Patents by Inventor Herbert E. Paaren
Herbert E. Paaren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6448419Abstract: Disclosed is a method of preparing 2-hydroxy-3,17&bgr;-estradiol derivatives wherein 3,17&bgr;-estradiol is reacted with an organolithium reagent and reacted with either a boron reagent or a silicon reagent to form either a 2-boronyl or a 2-silyl modified estradiol analog represented by the corresponding structural formulae: R1 and R2 are each independently a hydroxyl protecting group. R3, R4 and R5 are selected from the group consisting of halogens, alkyl, aryl, hydroxy, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl.Type: GrantFiled: August 7, 2001Date of Patent: September 10, 2002Assignee: Tetrionics, Inc.Inventors: Herbert E. Paaren, Steven R. Duff
-
Patent number: 6080879Abstract: This invention provides a novel synthesis and crystallization method and solvent for producing hexafluoro-vitamin D compounds, including 26, 26, 26, 27, 27, 27-hexafluoro-1.alpha., 25-dihydroxyvitamin D.sub.3. Crystalline forms of such compounds are provided that are especially suited for pharmaceutical use. Such compounds can exhibit biological activity for treating cancers, osteoporosis and psoriasis.Type: GrantFiled: August 11, 1999Date of Patent: June 27, 2000Assignee: Tetrionics, Inc.Inventor: Herbert E. Paaren
-
Patent number: 5936105Abstract: 19-nor-vitamin D analog compounds and a method of synthesizing such compounds are disclosed. More particularly, examples of such compounds include 14-epi-19-nor-1.alpha.,25-dihydroxyvitamin D.sub.3, 14-epi-20-epi-19-nor-1.alpha., 25-dihydroxyvitamin D.sub.3, 14-epi-20-epi-19-nor-1.alpha.-hydroxyvitamin D.sub.3, 14-epi-19-nor-1.alpha., 25-dihydroxyvitamin D.sub.2, 14-epi-19-nor-24-homo-1.alpha., 25-didydroxyvitamin D.sub.3, 14-epi-19-nor-20(S)-hydroxymethyl-1.alpha.-hydropregnacalciferol, and 14-epi-19-nor-20(R)-hydroxymethyl-1.alpha.-hydroxypregnacalciferol.Type: GrantFiled: June 11, 1998Date of Patent: August 10, 1999Assignee: Tetrionics, Inc.Inventor: Herbert E. Paaren
-
Patent number: 4448726Abstract: This invention is directed to a new class of vitamin D compounds which are characterized by a modified ring A and triene structures and to a method for preparing same. The 7,8-dihydroxy-, 10.19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D.sub.3 are specifically disclosed.Type: GrantFiled: May 11, 1983Date of Patent: May 15, 1984Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Connie M. Smith
-
Patent number: 4338250Abstract: A process for preparing biologically active 1.alpha.-hydroxyvitamin D compounds from vitamin D compounds by hydroxylation at carbon 1 and subsequent photochemical isomerization, and novel intermediates and products resulting from this process are provided.Type: GrantFiled: April 27, 1981Date of Patent: July 6, 1982Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
-
Patent number: 4336193Abstract: The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D.sub.3 -26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recovery of the desired 25-hydroxyvitamin D.sub.3 -26,23-lactone.The invention also provides new intermediate compounds in their various isomeric forms derived during the process for preparing the said vitamin D.sub.3 lactones.25-Hydroxyvitamin D.sub.3 -26,23-lactone is recognized as having vitamin D-like activity and is believed to play an important role in the regulation of calcium and phosphate levels in the animal and human organism. The present invention provides a convenient method for preparing the various isomeric forms of this compound.Type: GrantFiled: January 26, 1981Date of Patent: June 22, 1982Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Joseph K. Wichmann, Mary A. Fivizzani
-
Patent number: 4313942Abstract: The invention provides a method for chemically activating vitamin D compounds to obtain active rodenticidal preparations.The activated vitamin D preparation offers an effective and relatively inexpensive rodenticidal material.Type: GrantFiled: October 9, 1979Date of Patent: February 2, 1982Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Helen Frank
-
Patent number: 4307231Abstract: The invention provides a new vitamin D compound, 1.alpha.,25-dihydroxy-vitamin D.sub.3 26,23-lactone.The compound is characterized by vitamin D-like activity.Type: GrantFiled: July 18, 1980Date of Patent: December 22, 1981Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Herbert E. Paaren, Joseph K. Wichmann
-
Patent number: 4297289Abstract: A method for isotopically labeling carbon-6 of vitamin D and 5,6-trans-vitamin D compounds which comprises reducing the corresponding 6-oxo-cyclovitamin with a tritio- or deutero-borohydride and subjecting the reduction product to acid-catalyzed solvolysis.The 6-labeled compounds find application in the elucidation of vitamin D metabolism and function and in vitamin metabolite analyses.Type: GrantFiled: July 17, 1980Date of Patent: October 27, 1981Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Mary A. Fivizzani
-
Patent number: 4265822Abstract: A method for preparing 1.alpha.-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds which comprises allylically oxidizing a 5,6-trans-vitamin D compound, subjecting the oxidation product to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated compound.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.Type: GrantFiled: September 10, 1979Date of Patent: May 5, 1981Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
-
Patent number: 4260549Abstract: An improved method for the preparation of 1.alpha.-hydroxylated vitamin D compounds involving directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof, wherein the 1.alpha.-hydroxycyclovitamin D intermediate is solvolyzed directly, without first converting the 1-hydroxy group to a 1-O-acyl function as a protective measure.Type: GrantFiled: May 21, 1979Date of Patent: April 7, 1981Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, David E. Hamer
-
Patent number: 4234495Abstract: A method for preparing 1.alpha.-hydroxyvitamin D compounds from 1.alpha.-hydroxy-3,5-cyclovitamin D compounds which comprises solvolyzing the 3,5-cyclovitamin D compound, exposing the solvolysis reaction products to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated vitamin D compounds.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.Type: GrantFiled: September 10, 1979Date of Patent: November 18, 1980Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
-
Patent number: 4202829Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors of derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.Type: GrantFiled: December 13, 1978Date of Patent: May 13, 1980Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
-
Patent number: 4195027Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.Type: GrantFiled: June 12, 1978Date of Patent: March 25, 1980Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren