage to the tubular graft body. The ends of the tubular graft body are left unsupported and wrapped around opposed lips of conduit coupling structure to minimize blood contacting surfaces at junctions with other conduits or with the heart.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: December 14, 1999
    Assignee: Baxter International Inc.
    Inventors: Jal S. Jassawalla, Herbert Chen, Donald T. Shannon
  • Patent number: 5810708
    Abstract: A ventricular assist device includes a pair of valved conduits and a pumping portion connected by these conduits into the circulatory system of a host patient. The pumping portion and valved conduits are constructed and configured to minimize the number of material-surface transitions which blood must cross in flowing through the device. Also, the valved conduits include porcine xenograft valves, which are externally supported by stenting structure located outside of the blood-contacting flow path of the device. A flexible shape-retaining inner wall member of the valved conduits is impervious to blood, but defines a porous inner surface on which a stable biological interface may form. Also, this inner wall member is shaped with sinuses which do not replicate either the porcine sinuses from which the xenograft valves were taken, or human aortic sinuses.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 22, 1998
    Assignee: Baxter International Inc.
    Inventors: John C. Woodard, Ronald A. Ness, Richard M. Romley, Than Nguyen, Herbert Chen
  • Patent number: 5599173
    Abstract: A pump system is described which is particularly suited for use as a left ventricular assist device for internal use in humans. The pump system generally includes a pump having a deformable sac formed in a seamless piece of flexible resilient material having (i) a pair of opposite substantially planar walls and of substantially circular shape joined by an annular wall of substantially semicircular cross-section and (ii) inlet and outlet means. The inlet means have an asymmetric tapered section positioned to direct the inlet flow toward the annular wall of the sac to produce a smooth circular flow within the sac and minimize thrombus formation. A pair of pusher plates are disposed on opposite sides of the sac. Each of the pusher plates are engageable with a respective one of the planar walls of the sac for displacing at least one of the planar walls toward the other to deform the sac. The pump system also includes removable inlet and outlet conduit means with valve means for controlling inlet and outlet flow.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 4, 1997
    Assignee: Baxter International, Inc.
    Inventors: Herbert Chen, Ronald A. Ness, John C. Woodard
  • Patent number: 5511958
    Abstract: A pump system is described which is particularly suited for use as a left ventricular assist device for internal use in humans. The pump system generally includes a pump having a deformable sac formed in a seamless piece of flexible resilient material having (i) a pair of opposite substantially planar walls and of substantially circular shape joined by an annular wall of substantially semicircular cross-section and (ii) inlet and outlet means. The inlet means have an asymmetric tapered section positioned to direct the inlet flow toward the annular wall of the sac to produce a smooth circular flow within the sac and minimize thrombus formation. A pair of pusher plates are disposed on opposite sides of the sac. Each of the pusher plates are engageable with a respective one of the planar walls of the sac for displacing at least one of the planar walls toward the other to deform the sac. The pump system also includes removable inlet and outlet conduit means with valve means for controlling inlet and outlet flow.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: April 30, 1996
    Assignee: Baxter International, Inc.
    Inventors: Herbert Chen, Ronald A. Ness, John C. Woodard
  • Patent number: 5199064
    Abstract: A single integrated circuit forms a hands-free telephone unit for use in a digital telephone network and in association with an external keypad, an external microprocessor, an external microphone, and an external speaker. The integrated circuit includes a keypad monitor arranged to provide digital key code signals, an audio processor for supporting hands-free operation, and a digital interface to provide a digital interface between the integrated circuit and the digital network and the external microprocessor.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: March 30, 1993
    Assignee: Advanced Micro Devices, Inc.
    Inventors: Dale E. Gulick, Herbert Chen, Alan F. Hendrickson
  • Patent number: 4581018
    Abstract: An improved implantable infusion device for delivering precisely regulated doses of fluid into the body of a patient is disclosed. The device utilizes a resilient non-compliant pump bellows that is directly coupled by a gear train to a motor. The bellows is biased toward the expanded position and this factor, combined with the mechanical inertia of the gear train, substantially eliminates the danger of an overdose of infusate being released into the patient.
    Type: Grant
    Filed: November 23, 1983
    Date of Patent: April 8, 1986
    Assignee: Novacor Medical Corporation
    Inventors: Jal S. Jassawalla, Herbert Chen
  • Patent number: 4557673
    Abstract: A chamber structure in a blood pump or the like is described. The structure includes a deformable sac having an annular side wall which is held in a rigid condition, and a pair of opposed circular walls, each joined to the annular side wall through a flexible annular wall portion. A circular pusher plate acting against each circular wall has an initial deflection position at which the associated flexible wall portion in the sac takes the form of a circumferentially uniform roll having an outwardly convex, bulged cross sectional curvature. The rolls in the sac maintain their circumferentially uniform, bulge-like character as the pusher plates are moved toward inwardly moved positions.
    Type: Grant
    Filed: October 17, 1984
    Date of Patent: December 10, 1985
    Assignee: Novacor Medical Corporation
    Inventors: Herbert Chen, Michael G. Conley
  • Patent number: 4142524
    Abstract: A cassette is described for use in an intravenous delivery system having a pump. The volume of a main chamber defined by the cassette body is varied by a membrane in a wall thereof while unidirectional inlet and outlet valves maintain the direction of fluid flow into and out of the main chamber. A prechamber is positioned above the inlet port in order to accumulate air from the upstream portion of the intravenous delivery system in which the cassette is used.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: March 6, 1979
    Assignee: Andros Incorporated
    Inventors: Jal S. Jassawalla, Herbert Chen, Ingvar Olaffson