Patents by Inventor Herbert H. Hill
Herbert H. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11726102Abstract: Disclosed herein are embodiments of methods for detecting the presence of and amount of drugs in a sample, particularly a particle sample obtained from a subject. In particular disclosed embodiments, the particle samples are skin particle samples, saliva particle samples, and/or mucous samples isolated from a subject and analyzed using thermal desorption methods combined with a selected detection method.Type: GrantFiled: December 20, 2018Date of Patent: August 15, 2023Assignee: Washington State UniversityInventors: Herbert H. Hill, Jr., Brian Clowers, Nicholas Lovrich
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Patent number: 10585066Abstract: Ion mobility spectrometry (IMS) systems, devices, and associated methods of operation are disclosed herein. In one embodiment, an IMS system includes an ionization region configured to receive and ionize a sample into ionized molecules and a detector configured to detect ionized molecules. The IMS system also includes a drift region in between and directly coupled to both the ionization region and the detector. The drift tube includes a first ion gate proximate the ionization region and a second ion gate proximate the detector. The first and second ion gates are configured to alternately introduce a batch of ionized molecules toward the detector while the other is maintained open, thereby allowing accurate measurement of a drift time of the ionized molecules corresponding to a drift length that is a distance between the first and second ion gates.Type: GrantFiled: June 11, 2018Date of Patent: March 10, 2020Assignee: Washington State UniversityInventors: Brian Hauck, William Siems, Vincent McHugh, Charles S. Harden, Herbert H. Hill, Jr.
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Publication number: 20190195899Abstract: Disclosed herein are embodiments of methods for detecting the presence of and amount of drugs in a sample, particularly a particle sample obtained from a subject. In particular disclosed embodiments, the particle samples are skin particle samples, saliva particle samples, and/or mucous samples isolated from a subject and analyzed using thermal desorption methods combined with a selected detection method.Type: ApplicationFiled: December 20, 2018Publication date: June 27, 2019Inventors: Herbert H. Hill, Jr., Brian Clowers, Nicholas Lovrich
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Patent number: 10175196Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments for identifying material. An embodiment includes ionizing, in gas phase, a target substance; creating, in gas phase, a pulse of ionized material from the ionized target substance; injecting the pulse of ionized material into a condensed phase drift medium; and identifying, by at least one processor, the target substance using the pulse of ionized material in the condensed phase drift medium.Type: GrantFiled: June 11, 2014Date of Patent: January 8, 2019Assignee: The MITRE CorporationInventors: Samar Kumar Guharay, Herbert H. Hill, Jr.
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Publication number: 20180372683Abstract: Ion mobility spectrometry (IMS) systems, devices, and associated methods of operation are disclosed herein. In one embodiment, an IMS system includes an ionization region configured to receive and ionize a sample into ionized molecules and a detector configured to detect ionized molecules. The IMS system also includes a drift region in between and directly coupled to both the ionization region and the detector. The drift tube includes a first ion gate proximate the ionization region and a second ion gate proximate the detector. The first and second ion gates are configured to alternately introduce a batch of ionized molecules toward the detector while the other is maintained open, thereby allowing accurate measurement of a drift time of the ionized molecules corresponding to a drift length that is a distance between the first and second ion gates.Type: ApplicationFiled: June 11, 2018Publication date: December 27, 2018Inventors: Brian Hauck, William Siems, Vincent McHugh, Charles S. Harden, Herbert H. Hill, JR.
