Patents by Inventor Herbert Koller
Herbert Koller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10017526Abstract: Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or their hydrolysis/condensation products or mixture thereof, with a halosilane.Type: GrantFiled: June 29, 2015Date of Patent: July 10, 2018Assignee: WACKER CHEMIE AGInventors: Michael Stepp, Herbert Koller
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Publication number: 20170166595Abstract: Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or their hydrolysis/condensation products or mixture thereof, with a halosilane.Type: ApplicationFiled: June 29, 2015Publication date: June 15, 2017Applicant: Wacker Chemie AGInventors: Michael STEPP, Herbert KOLLER
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PROCESS FOR THE BODY-HYDROPHOBIZATION OF BUILDING MATERIALS COMPRISING SOLID ORGANOSILICON COMPOUNDS
Publication number: 20140230698Abstract: Body-hydrophobing of mineral building compositions prepared from water curable mineral materials such as cement and plaster are obtained by admixing into the curable composition an organosilicon compound prepared by reacting a hydrocarbylhalosilane or hydrocarbylhydrocarbyloxysilane with a gylcol or polyglycol in a mol ratio of halo or hydrocarbyloxy radicals to hydroxyl radicals of 0.3 to 1.3. The organosilicon compounds are solid at 20° C.Type: ApplicationFiled: October 1, 2012Publication date: August 21, 2014Applicant: Wacker Chemie AGInventors: Michael Stepp, Herbert Koller, Daniel Schildbach -
Patent number: 8796491Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.Type: GrantFiled: August 7, 2009Date of Patent: August 5, 2014Assignee: Merz Pharma GmbH & Co. KGaAInventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin
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Patent number: 8784847Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.Type: GrantFiled: April 16, 2010Date of Patent: July 22, 2014Assignee: Merz Pharma GmbH & Co. KGaAInventors: Markus Henrich, Simona Negura, Gergely Tasi, Pal Kocsan, Federico Sbrogio, Michael Pyerin, Herbert Koller
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Patent number: 8759581Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.Type: GrantFiled: June 28, 2010Date of Patent: June 24, 2014Assignee: Merz Pharma GmbH & Co. KGaAInventors: Herbert Koller, Michael Pyerin
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Publication number: 20130123541Abstract: Method of preparing 3,3,5,5-tetramethylcyclohexanone comprising step (i): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone in the presence of methylmagnesium chloride. The thus prepared 3,3,5,5-tetramethylcyclohexanone may be employed in a method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 28, 2010Publication date: May 16, 2013Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
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Publication number: 20120130130Abstract: The method of producing a salt of 1-amino-1,3,3,5,5-pentamethylcyclohexane comprising steps (i) to (v): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone; (ii) converting 3,3,5,5-tetramethylcyclohexanone obtained in step (i) to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane; (iii) converting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane obtained in step (ii) to 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane; (iv) converting 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane obtained in step (iii) to 1-amino-1,3,3,5,5-pentamethylcyclohexane; wherein at least one of 3,3,5,5-tetramethylcyclohexanone, 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane, 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, is not subjected to a purification step.Type: ApplicationFiled: June 28, 2010Publication date: May 24, 2012Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Mchael Pyerin, Federico Sbrogio
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Publication number: 20120130127Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.Type: ApplicationFiled: June 28, 2010Publication date: May 24, 2012Applicant: MER PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Michael Pyerin
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Publication number: 20120130131Abstract: The invention relates to a method of producing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof comprising the step of heating a mixture comprising 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, thiourea and water.Type: ApplicationFiled: June 28, 2010Publication date: May 24, 2012Inventors: Herbert Koller, Michael Pyerin
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Publication number: 20120123166Abstract: Method of preparing 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane comprising step (ii): (ii) converting 3,3,5,5-tetramethylcyclohexanone to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane by using methylmagnesium chloride. 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane may be used for preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 28, 2010Publication date: May 17, 2012Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
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Publication number: 20120116125Abstract: Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or pharmaceutically acceptable salt thereof, comprising at least two steps selected from the following steps (i) to (iv): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone in the presence of methylmagnesium chloride; (ii) converting 3,3,5,5-tetramethylcyclohexanone to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane in the presence of methylmagnesium chloride; (iii) converting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane to 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane in the presence of chloroacetonitrile in acidic solution; (iv)converting 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane to 1-amino-1,3,3,5,5-pentamethylcyclohexane in the presence of thiourea in water.Type: ApplicationFiled: June 28, 2010Publication date: May 10, 2012Applicant: MERZ PHARMA GMBH & CO. KGAAInventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
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Publication number: 20120100184Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.Type: ApplicationFiled: April 16, 2010Publication date: April 26, 2012Applicant: MERZ PHARMA GmbH & CO.KGaAInventors: Markus Henrich, Simona Negura, Gergely Tasi, Pal Kocsan, Federico Sbrogio, Michael Pyerin, Herbert Koller
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Publication number: 20110263900Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine:substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.Type: ApplicationFiled: August 7, 2009Publication date: October 27, 2011Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin
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Patent number: 6207833Abstract: The invention relates to a single stage method for preparing 2-(quinolylthio)acetic acid and its salts by reacting 2-chloroquinoline and mercaptoacetic acidType: GrantFiled: June 23, 2000Date of Patent: March 27, 2001Assignee: Loba Feinchemie AGInventor: Herbert Koller