Patents by Inventor Herbert G. Johnson
Herbert G. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4737519Abstract: The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.Type: GrantFiled: June 25, 1986Date of Patent: April 12, 1988Assignee: The Upjohn CompanyInventors: Ayako Yamashita, Herbert G. Johnson
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Patent number: 4262123Abstract: Compounds of the formula below are useful for expanding the lumina of air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano;R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl,CH.sub.2 Z wherein Z is fluoro, chloro, or bromo,CO.sub.2 M, CH.sub.2 CO.sub.2 M, CH.sub.2 CH.sub.2 CO.sub.2 M and CHR.sub.3 CO.sub.2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R.sub.2 is CH.sub.2 CO.sub.2 M or CHR.sub.3 CO.sub.2 M.Type: GrantFiled: May 31, 1979Date of Patent: April 14, 1981Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson
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Patent number: 4242342Abstract: Compounds of the formula below are useful for expanding the lumina of air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano;R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl,CH.sub.2 Z wherein Z is fluoro, chloro, or bromo,CO.sub.2 M, CH.sub.2 CO.sub.2 M, CH.sub.2 CH.sub.2 CO.sub.2 M and CHR.sub.3 CO.sub.2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R.sub.3 is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R.sub.2 is CH.sub.2 CO.sub.2 M or CHR.sub.3 CO.sub.2 M.Type: GrantFiled: May 31, 1979Date of Patent: December 30, 1980Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson
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Patent number: 4181724Abstract: Compounds of the formula below are useful for expanding the lumina or air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano;R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl,CH.sub.2 Z wherein Z is fluoro, chloro, or bromo,CO.sub.2 M, CH.sub.2 CO.sub.2 M, CH.sub.2 CH.sub.2 CO.sub.2 M and CHR.sub.3 CO.sub.2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R.sub.3 is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R.sub.2 is CH.sub.2 CO.sub.2 M or a CHR.sub.3 CO.sub.2 M.Type: GrantFiled: September 11, 1978Date of Patent: January 1, 1980Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson
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Patent number: 4126617Abstract: Novel chemical compounds of the formula: ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, phenyl, alkali metal, or an amine cation;X and Y can be the same or different and are selected from the group consisting of hydrogen, alkyl or from one to six carbon atoms, inclusive, cycloalkyl of 5 or 6 carbon atoms, inclusive, phenyl, hydroxyl, alkoxy having from one to three carbon atoms, inclusive, halogen, trifluoromethyl, cyano, carboxyamide and ##STR2## where Q is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, alkali metal, and an amine cation, with the proviso that whereR is hydrogen, alkali metal or an amine cation, then Q is the same as R, and whereR is phenyl or alkyl from one to three carbon atoms, then Q is phenyl or alkyl from one to three carbon atoms; andZ is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and phenyl.Type: GrantFiled: August 5, 1976Date of Patent: November 21, 1978Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson, John B. Wright
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Patent number: 4104060Abstract: This application discloses method and apparatus for solid-phase conversion of particulate metal (or swarf) into continuous metal-jacketed strip by feeding particulate metal, together with any desired reducing or alloying additives, between travelling metal jacket sheet components, the lower channel-shaped and the upper flat strip closely fitting between the channel sides; injecting air-purging reducing or inert gas to create an inside environment of protective gas rather higher than atmospheric air pressure, the gas entering the material and the embrassing jacket sheet components which after filling and closing form a permanent circumferentially and longitudinally complete jacket around the material; compacting the material in the jacket sheet components after closing by repeated compacting actions; feeding this strip forward between successive compacting actions while clear of the compacting die elements; sealing the jacket components closed together over the compacted material to form a circumferentially coType: GrantFiled: November 23, 1976Date of Patent: August 1, 1978Inventor: Herbert G. Johnson
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Patent number: 4064248Abstract: An improved dosage regimen for the administration of the pharmacologically acceptable salts or esters of a compound of the formula: ##STR1## wherein X and Y can be the same or different and are selected from the group consisting of hydrogen, alkyl of from one to six carbon atoms, inclusive, cycloalkyl of five or six carbon atoms, inclusive, phenyl, hydroxyl, alkoxy having from one to three carbon atoms, inclusive, halogen, trifluoromethyl, cyano, carboxyamide and --CO.sub.2 H; Z is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and phenyl and provided when X is chloro at least one of Y and Z are other than hydrogen consisting of the initial administration of a priming dose (high) and thereafter administering a maintenance (low) dose of from 1/5th to 1/1000th of the priming dose, the maintenance doses being continually administered every 4 to 12 hours or as needed.Type: GrantFiled: February 4, 1974Date of Patent: December 20, 1977Assignee: The Upjohn CompanyInventor: Herbert G. Johnson
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Patent number: 4046910Abstract: A dosing schedule for Disodiumcromoglycate and Disodiumcromoglycate biologues whereby a substantially smaller dosage is required to bring about effective allergy inhibition. Compositions are also provided.Type: GrantFiled: April 14, 1976Date of Patent: September 6, 1977Assignee: The Upjohn CompanyInventor: Herbert G. Johnson
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Patent number: 4038398Abstract: Novel compounds of (I) ##STR1## are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.Type: GrantFiled: March 26, 1976Date of Patent: July 26, 1977Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson
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Patent number: 3963660Abstract: Novel compounds of formula 1 ##SPC1##And ##SPC2##Are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.Type: GrantFiled: March 31, 1975Date of Patent: June 15, 1976Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson
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Patent number: 3959289Abstract: Novel chemical compounds of the formula: ##SPC1##WhereinR is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, phenyl, alkali metal, or an amine cation;X and Y can be the same or different and are selected from the group consisting of hydrogen, alkyl of from one to six carbon atoms, inclusive, cycloalkyl of 5 or 6 carbon atoms, inclusive, phenyl, hydroxyl, alkoxy having from one to three carbon atoms, inclusive, halogen, trifluoromethyl, cyano, carboxyamide and O C-OQ, ##EQU1## where Q is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, alkali metal, and an amine cation, with the proviso that whereR is hydrogen, alkali metal or an amine cation, then Q is the same as R, and whereR is phenyl or alkyl from one to three carbon atoms, then Q is phenyl or alkyl from one to three carbon atoms; andZ is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and phenyl.Type: GrantFiled: December 11, 1974Date of Patent: May 25, 1976Assignee: The Upjohn CompanyInventors: Charles M. Hall, Herbert G. Johnson, John B. Wright