Patents by Inventor Herbert F. Cattell
Herbert F. Cattell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8577621Abstract: A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.Type: GrantFiled: November 4, 2011Date of Patent: November 5, 2013Assignee: Agilent Technologies, Inc.Inventors: Charles David Troup, Herbert F. Cattell
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Publication number: 20120053086Abstract: A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.Type: ApplicationFiled: November 4, 2011Publication date: March 1, 2012Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Charles D. Troup, Herbert F. Cattell
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Patent number: 8073626Abstract: A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.Type: GrantFiled: January 31, 2003Date of Patent: December 6, 2011Assignee: Agilent Technologies, Inc.Inventors: Charles D. Troup, Herbert F. Cattell
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Patent number: 7412085Abstract: Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.Type: GrantFiled: March 13, 2006Date of Patent: August 12, 2008Assignee: Agilent Technologies, Inc.Inventors: Herbert F. Cattell, Andreas N. Dorsel, John W. Sadler, Nicholas M. Sampas
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Patent number: 7221785Abstract: A method and system for estimating the background signal over an arbitrarily-sized region of a scanned image of a molecular array, including a background region surrounding the ROI corresponding to the feature. A bit mask is generated, based on a molecular-array, feature-based data set that includes pixel-based intensities and a list of features, including feature coordinates and feature ROI radii, to indicate those pixels in the scanned image of the molecular array corresponding to background, and those pixels in the scanned image of the molecular array corresponding to features and ROIs. An integrated intensity for a background region of arbitrary size and shape can be efficiently determined by selecting pixels within the background region that are indicated to be background pixels in the bit mask.Type: GrantFiled: May 21, 2002Date of Patent: May 22, 2007Assignee: Agilent Technologies, Inc.Inventors: Bo U. Curry, Herbert F. Cattell, Srinka Ghosh
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Patent number: 7027930Abstract: Methods of using an addressable array of biopolymers which has been exposed to a sample, and apparatus and computer program products for use of the arrays. In one embodiment the method includes detecting signals from the exposed array to obtain a signal image of the array. The array signal image is saved in a memory. Based on the detected signals, a shape of each region in one or more sets of multiple regions on the array signal image is established. A definition of the shapes of the established regions of each set is saved in a memory. Each region of each set is processed according to a corresponding routine for that set.Type: GrantFiled: January 31, 2001Date of Patent: April 11, 2006Assignee: Agilent Technologies, Inc.Inventor: Herbert F. Cattell
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Patent number: 7027629Abstract: Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.Type: GrantFiled: September 9, 2002Date of Patent: April 11, 2006Assignee: Agilent Technologies, Inc.Inventors: Herbert F. Cattell, Andreas N. Dorsel, John W. Sadler, Nicholas M. Sampas
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Patent number: 7006927Abstract: A method and system for extracting data signals from a scanned image resulting from optical, radiometric, or other types of analysis of a molecular array. The positions of corner features are first located. Then, an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated based on the positions of strong features, and is used to identify the positions of weak features and the positions of the local background regions surrounding all features. Finally, signal intensity values are extracted from the features and their respective local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.Type: GrantFiled: February 28, 2002Date of Patent: February 28, 2006Assignee: Agilent Technologies, Inc.Inventors: Zohar Yakhini, Cynthia Y. Enderwick, Glenda C. Delenstarr, Paul K. Wolber, Nicholas M. Sampas, Herbert F. Cattell, Scott D. Connell
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Patent number: 6993172Abstract: A method and system for employing pixel-based, signal-intensity data contained within areas of a scanned image of a molecular array corresponding to features and feature backgrounds in order to determine whether or not the features or feature backgrounds have non-uniform signal intensities and are thus outlier features and outlier feature backgrounds. A calculated, estimated variance for the signal intensities within a feature or feature background is compared to a maximum allowable variance calculated for the feature or feature background based on a signal intensity variance model. When the experimental variance is less than or equal to the maximum allowable variance, the feature or feature background is considered to have acceptable signal-intensity uniformity. Otherwise, the feature or feature background is flagged as an outlier feature or outlier feature background.Type: GrantFiled: June 29, 2001Date of Patent: January 31, 2006Assignee: Agilent Technologies, Inc.Inventors: Scott D. Connell, Herbert F. Cattell, Glenda C. Delenstarr, Nicholas M Sampas, Andreas N. Dorsel
