Patents by Inventor Herbert Irschik
Herbert Irschik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8841341Abstract: The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.Type: GrantFiled: September 5, 2008Date of Patent: September 23, 2014Assignee: Helmholtz-Zentrum fuer Infektionsforschung GmbHInventors: Brigitte Kunze, Irene Wagner-Döbler, Herbert Irschik, Heinrich Steinmetz, Dietmar Schummer
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Patent number: 8114864Abstract: The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.Type: GrantFiled: November 9, 2007Date of Patent: February 14, 2012Assignee: Helmholtz-Zentrum Fuer InfektionsforschungInventors: Rolf Jansen, Brigitte Kunze, Herbert Irschik
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Patent number: 7947719Abstract: The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus Sorangium, preferably Sorangium cellulosum.Type: GrantFiled: July 13, 2006Date of Patent: May 24, 2011Assignee: Hemholtz-Zentrum fur Infektionsforschung GmbHInventors: Herbert Irschik, Rolf Jansen, Florenz Sasse
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Publication number: 20110034708Abstract: The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.Type: ApplicationFiled: September 5, 2008Publication date: February 10, 2011Applicant: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBHInventors: Brigitte Kunze, Irene Wagner-Dobler, Herbert Irschik, Heinrich Steinmetz, Dietmar Schummer
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Publication number: 20100113757Abstract: The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.Type: ApplicationFiled: November 9, 2007Publication date: May 6, 2010Applicant: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNGInventors: Rolf Jansen, Brigitte Kunze, Herbert Irschik
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Publication number: 20090311264Abstract: The invention relates to disorazoles of the general formula I, which are employed as medicaments, preferably for the treatment of oncoses, in particular in the case of pharmaceutical resistance to other active compounds and in the case of metastasizing carcinoma. The possible uses are not restricted to oncoses.Type: ApplicationFiled: April 7, 2009Publication date: December 17, 2009Applicant: AEterna Zentaris GmbHInventors: Herbert Irschik, Rolf Jansen, Florenz Sasse, Silke Baasner, Peter Schmidt, Eckhard Gunther
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Publication number: 20070021480Abstract: The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus Sorangium, preferably Sorangium cellulosum.Type: ApplicationFiled: July 13, 2006Publication date: January 25, 2007Inventors: Herbert Irschik, Rolf Jansen, Florenz Sasse
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Publication number: 20060199252Abstract: The present invention relates to nucleic acid sequences and proteins derivable therefrom that have been identified in Sorangium cellulosum, which proteins are catalytically active or participate in the biosynthetic pathway of disorazoles. The invention provides novel sequences which are necessary components of the disorazole biosynthetic pathway in addition to genes dszA-D.Type: ApplicationFiled: January 12, 2006Publication date: September 7, 2006Inventors: Herbert Irschik, Maren Kopp, Rolf Muller
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Publication number: 20040106662Abstract: The invention relates to disorazoles of the general formula I, which are employed as medicaments, preferably for the treatment of oncoses, in particular in the case of pharmaceutical resistance to other active compounds and in the case of metastasizing carcinoma. The possible uses are not restricted to oncoses.Type: ApplicationFiled: August 22, 2003Publication date: June 3, 2004Inventors: Herbert Irschik, Rolf Jansen, Florenz Sasse, Silke Baasner, Peter Schmidt, Eckhard Gunther
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Patent number: 5622979Abstract: The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.Type: GrantFiled: June 7, 1995Date of Patent: April 22, 1997Assignees: Ciba-Geigy Corporation, Gesellschaft fur Biotechnologische Forschung mbHInventors: Gerhard H ofle, Norbert Bedorf, Edgar Forche, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Hans Reichenbach, Florenz Sasse, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Johannes P. Pachlatko
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Patent number: 5610038Abstract: The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.Type: GrantFiled: June 7, 1995Date of Patent: March 11, 1997Assignees: Ciba-Geigy Corporation, Gesellschaft fur Biotechnologische Forschung mbHInventors: Gerhard Hofle, Norbert Bedorf, Edgar Forche, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Hans Reichenbach, Florenz Sasse, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Johannes P. Pachlatko
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Patent number: 5604249Abstract: The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.Type: GrantFiled: June 7, 1995Date of Patent: February 18, 1997Assignees: Ciba-Geigy Corporation, Gesellschaft fur Biotechnologische Forschung mbHInventors: Gerhard H ofle, Norbert Bedorf, Edgar Forche, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Hans Reichenbach, Florenz Sasse, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Johannes P. Pachlatko
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Patent number: 5096922Abstract: The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.Type: GrantFiled: April 23, 1990Date of Patent: March 17, 1992Assignee: Gesellschaft fur Biotechnologische Forschung mbHInventors: Hans Reichenbach, Gerhard Hofle, Hermann Augustiniak, Norbert Bedorf, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Dietmar Schomburg, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Victor Wray
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Patent number: 5023184Abstract: The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.Type: GrantFiled: August 13, 1987Date of Patent: June 11, 1991Assignees: Ciba-Geigy Corporation, Gesellschaft fur Biotechnologische Forschung mbHInventors: Hans Reichenbach, Klaus Gerth, Herbert Irschik, Brigitte Kunze, Gerhard Hofle, Hermann Augustiniak, Norbert Bedorf, Rolf Jansen, Wolfram Trowitzsch-Kienast, Heinrich Steinmetz
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Patent number: 4987072Abstract: The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.Type: GrantFiled: September 11, 1986Date of Patent: January 22, 1991Assignee: Gesellschaft fur Biotechnologische Forschung GmbHInventors: Hans Reichenbach, Gerhard Hofle, Hermann Augustiniak, Norbert Bedorf, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Dietmar Schomburg, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Victor Wray