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Patent number: 10126265Abstract: The methods herein provide for analysis of ion populations. Certain aspects include: directing a continuous gas phase ion beam into an entrance of a drift tube configured within an ion mobility spectrometer; perturbing the flow of the continuous gas phase ion beam within a perturbation time range so as to cause one or more configured perturbations; configuring the drift tube to allow the one or more perturbations to separate due to the differences in mobilities; receiving the plurality of ions and the one or more perturbations at the entrance of a mass spectrometer; recording raw data indicative of the plurality of ions; and reconstructing the raw data to obtain one or more mass to charge and one or more ion mobility spectrum of the plurality of ions.Type: GrantFiled: March 2, 2017Date of Patent: November 13, 2018Assignee: WASHINGTON STATE UNIVERSITYInventors: Wenjie Liu, Herbert H. Hill, Jr., William F. Siems
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Publication number: 20170254778Abstract: The methods herein provide for analysis of ion populations. Certain aspects include: directing a continuous gas phase ion beam into an entrance of a drift tube configured within an ion mobility spectrometer; perturbing the flow of the continuous gas phase ion beam within a perturbation time range so as to cause one or more configured perturbations; configuring the drift tube to allow the one or more perturbations to separate due to the differences in mobilities; receiving the plurality of ions and the one or more perturbations at the entrance of a mass spectrometer; recording raw data indicative of the plurality of ions; and reconstructing the raw data to obtain one or more mass to charge and one or more ion mobility spectrum of the plurality of ions.Type: ApplicationFiled: March 2, 2017Publication date: September 7, 2017Inventors: Wenjie Liu, Herbert H. Hill, JR., William F. Siems
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Publication number: 20170023453Abstract: Disclosed herein are embodiments of methods for detecting the presence of and amount of drugs in a sample, particularly a particle sample obtained from a subject. In particular disclosed embodiments, the particle samples are skin particle samples, saliva particle samples, and/or mucous samples isolated from a subject and analyzed using thermal desorption methods combined with a selected detection method.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Applicant: Washington State UniversityInventors: Herbert H. Hill, JR., Brian Clowers, Nicholas Lovrich
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Publication number: 20160202211Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments for identifying material. An embodiment includes ionizing, in gas phase, a target substance; creating, in gas phase, a pulse of ionized material from the ionized target substance; injecting the pulse of ionized material into a condensed phase drift medium; and identifying, by at least one processor, the target substance using the pulse of ionized material in the condensed phase drift medium.Type: ApplicationFiled: June 11, 2014Publication date: July 14, 2016Applicants: The MITRE Corporation, Washington State UniversityInventors: Samar Kumar GUHARAY, Herbert H. HILL
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Patent number: 8812250Abstract: Ion mobility spectrometry systems, devices, and associated methods of operation are disclosed herein. In one embodiment, a method for performing ion mobility spectrometry includes ionizing a sample in gas phase and applying an electric field to the ionized sample in the gas phase, thereby moving the ionized sample along a drift region. The applied electric field has a plurality of strength values with respect to time, and the individual strength values being generally constant during a corresponding period of time. The method further includes detecting an ion intensity and a drift time of the ionized sample moving through the drift region under the applied electric field with the plurality of strength values.Type: GrantFiled: June 17, 2011Date of Patent: August 19, 2014Assignee: Washington State UniversityInventors: Herbert H. Hill, Eric J. Davis
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Patent number: 8716653Abstract: Various embodiments of ion detection systems, devices, and associated methods of operation are described herein. In one embodiment, a method for ion detection includes separating a target species from other species in an ionized sample of a first polarity, generating ions of a second polarity opposite the first polarity, and contacting ions of the second polarity with the ionized sample to generate emissions after separating the target species from other species in the ionized sample. The method also includes detecting the generated emissions when combining the ionized sampled of the first polarity with the ions of the second polarity.Type: GrantFiled: March 26, 2013Date of Patent: May 6, 2014Assignee: Washington State UniversityInventors: Herbert H Hill, Jr., Eric J. Davis, William F. Siems