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Patent number: 6913200Abstract: Methods for programming an array scanner to scan a plurality of biopolymer arrays are provided. In the subject methods, individual scanning parameters for at least two different arrays of the plurality of arrays to be scanned are selected and input into the array scanner prior to scanning the plurality arrays. The programmed scanner then scans the plurality of arrays according to the pre-selected scanning parametersAlso provided are scanners programmed according to the subject methods, as well as computer programming that provides for programming of scanners according to the subject methods. The subject methods and compositions find use in a variety of different applications, including both genomics and proteomics applications.Type: GrantFiled: November 20, 2002Date of Patent: July 5, 2005Assignee: Agilent Technologies, Inc.Inventors: Debra Ann Sillman, Xiangyang Zhou, Chetan D Jadhaw, Herbert F. Cattell, Jayati Ghosh
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Patent number: 6879915Abstract: A method of using an addressable array of biopolymers on a substrate includes receiving the addressable array and an associated machine readable identifier carried on an array substrate or array housing. The array is exposed to a sample and read, and the identifier machine read as an identifier signal. Biological function data for one or more of the biopolymers is retrieved from a memory based on the identifier signal. Other methods in which first and updated sets of feature characteristic data may readily be provided to array users, and methods of generating arrays are also provided, as are apparatus and computer program products which can execute a method for generating or using arrays.Type: GrantFiled: January 31, 2001Date of Patent: April 12, 2005Assignee: Agilent Technologies, Inc.Inventor: Herbert F. Cattell
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Publication number: 20040203047Abstract: A method and apparatus for fabricating an array of polynucleotides on a substrate. A polynucleotide deposition system is operated to deposit an array of polynucleotide containing fluid droplets on the substrate and which, when dry, will yield polynucleotide containing spots of respective target locations and dimensions. Droplets deposited by the system are allowed to dry to yield actual spots. An image is captured of the substrate with dried actual spots. Dried actual spot locations or dimensions from the image, are compared with target locations or dimensions of polynucleotide containing spots. A signal indicative of the result of the comparison may be generated.Type: ApplicationFiled: April 27, 2004Publication date: October 14, 2004Inventors: Michael P. Caren, Herbert F. Cattell, Richard P. Tella, Peter G. Webb, Jay K. Bass
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Publication number: 20040203138Abstract: A method and apparatus for fabricating an array of polynucleotides on a substrate. A polynucleotide deposition system is operated to deposit an array of polynucleotide containing fluid droplets on the substrate and which, when dry, will yield polynucleotide containing spots of respective target locations and dimensions. Droplets deposited by the system are allowed to dry to yield actual spots. An image is captured of the substrate with dried actual spots. Dried actual spot locations or dimensions from the image, are compared with target locations or dimensions of polynucleotide containing spots. A signal indicative of the result of the comparison may be generated.Type: ApplicationFiled: April 27, 2004Publication date: October 14, 2004Inventors: Michael P. Caren, Herbert F. Cattell, Richard P. Tella, Peter G. Webb, Jay K. Bass
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Publication number: 20040197817Abstract: A method and apparatus for fabricating an array of polynucleotides on a substrate. A polynucleotide deposition system is operated to deposit an array of polynucleotide containing fluid droplets on the substrate and which, when dry, will yield polynucleotide containing spots of respective target locations and dimensions. Droplets deposited by the system are allowed to dry to yield actual spots. An image is captured of the substrate with dried actual spots. Dried actual spot locations or dimensions from the image, are compared with target locations or dimensions of polynucleotide containing spots. A signal indicative of the result of the comparison may be generated.Type: ApplicationFiled: April 27, 2004Publication date: October 7, 2004Inventors: Michael P. Caren, Herbert F. Cattell, Richard P. Tella, Peter G. Webb, Jay K. Bass
