Patents by Inventor Herbert Hugl

Herbert Hugl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6235925
    Abstract: Using the process according to the invention, it is possible to provide, with few reaction steps, a novel route to &agr;-substituted ring systems which optionally have further substituents.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: May 22, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christoph Gürtler, Manfred Jautelat, Helmut Greiving, Herbert Hugl
  • Patent number: 5942593
    Abstract: A process for the preparation of a polyurethane-urea elastomer having a mole ratio of NCO groups to all active hydrogen atoms in the range of 0.9 to 1.2 is disclosed. The process comprise reacting (A), (B) and (C.2) for form an NCO-containing prepolymer and then reacting said prepolymer with (C.1) and (D). Accordingly (A) is 5-isocyanato-1-(isocyanatomethyl)-1,1,3-trimethylcyclohexane or bis-(4-isocyanatocyclohexyl)-methane,(B) is polytetrahydrofuran or hexanediol polycarbonate and (C.2) is a chain extender. (C.1) is 5-amino-3-amino-methyl-1,3,3-trimethylcyclohexane or bis-(4-aminocyclohexyl)-methane and (D) is a molecular weight regulator. The elastomer thus produced is particularly suitable for the preparation of moldings, films, flexible tubing (for medical purposes) and catheters.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: August 24, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Pudleiner, Rolf Dhein, Herbert Hugl, Hanns-Peter Muller, Herbert Heidingsfeld, Hans-Georg Hoppe
  • Patent number: 5430121
    Abstract: The invention relates to thermoplastic polyurethanes modified with segmented siloxane block copolymers which are based on relatively high molecular weight dihydroxy compounds, diisocyanates, and difunctional chain extenders. The application also relates to their use in the medical field, and particularly as a catheter material.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: July 4, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Pudleiner, Herbert Hugl, Rolf Dhein, Hanns-Peter Muller
  • Patent number: 5391641
    Abstract: The invention relates to segmented N-alkyl polyurethane amides having an average molecular weight of 5,000 to 250,000, to a process for their production and to their use for the production of materials which may be used in the medical field.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: February 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Hugl, Burkhard Kohler, Rolf Dhein
  • Patent number: 5374704
    Abstract: The present invention is directed to pure polyurethanes which are biocompatible. These pure polyurethanes comprise the reaction product of:a) a pre-adduct containing NCO groups and comprising the reaction product ofi) a diisocyanate selected from the group consisting of aliphatic diisocyanates, cycloaliphatic diisocyanates, and mixtures thereof, withii) a macrodiol having a molecular weight of from 500 to 10,000 wherein said components i) and ii) reacted at temperatures of from 90.degree.-150.degree. C.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: December 20, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hanns-Peter Muller, Rolf Dhein, Herbert Hugl, Heinz Pudleiner
  • Patent number: 5310557
    Abstract: The present invention relates to shaped articles which contain active compounds and are characterized in that they comprise, as carriers, thermoplastic elastomers based on polyether block amides, as well as customary additives if appropriate, and to processes for their production and to their use for control of pests in animals.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: May 10, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Dieter Brandt, Rolf Dhein, Herbert Hugl, Doris Hackemuller, Wilhelm Stendel
  • Patent number: 5308489
    Abstract: The invention relates to blends of polyether copolycarbonates and other thermoplastics, to their production and to their use for the production of membranes, more particularly for dialysis.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: May 3, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Dhein, Wolfgang Ebert, Herbert Hugl, Holger Ohst
  • Patent number: 5298583
    Abstract: The present invention relates to polymer dyestuffs, i.e. polymer-bound dyestuffs, to a process for their preparation and to their use, for example as markers in analytical procedures. Polymer dyestuffs contain linkable functional groups and are water-soluble under customary conditions of analysis. The polymer portion is usually responsible for this water solubility. The dyestuffs per se are often water-insoluble.