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Publication number: 20130256525Abstract: Various embodiments of ion detection systems, devices, and associated methods of operation are described herein. In one embodiment, a method for ion detection includes separating a target species from other species in an ionized sample of a first polarity, generating ions of a second polarity opposite the first polarity, and contacting ions of the second polarity with the ionized sample to generate emissions after separating the target species from other species in the ionized sample. The method also includes detecting the generated emissions when combining the ionized sampled of the first polarity with the ions of the second polarity.Type: ApplicationFiled: March 26, 2013Publication date: October 3, 2013Inventors: Herbert H. Hill, JR., Eric J. Davis, William F. Siems
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Publication number: 20120004862Abstract: Ion mobility spectrometry systems, devices, and associated methods of operation are disclosed herein. In one embodiment, a method for performing ion mobility spectrometry includes ionizing a sample in gas phase and applying an electric field to the ionized sample in the gas phase, thereby moving the ionized sample along a drift region. The applied electric field has a plurality of strength values with respect to time, and the individual strength values being generally constant during a corresponding period of time. The method further includes detecting an ion intensity and a drift time of the ionized sample moving through the drift region under the applied electric field with the plurality of strength values.Type: ApplicationFiled: June 17, 2011Publication date: January 5, 2012Applicant: WASHINGTON STATE UNIVERSITYInventors: Herbert H. Hill, JR., Eric J. Davis
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Patent number: 7560688Abstract: Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.Type: GrantFiled: October 16, 2006Date of Patent: July 14, 2009Assignee: Washington State UniversityInventors: Brian H. Clowers, Herbert H. Hill, Jr., Prabha Dwivedi, Matthew Pollard
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Patent number: PP15924Abstract: A new and distinct cultivar of Guzmania plant named ‘Holiday’, characterized by its compact, upright and outwardly arching plant habit; green-colored foliage with purple-colored striations towards the base; inflorescences held upright and above foliage on strong scapes; inflorescences with closely-spaced dark purple-colored flower bracts that are tipped with white; and long-lasting inflorescences that maintain good coloration for about two to three months.Type: GrantFiled: September 30, 2004Date of Patent: August 16, 2005Assignee: Twyford International, Inc.Inventor: Herbert H. Hill, Jr.
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Patent number: PP12081Abstract: A Guzmania plant named ‘Symfonie Encore’ characterized by having variegated foliage that is reddish-pink at the sheath becoming cream-white at the apex of the leaf, large and long-lasting inflorescence with a distinctive yellow and red contrast, plants that are resistant to extremes in temperature (38-95° F.) and light intensity thereby tolerating a wide range of cultural conditions.Type: GrantFiled: November 2, 1999Date of Patent: September 11, 2001Inventor: Herbert H. Hill, Jr.
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Patent number: PP12176Abstract: A new Guzmania plant named ‘Anton’ particularly distinguished by its tall, purple bracted inflorescence. Plants of ‘Anton’ are of small to intermediate stature and are best grown in 10-cm to 12.5-cm pots. Plants of ‘Anton’ grow vigorously and produce exceptionally uniform crops. It tolerates a wide range of cultural conditions and is easy to grow.Type: GrantFiled: June 5, 2000Date of Patent: October 30, 2001Assignee: Twyford Plant Laboratories, Inc.Inventor: Herbert H. Hill, Jr.
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Patent number: PP13654Abstract: A new and distinct cultivar of Guzmania plant named ‘Esquire’, characterized by it upright and outwardly arching plant habit; small stature; dark green-colored foliage that is flushed or streaked with purple; inflorescences held upright and above foliage on strong scapes; inflorescences with closely-spaced bright red-colored flower bracts and tipped with white; and long-lasting inflorescences that maintain good coloration for about two to three months in an interior environment.Type: GrantFiled: May 31, 2002Date of Patent: March 11, 2003Assignee: Twyford International Inc.Inventor: Herbert H. Hill, Jr.
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Patent number: PP13679Abstract: A new and distinct cultivar of Guzmania plant named ‘Viola’, characterized by its upright and outwardly arching plant habit; medium green-colored foliage; inflorescences held upright and above foliage on strong scapes; branched inflorescences with showy red purple flower bracts; and long-lasting inflorescences that maintain good coloration for about two to three months.Type: GrantFiled: May 10, 2002Date of Patent: March 25, 2003Assignee: Twyford International Inc.Inventor: Herbert H. Hill, Jr.
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Patent number: PP10787Abstract: A new cultivar of Guzmania named `Olympic` having a very long lasting yellow and red bracted inflorescence. The inflorescence is clean appearing, and does not appear "flowered out" with age. The foliage is very dark green, shiny, durable and resistant to leaf spotting and tip browning. Plants of `Olympic` tolerate a wide range of cultural conditions and are easy to grow.Type: GrantFiled: June 18, 1997Date of Patent: February 9, 1999Assignee: Twyford International, Inc.Inventor: Herbert H. Hill, Jr.