Patents by Inventor Herbert Koller

Herbert Koller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10017526
    Abstract: Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or their hydrolysis/condensation products or mixture thereof, with a halosilane.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: July 10, 2018
    Assignee: WACKER CHEMIE AG
    Inventors: Michael Stepp, Herbert Koller
  • Publication number: 20170166595
    Abstract: Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or their hydrolysis/condensation products or mixture thereof, with a halosilane.
    Type: Application
    Filed: June 29, 2015
    Publication date: June 15, 2017
    Applicant: Wacker Chemie AG
    Inventors: Michael STEPP, Herbert KOLLER
  • Publication number: 20140230698
    Abstract: Body-hydrophobing of mineral building compositions prepared from water curable mineral materials such as cement and plaster are obtained by admixing into the curable composition an organosilicon compound prepared by reacting a hydrocarbylhalosilane or hydrocarbylhydrocarbyloxysilane with a gylcol or polyglycol in a mol ratio of halo or hydrocarbyloxy radicals to hydroxyl radicals of 0.3 to 1.3. The organosilicon compounds are solid at 20° C.
    Type: Application
    Filed: October 1, 2012
    Publication date: August 21, 2014
    Applicant: Wacker Chemie AG
    Inventors: Michael Stepp, Herbert Koller, Daniel Schildbach
  • Patent number: 8796491
    Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: August 5, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin
  • Patent number: 8784847
    Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: July 22, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Markus Henrich, Simona Negura, Gergely Tasi, Pal Kocsan, Federico Sbrogio, Michael Pyerin, Herbert Koller
  • Patent number: 8759581
    Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: June 24, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Herbert Koller, Michael Pyerin
  • Publication number: 20130123541
    Abstract: Method of preparing 3,3,5,5-tetramethylcyclohexanone comprising step (i): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone in the presence of methylmagnesium chloride. The thus prepared 3,3,5,5-tetramethylcyclohexanone may be employed in a method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 16, 2013
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
  • Publication number: 20120130130
    Abstract: The method of producing a salt of 1-amino-1,3,3,5,5-pentamethylcyclohexane comprising steps (i) to (v): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone; (ii) converting 3,3,5,5-tetramethylcyclohexanone obtained in step (i) to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane; (iii) converting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane obtained in step (ii) to 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane; (iv) converting 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane obtained in step (iii) to 1-amino-1,3,3,5,5-pentamethylcyclohexane; wherein at least one of 3,3,5,5-tetramethylcyclohexanone, 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane, 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, is not subjected to a purification step.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 24, 2012
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Herbert Koller, Mchael Pyerin, Federico Sbrogio
  • Publication number: 20120130127
    Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 24, 2012
    Applicant: MER PHARMA GmbH & CO. KGaA
    Inventors: Herbert Koller, Michael Pyerin
  • Publication number: 20120130131
    Abstract: The invention relates to a method of producing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof comprising the step of heating a mixture comprising 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, thiourea and water.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 24, 2012
    Inventors: Herbert Koller, Michael Pyerin
  • Publication number: 20120123166
    Abstract: Method of preparing 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane comprising step (ii): (ii) converting 3,3,5,5-tetramethylcyclohexanone to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane by using methylmagnesium chloride. 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane may be used for preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 17, 2012
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
  • Publication number: 20120116125
    Abstract: Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or pharmaceutically acceptable salt thereof, comprising at least two steps selected from the following steps (i) to (iv): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone in the presence of methylmagnesium chloride; (ii) converting 3,3,5,5-tetramethylcyclohexanone to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane in the presence of methylmagnesium chloride; (iii) converting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane to 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane in the presence of chloroacetonitrile in acidic solution; (iv)converting 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane to 1-amino-1,3,3,5,5-pentamethylcyclohexane in the presence of thiourea in water.
    Type: Application
    Filed: June 28, 2010
    Publication date: May 10, 2012
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
  • Publication number: 20120100184
    Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 26, 2012
    Applicant: MERZ PHARMA GmbH & CO.KGaA
    Inventors: Markus Henrich, Simona Negura, Gergely Tasi, Pal Kocsan, Federico Sbrogio, Michael Pyerin, Herbert Koller
  • Publication number: 20110263900
    Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine:substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.
    Type: Application
    Filed: August 7, 2009
    Publication date: October 27, 2011
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin
  • Patent number: 6207833
    Abstract: The invention relates to a single stage method for preparing 2-(quinolylthio)acetic acid and its salts by reacting 2-chloroquinoline and mercaptoacetic acid
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: March 27, 2001
    Assignee: Loba Feinchemie AG
    Inventor: Herbert Koller