    Type: Grant
    Filed: April 28, 1992
    Date of Patent: March 29, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ludger Heiliger, Hans-Ulrich Siegmund, Herbert Hugl, Antonius Lobberding, Eberhard Kuckert, Bruno Bomer, Thomas Bocker, Gunther Franke
  • Patent number: 5273952
    Abstract: A dye acceptor element for thermosublimation printing comprising a support and a dye acceptor layer consisting essentially of polycarbonate arranged on the support, the polycarbonate containing 30 to 95% by weight aromatic carbonate structural units corresponding to formula I[--O--diphen--O--CO--] (I)in which diphen is the residue of a diphenol containing 6 to 30 and preferably 12 to 24 carbon atoms, and 70 to 5% by weight aliphatic polyether carbonate structural units corresponding to formula II[--O--polyether--O--CO--] (II)in which polyether is the residue of an aliphatic polyether diol having a molecular weight Mn of 600 to 20,000, is distinguished by high color density and a minimal tendency towards adhesion.
    Type: Grant
    Filed: January 24, 1992
    Date of Patent: December 28, 1993
    Assignee: Agfa Gevaert AG
    Inventors: Rolf Wehrmann, Herbert Hugl, Dittmar Nerger
  • Patent number: 5260129
    Abstract: An article of manufacture having a hydrophilic coating is disclosed. To the article which may be made of a thermoplastic or from a thermoset resin there is applied a coating which comprise a segmented, aliphatic-aromatic polyether block copolycarbonates containing aromatic carbonate structural units and aliphatic polyether carbonate structural units. The coating may contain a surfactant.
    Type: Grant
    Filed: December 30, 1991
    Date of Patent: November 9, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Scholl, Herbert Hugl, Wolfgang Nising
  • Patent number: 5238570
    Abstract: Asymmetric semipermeable membranes which consist of aromatic polycondensates having recurring units of the formula(--O--Z--O--Y--).sub.n (I)in whichY is the divalent radical of an aromatic sulphone or of an aromatic ketone and--O--Z--O--is a divalent diphenolate radical which consists to the extent of 0.1-100 mol % of all the diphenolate radicals of those of the formula ##STR1## with the meaning given in the description, are suitable for haemodialysis, haemodiafiltration, haemofiltration, ultrafiltration, microfiltration and reverse osmosis.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: August 24, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Hugl, Rolf Dhein, Ralf Dujardin, Karlheinz Hildenbrand, Knud Reuter
  • Patent number: 5194393
    Abstract: The present invention relates to a sensor with a novel construction for a detection method of molecules labelled with fluorescent dye for detecting these dissolved substances or analytes by energy transfer with a simple fluorescence technique and increased sensitivity in the detection as well as versatile use for different tasks and the possibility of reproducible preparation of films bound to solid surfaces.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: March 16, 1993
    Assignee: Bayar Aktiengesellschaft
    Inventors: Herbert Hugl, Eberhard Kuckert, Dietmar Mobius, Holger Ohst, Meinhard Rolf, Hans J. Rosenkranz, Heinrich C. Schopper, Hans-Ulrich Siegmund, Klaus Sommer, Rolf Wehrmann
  • Patent number: 5160436
    Abstract: Disclosed is a diagnostic test device which comprises a fluid permeable structural support member having on one side thereof a layer of a macroporous membrane comprising polyethyleneimine impregnated with iodate ion and on the other side of the support member having a layer of a microporous membrane having dispersed therein a chromogenic indicator capable of providing a colored response upon being oxidized.The intensity of the colored response is less subject to ascorbate interference due to the activity of the iodate ion.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: November 3, 1992
    Assignee: Miles Inc.
    Inventors: Karlheinz Hildenbrand, Herbert Hugl, Rolf Dhein
  • Patent number: 5070198
    Abstract: The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl andR.sup.2 denotes C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl, or a substituted C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl and their preparation. The compounds can be used in an iron assay system.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: December 3, 1991
    Assignee: Miles Inc.
