Patents by Inventor Herbert Diehl

Herbert Diehl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
    Patent number: 7709644
    Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: May 4, 2010
    Assignee: LANXESS Deutschland GmbH
    Inventors: Herbert Diehl, Andreas Krebs, Elvira Krebs, legal representative, Walter Lange, Hanns-Ingolf Paul, Dietrich Seidel, Rolf Grosser, Tobias Reichelt
  • Process for preparing carbamic ester derivatives
    Publication number: 20080171891
    Abstract: An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.
    Type: Application
    Filed: March 18, 2008
    Publication date: July 17, 2008
    Inventors: Bettina HOLZER, Herbert DIEHL
  • Process for preparing carbamic ester derivatives
    Patent number: 7396952
    Abstract: An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: July 8, 2008
    Assignee: LANXESS Deutschland GmbH
    Inventors: Bettina Hölzer, Herbert Diehl
  • Process for preparing carbamic ester derivatives
    Publication number: 20070232825
    Abstract: An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.
    Type: Application
    Filed: December 6, 2005
    Publication date: October 4, 2007
    Inventors: Bettina Holzer, Herbert Diehl
  • Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
    Publication number: 20070213536
    Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
    Type: Application
    Filed: January 9, 2007
    Publication date: September 13, 2007
    Inventors: Herbert Diehl, Andreas Krebs, Elvira Krebs, Walter Lange, Hanns-Ingolf Paul, Dietrich Seidel, Rolf Grosser, Tobias Reichelt
  • Method for producing 8-methoxy-quinolinecarboxylic acids
    Patent number: 7115744
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: October 3, 2006
    Assignee: Bayer Healthcare Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Diehl
  • Preparation of 4-amino-1-naphthol ethers
    Publication number: 20050261498
    Abstract: The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl group is cleaved off, and further describes 4-acetamino-1-naphthol ethers obtained thereby.
    Type: Application
    Filed: August 1, 2005
    Publication date: November 24, 2005
    Inventors: Joachim Komoschinski, Herbert Diehl
  • Preparation of 4-amino-1-naphthol ethers
    Patent number: 6964963
    Abstract: The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl group is cleaved off, and further describes 4-acetamino-1-naphthol ethers obtained thereby.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: November 15, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Komoschinski, Herbert Diehl
  • Method for producing amines
    Publication number: 20050113582
    Abstract: The invention relates to a special two-step method for producing amines on the basis of amides by reacting them with halides or hypohalites in an aqueous solution in a Hofmann degradation reaction. The amide is reacted in an alkaline solution and/or suspension with halides or hypohalites and the reaction mixture obtained in step 1 is added to an aqueous alkaline solution having a temperature of at least 40° C.
    Type: Application
    Filed: December 17, 2002
    Publication date: May 26, 2005
    Inventors: Peter Wenzl, Friedrich Durrholz, Herbert Diehl
  • Method for producing 8-methoxy-quinolinecarboxylic acids
    Patent number: 6897315
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: May 24, 2005
    Assignee: Bayer HealthCare Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Diehl
  • Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
    Publication number: 20040044205
    Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed).
    Type: Application
    Filed: June 17, 2003
    Publication date: March 4, 2004
    Inventors: Herbert Diehl, Andreas Krebs, Elvira Krebs, Walter Lange, Hanns-Ingolf Paul, Dietrich Seidel, Rolf Grosser, Tobias Reichelt
  • Process for the preparation of specific aromatic aldehydes
    Publication number: 20030232989
    Abstract: A new process for the preparation of specific aromatic aldehydes by ozonolysis of aromatic alkenes is provided. This new process can be advantageously integrated into a synthesis of specific chiral diols using aromatic aldehydes of this type.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 18, 2003
    Inventors: Stefan Antons, Joachim Rehse, Herbert Diehl, Christian Laue
  • Preparation of 4-amino-1-naphthol ethers
    Publication number: 20030083525
    Abstract: The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl group is cleaved off, and further describes 4-acetamino-1-naphthol ethers obtained thereby.
    Type: Application
    Filed: August 27, 2002
    Publication date: May 1, 2003
    Inventors: Joachim Komoschinski, Herbert Diehl
  • Process for preparing piperidines
    Patent number: 6458954
    Abstract: Piperidines are prepared in an advantageous manner by catalytic hydrogenation of activated pyridines in the presence of palladium catalysts if the palladium catalyst is palladium-on-carbon and the solvents are aromatic hydrocarbons.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: October 1, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Guido Giffels, Herbert Diehl, Georg Martin, Lutz Frohn, Erich Hammerschmidt
  • Racemization of R,S-dioxo-benzylpyrrolopiperidine
    Patent number: 6392044
    Abstract: Cis-R-dioxo-benzylpyrrolopiperidine is racemized in a particularly advantageous manner by treating it with a substoichiometric amount of base, preferably at temperatures below about 40° C.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: May 21, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Diehl, Georg Martin, Wilfried Jaworek, Andreas Krebs, Joachim Westen
  • Process for preparing 3-hydroxybenzyl alcohol
    Patent number: 6380441
    Abstract: 3-Hydroxybenzyl alcohol can be prepared in a simple and inexpensive way by subjecting 3-chloromethylphenyl chloroformate to an acidolysis with a carboxylic acid or a carboxylic acid salt and subsequently subjecting the reaction product of the first step to an alcoholysis.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: April 30, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Franz-Josef Mais, Herbert Diehl
  • PROCESS FOR PREPARING 3-HYDROXYBENZYL ALCOHOL
    Publication number: 20020032353
    Abstract: 3-Hydroxybenzyl alcohol can be prepared in a simple and inexpensive way by subjecting 3-chloromethylphenyl chloroformate to an acidolysis with a carboxylic acid or a carboxylic acid salt and subsequently subjecting the reaction product of the first step to an alcoholysis.
    Type: Application
    Filed: September 7, 2001
    Publication date: March 14, 2002
    Inventors: Franz-Josef Mais, Herbert Diehl
  • Process for preparing piperidines
    Publication number: 20010056186
    Abstract: Piperidines are prepared in an advantageous manner by catalytic hydrogenation of activated pyridines in the presence of palladium catalysts if the palladium catalyst is palladium-on-carbon and the solvents are aromatic hydrocarbons.
    Type: Application
    Filed: April 30, 2001
    Publication date: December 27, 2001
    Inventors: Guido Giffels, Herbert Diehl, Georg Martin, Lutz Frohn, Erich Hammerschmidt
  • Process for preparing nifedipine
    Patent number: 6294673
    Abstract: The invention relates to a process for the preparation of nifedipine by the reaction of methyl 2-(2-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate and the use of the nifedipine thus prepared for the production of a medicament.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: September 25, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Mathias Berwe, Herbert Diehl, Karl Rittner, Karl-Heinz Wahl, Hans-Peter Wirges
  • One-pot process for the preparation of 3-quinolonecarboxylic acid derivatives
    Patent number: 5639886
    Abstract: The present invention relates to a one-pot process for the preparation of 7-heterocyclyl-substituted 3-quinolonecarboxylic acid derivatives. They possess a strong anti-microbial effect. They include active compounds such as, for example, ofloxacin, ciprofloxacin or enrofloxacin.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: June 17, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Zerbes, Paul Naab, Gerhard Franckowiak, Herbert Diehl