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Publication number: 20040152082Abstract: A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.Type: ApplicationFiled: January 31, 2003Publication date: August 5, 2004Inventors: Charles D. Troup, Herbert F. Cattell
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Publication number: 20040094626Abstract: Methods for programming an array scanner to scan a plurality of biopolymer arrays are provided. In the subject methods, individual scanning parameters for at least two different arrays of the plurality of arrays to be scanned are selected and input into the array scanner prior to scanning the plurality arrays. The programmed scanner then scans the plurality of arrays according to the pre-selected scanning parametersAlso provided are scanners programmed according to the subject methods, as well as computer programming that provides for programming of scanners according to the subject methods. The subject methods and compositions find use in a variety of different applications, including both genomics and proteomics applications.Type: ApplicationFiled: November 20, 2002Publication date: May 20, 2004Inventors: Debra A. Sillman, Xiangyang Zhou, Chetan D. Jadhaw, Herbert F. Cattell, Jayati Ghosh
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Publication number: 20030219151Abstract: A method and system for estimating the background signal over an arbitrarily-sized region of a scanned image of a molecular array, including a background region surrounding the ROI corresponding to the feature. A bit mask is generated, based on a molecular-array, feature-based data set that includes pixel-based intensities and a list of features, including feature coordinates and feature ROI radii, to indicate those pixels in the scanned image of the molecular array corresponding to background, and those pixels in the scanned image of the molecular array corresponding to features and ROIs. An integrated intensity for a background region of arbitrary size and shape can be efficiently determined by selecting pixels within the background region that are indicated to be background pixels in the bit mask.Type: ApplicationFiled: May 21, 2002Publication date: November 27, 2003Inventors: Bo U. Curry, Herbert F. Cattell, Srinka Ghosh
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Publication number: 20030156136Abstract: A method and system for visual display of feature extraction results to a user of a molecular array feature extraction software package. The feature extraction results are displayed as visual marks superimposed on an image of a molecular array, and numerical and textual feature extraction results for, and other information about, a particular feature may be displayed to a user when the user positions a mouse cursor over the feature in the displayed image. A user may direct display of visual mark for only statistically invalid features and feature backgrounds.Type: ApplicationFiled: February 15, 2002Publication date: August 21, 2003Inventors: Herbert F. Cattell, Nicholas M. Sampas
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Publication number: 20030143551Abstract: A method, apparatus and computer program products relating to the reading of chemical arrays and extracting feature characteristics therefrom. In a method multiple chemical arrays each having a plurality of features, are read to obtain array signal data. The array signal data for the multiple arrays is saved in a memory. The saved signal data for chemical arrays is retrieved from the memory and feature characteristics extracted therefrom, wherein the saved signal data for a chemical array is extracted while another chemical array is being read.Type: ApplicationFiled: January 30, 2002Publication date: July 31, 2003Inventor: Herbert F. Cattell
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Publication number: 20030081819Abstract: A method and system for employing pixel-based, signal-intensity data contained within areas of a scanned image of a molecular array corresponding to features and feature backgrounds in order to determine whether or not the features or feature backgrounds have non-uniform signal intensities and are thus outlier features and outlier feature backgrounds. A calculated, estimated variance for the signal intensities within a feature or feature background is compared to a maximum allowable variance calculated for the feature or feature background based on a signal intensity variance model. When the experimental variance is less than or equal to the maximum allowable variance, the feature or feature background is considered to have acceptable signal-intensity uniformity. Otherwise, the feature or feature background is flagged as an outlier feature or outlier feature background.Type: ApplicationFiled: June 29, 2001Publication date: May 1, 2003Inventors: Scott D. Connell, Herbert F. Cattell, Glenda C. Delenstarr, Nicholas M. Sampas, Andreas N. Dorsel