    Inventors: Piero Fossati, Holger Heidenreich, Herbert Hugl, Klaus Wehling
  • Patent number: 5030697
    Abstract: A polymer-bound linkable dye comprisinga) a water-soluble polymer backbone,b) a dye covalently bound thereto, andc) functional groups which enable the polymer-dye to link covalently with biological materials,in which the water-soluble polymer backbone is a copolymer which contains arcylamide, methacrylamide, N-C.sub.1 -C.sub.4 alkyl(meth)acrylamide, N,N-C.sub.1 -C.sub.4 dialkylacrylamide, N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, N-vinylformamide, N-vinylacetamide, N-vinyl-N-methylacetamide, N-vinyl-O-methylurethane, ethene or vinylmethylether as nonionic monomer blocks. The polymer-bound dye can be linked to a biologically active material such as an antibody or nucleic acid and used analytically.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: July 9, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Hugl, Bruno Bomer, Heinz Kolbl, Florin Seng, Eberhard Kuckert, Gunter Sackmann
  • Patent number: 5017498
    Abstract: The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl andR.sup.2 denotes C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl, or a substituted C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl and their preparation. The compounds can be used in an iron assay system.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: May 21, 1991
    Assignee: Miles Inc.
    Inventors: Piero Fossati, Holger Heidenreich, Herbert Hugl, Klaus Wehling
  • Patent number: 4988616
    Abstract: A method for detecting hydrogen peroxide wherein a sample is contacted with a peroxidase or a peroxidatively-active substance and a redox indicator of the following ##STR1## in which A and D independently of one another represent phenyl, pyridyl or imidazolyl,G represents O, CH.sub.2 or S,m represents the number zero or one, andX represents O, ##STR2## or --NR.sup.1 --NR.sup.2 -- R.sup.1 and R.sup.2, independently of one another, denote hydrogen, alkyl, cycloalkyl, aryl or aralkyl, or --NR.sup.1 R.sup.2 together represent a pyrrolidine, pyrazoline, piperidine, piperazine or morpholine radical andT denotes hydrogen, hydroxyl, alkyl, aryl, alkoxy, phenoxy, SO.sub.3 H, --COOH or ##STR3## whereby a color change is brought out if hydrogen peroxide is present.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Holger Heidenreich, Gerhard Wolfrum, Klaus Wehling, Herbert Hugl
  • Patent number: 4962040
    Abstract: 2-Hydrazono-4,6-dinitrobenzthiazolones of the formula ##STR1## in which X.sub.1 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -hydroxyalkyl, C.sub.1 -C.sub.4 -sulphoalkyl or C.sub.1 -C.sub.4 -sulphatoalkyl, andX.sub.2 represents hydrogen or --SO.sub.2 X.sub.3, whereX.sub.3 may represent hydrogen, C.sub.1 -C.sub.8 -alkyl or optionally substituted aryl andX.sub.1 also represents a double bond between the cyclic nitrogen atom and the carbon atom 2 according to the formula II below: ##STR2## where X.sub.2 has the meaning specified under the above formula. These hydrazones may be employed in the preparation of azo dyestuffs and as color formers for detecting of biological substances, and in the determination of H.sub.2 O.sub.2.
    Type: Grant
    Filed: August 10, 1989
    Date of Patent: October 9, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Hugl, Aloysius Engel, Klaus Wehling
  • Patent number: 4814271
    Abstract: The present invention relates to new chromogenic amino acid esters and peptide esters of hydroxyisoquinolines and hydroxyquinolines, processes for their preparation and the use of the new esters as substrates for the analytical detection of esterolytic and/or proteolytic enzymes, for example in body fluids, the esters being incorporated into test agents, in particular test strips, in a suitable manner. The new esters are particularly used for the detection of leukocytes, in particular in urine.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: March 21, 1989
    Assignee: Miles Inc.
    Inventors: Herbert Hugl, Hans-Volker Runzheimer, Eugen Schnabel, Gerhard Wolfrum
  • Patent number: 4806423
    Abstract: The present invention relates to new chromogenic amino acid esters and peptide esters of hydroxybenzo(iso)thiazoles and hydroxybenzopyrazoles and the use of the new esters as substrates for the analytical detection of esterolytic and/or proteolytic enzymes, for example in body fluids, the esters being incorporated into test agents, in particular test strips, in a suitable manner. The new esters are preferably used for the detection of leukocytes, in particular in urine.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: February 21, 1989
    Assignee: Miles Inc.
    Inventors: Herbert Hugl, Eugen Schnabel