Patents by Inventor Herbert de Groot

Herbert de Groot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9603354
    Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: March 28, 2017
    Assignee: DR. FRANZ KOEHLER CHEMIE GMBH
    Inventors: Herbert de Groot, Ursula Rauen, Gernot Koehler, Wilfried Bruns
  • Patent number: 8945611
    Abstract: The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: February 3, 2015
    Assignee: Universit├Ąt Duisburg-Essen
    Inventors: Herbert De Groot, Christian Mayer, Frank Petrat, Michael Kirsch
  • Publication number: 20110300237
    Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 8, 2011
    Inventors: Herbert de Groot, Ursula Rauen, Gernot Koehler, Wilfried Bruns
  • Publication number: 20110223243
    Abstract: The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
    Type: Application
    Filed: July 8, 2009
    Publication date: September 15, 2011
    Inventors: Herbert De Groot, Christian Mayer, Frank Petrat, Michael Kirsch
  • Patent number: 7977383
    Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: July 12, 2011
    Assignee: Dr. Franz Koehler Chemie GmbH
    Inventors: Herbert de Groot, Ursula Rauen, Gernot Koehler, Wilfried Bruns
  • Publication number: 20030215781
    Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
    Type: Application
    Filed: May 16, 2003
    Publication date: November 20, 2003
    Inventors: Herbert de Groot, Ursula Rauen, Gernot Koehler, Wilfried Bruns