Abstract: A surgical instrument stabilizes an implant as the implant is secured to native tissue at a damaged tissue site such as in an intra-articular space. The instrument has a proximal end portion, a distal end portion and an intermediate portion. The distal end portion has a template for guiding an attachment mechanism into the implant and the adjacent native tissue. The distal end portion can also have barbs to engage the implant to enhance stabilization of the implant. Several instruments can be provided in a surgical kit with different lengths and shapes of distal end portions. A surgical kit could also contain modular distal end portions of varying sizes and shapes. A surgical method utilizing the stabilizing instrument is also disclosed.

Abstract: Surgical instruments for use in minimally invasive surgery are described. The instruments have parts that are easily separable and easily assembled. A reciprocal slide member is operable by a cam portion of a lever received in a slot in the slide member. There is no mechanical connection between the lever and the slide member. The slide member is connected to elongate surgical implement components that extend through an elongate support member. The elongate surgical implement components are capable of reciprocal movement in the proximal-distal direction. In some embodiments, the elongate surgical implements can be used for measuring distances arthroscopically; these surgical implements can have beveled ends for more precise measurement of distances. The surgical instrument can be modular, with separate tool and actuator modules. The surgical instrument can be used with any implement that can be operated by reciprocal motion.

Abstract: Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus.

Abstract: An articular cartilage fixation device and method for repairing and regenerating diseased or injured soft tissue such as articular cartilage of the knee, hip, shoulder, and the like. A cartilage flap or cartilage repair device is retained within the chondral or osteochondral defect for a an sufficient amount of time such that the cartilage repair device can perform its function and facilitate an appropriate healing response. A plurality of biocompatible anchors are attached to a plurality of flexible members and are shaped to seat into the tissue beneath or near the defect such that the cartilage flap is retained within the defect.

Abstract: Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus.

Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.

Abstract: The present invention relates to medical devices for repairing tissue and more specifically to devices which facilitate tissue regeneration and to surgical methods for the implantation and fixation of such devices. In one embodiment, the medical device is an elongate conduit that includes a longitudinal bore extending therethrough to facilitate the transfer of blood from a vascular region of tissue to a tear or damaged area located in an avascular and/or semi-vascular region of tissue. A filament and/or filaments are attached to the conduit and are positioned to secure the conduit and fixate the adjacent tear walls in mutual engagement. In another embodiment, a series of conduits are connected via a filament and/or filaments to facilitate the implantation of multiple conduits.

Abstract: The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then used as fluids, gels or foams. By providing a product bag, the compositions can be delivered as gels or as sprays. By dissolving propellant gases in the compositions, the materials can be delivered as foams, which have decreased density, and therefore can adhere to surfaces that previously have been difficult to coat with antiadhesion gels. Delivery systems can also provide mechanisms for expelling more product, and for directing the flow of materials leaving the delivery system. Bioresorbable, bioadhesive, anti-adhesion, and/or hemostatic compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions.

Abstract: A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.

Abstract: An apparatus for use in affixing material to a location under repair includes a material retention member and an anchor. The anchor is configured to be inserted into a cavity in bone tissue, the anchor having a first end and a second end. The anchor also includes one or more raised ribs. The material retention member extends radially from the first end of the anchor in a plurality of directions, the material retention member including at least one contact surface adapted to exert a retention force on material that is interposed between the material retention device and the bone tissue.

Abstract: Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus.

Abstract: A device for locking a suture in place without the need for tying knots once the suture is placed within tissue is provided. The device comprises an anchor having a cannula and a locking mechanism for securing the suture within the cannula.

Abstract: The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions.

Abstract: A slide instrument has a longitudinal slide portion and spaced walls defining longitudinal channels. The slide instrument may be sized so that it can be inserted through standard arthroscopic portals to position the distal end of the slide instrument at a damaged tissue site. The slide instrument may be used to deliver an implant to the damaged tissue site. The implant has edges that fit within the longitudinal channels so that the implant can be moved along the slide portion to the distal end of the slide to deliver the implant to the damaged tissue site. The shape of the slide instrument protects the implant from damage as the implant is delivered from outside the patient's body to the damaged tissue site.

Abstract: A surgical instrument has a main shaft underlying a slide member. The slide member is movable in a proximal-distal direction. The distal end of the slide member has an open position and a closed position. The closed position is spaced from the open position in the proximal-distal direction. There is a gap between the distal end of the slide member and the distal end of the main shaft when the instrument is in the open position. The gap is smaller when the instrument is in the closed position. An implant can be received in the gap and delivered to a damaged tissue site using the instrument. An implant protector can be used when delivering the implant with the instrument. A pivotable implant cover can be used to protect the implant instead of the slide member.

Abstract: Surgical instruments for use in minimally invasive surgery are described. The instruments have parts that are easily separable and easily assembled. A reciprocal slide member is operable by a cam portion of a lever received in a slot in the slide member. There is no mechanical connection between the lever and the slide member. The slide member is connected to elongate surgical implement components that extend through an elongate support member. The elongate surgical implement components are capable of reciprocal movement in the proximal-distal direction. In some embodiments, the elongate surgical implements can be used for measuring distances arthroscopically; these surgical implements can have beveled ends for more precise measurement of distances. The surgical instrument can be modular, with separate tool and actuator modules. The surgical instrument can be used with any implement that can be operated by reciprocal motion.

Abstract: A surgical instrument has an elongate guide member and a reciprocable member. The elongate guide member provides a protected path of travel for an implant from outside the body to a position near a damaged tissue site. The reciprocable member is movable along the elongate guide member to push the implant along its path of travel. The reciprocable member can include an implant carrier. The implant can be an orthopaedic implant for repair or regeneration of soft tissue at a damaged joint site. The implant can be larger than the transverse dimension of the elongate guide member and folded or rolled to fit within the elongate guide member. Use of this instrument protects the implant from damage as it is delivered to the damaged joint site. The invention also includes a surgical method for delivering an implant to a damaged tissue site.

Abstract: A surgical instrument stabilizes an implant as the implant is secured to native tissue at a damaged tissue site such as in an intra-articular space. The instrument has a proximal end portion, a distal end portion and an intermediate portion. The distal end portion has a template for guiding an attachment mechanism into the implant and the adjacent native tissue. The distal end portion can also have barbs to engage the implant to enhance stabilization of the implant. Several instruments can be provided in a surgical kit with different lengths and shapes of distal end portions. A surgical kit could also contain modular distal end portions of varying sizes and shapes. A surgical method utilizing the stabilizing instrument is also disclosed.

Abstract: A device for repairing a defect in a soft tissue is disclosed, the device including a first anchor engaging a first surface of the soft tissue on a first side of the defect, the first anchor having a locking mechanism, a second anchor for engaging against a second side of the soft tissue on a second side of the defect, and a suture adjustably connecting the second anchor to the first anchor.

Abstract: An implantable tissue repair device has a cover and tissue regeneration material. The cover includes a top panel and a bottom panel joined together along a leading edge. The tissue regeneration material is positioned between the top and bottom panels. The cover includes a continuous sheet of biocompatible material extending across the edge and into the top panel and bottom panel. The cover is thicker along the leading edge than at least a portion of the top panel and thicker than at least a portion of the bottom panel. At least a portion of one of the panels covering the tissue regeneration material is thicker than a portion of the other panel covering the tissue regeneration material. A method of making the device is also disclosed.