Patents by Inventor Herbert Koppe

Herbert Koppe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 3959338
    Abstract: Racemic or optically active compounds of the formula ##EQU1## wherein R.sub.1 is hydrogen, halogen, alkyl or 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, andR.sub.2 is straight or branched hydroxyalkyl of 3 to 6 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful .beta.-adrenergic receptor blocking agents and hypotensives.
    Type: Grant
    Filed: March 18, 1974
    Date of Patent: May 25, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Koppe, Helmut Stahle, Werner Kummer, Werner Traunecker
  • Patent number: 3954872
    Abstract: Compounds of the formula ##EQU1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, andR.sub.1 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anticonvulsives and antiarrhythmics in warmblooded animals.
    Type: Grant
    Filed: October 1, 1974
    Date of Patent: May 4, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Koppe, Karl Zeile, Werner Kummer, Helmut Stahle, Peter Danneberg
  • Patent number: 3950523
    Abstract: Pharmaceutical compositions containing, as an active ingredient, a compound of the formula ##SPC1##WhereinR.sub.1 is phenyl or mono-, di or tri-substituted phenyl, the substituents being each halogen, methyl, methoxy or trifluoromethyl, andR.sub.2 is hydrogen, phenyl or halo-phenyl;And a method of using the same as antidepressants.
    Type: Grant
    Filed: February 10, 1975
    Date of Patent: April 13, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Wolfgang Hoefke
  • Patent number: 3940489
    Abstract: A composition having bradycardia and isoproterenol antagonistic activity comprising at least one compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##EQU1## wherein R is selected from the group consisting of --(CH.sub.2).sub.x --CN where x is an integer from 0 to 3, COOH and COOR' where R' is alkyl of 1 to 4 carbon atoms; R.sub.1 is selected from the group consisting of hydrogen, alkoxy and alkylthio of 1 to 4 carbon atoms, --CN and alkenyl and alkynyl of 2 to 4 carbon atoms and R.sub.2 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 4 carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers and a major amount of a pharmaceutical carrier and a method of producing bradycardia and suppressing tachycardia effects of N-isopropyl-noradrenaline in warm-blooded animals.
    Type: Grant
    Filed: September 3, 1974
    Date of Patent: February 24, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Koppe, Albrecht Engelhardt, Karl Zeile
  • Patent number: 3937706
    Abstract: Compounds of the formula ##EQU1## wherein n is 4 or 5, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as .beta.-adrenergic receptor blocking agents.
    Type: Grant
    Filed: November 29, 1972
    Date of Patent: February 10, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Karl Zeile, Albrecht Engelhardt, Werner Traunecker
  • Patent number: 3937717
    Abstract: 2-Phenylamino-imidazolines-(2) of the formula ##SPC1##Wherein R, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, trifluoromethyl and cyano and one of R.sub.3 and R.sub.4 being hydrogen while the other is ##EQU1## and R.sub.5 is selected from the group consisting of hydrogen, methyl and ethyl and their non-toxic, pharmaceutically acceptable acid addition salts which have analgesic and blood pressure reducing properties and their preparation.
    Type: Grant
    Filed: February 11, 1974
    Date of Patent: February 10, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus