Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.

Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

Abstract: Fermentation media, employed for its ability to grow recombinant mammalian cells to high densities and abet their expression of recombinant protein drug products at high titers, are rendered free of active viruses by treatment with low levels of light, levels at which the essential media properties are retained.

Abstract: The invention relates to a glove, especially a disposable glove. Said glove comprises at least two plastic films (6, 7) of substantially the same dimensions that are firmly linked with each other at least in the lateral marginal zones (8), thereby defining the inner (10) and the outer (9) face of the glove and leaving free a glove opening (11). Said glove is further characterized by an absorbing exterior layer (12) that is applied on the outer surface that pertains to the back of the hand and/or the inner surface that permits to the palm.

Abstract: In a folding blade shaft of a folding cylinder of a drum folding apparatus, the drive shaft and spindle are connected so that the slanting of these parts does not cause any damage to the machine. To this end, the drive shaft and the spindle are connected to each other via a disk packet and centered by a radial rocker bearing.

Abstract: A control installation for the dose rate of the x-ray tube and, thus, for the mean brightness of the output image of the x-ray image intensifier is present. Further, switching circuitry is provided, by means of which a preprogrammed rated value for the dose rate is selected, which rated value lies below the dose rate required for a diagnosis.

Abstract: An X-ray diagnostic installation employed for fluoroscopy and exposures, wherein the prevailing exposure voltage may be determined by a user. The output signal of a function generator controls an arrangement for indication of the prevailing exposure voltage. This indication may be effectuated by means of a digital recording arrangement. In an embodiment of the invention, a transmission arrangement between the output of the function generator and the input of a digital recording arrangement, may comprise a coding device for the output signals. Additionally, the installation also has a construction necessitating relatively low power requirements between the X-ray diagnostic apparatus and a remotely located control panel by providing a coding and decoding arrangement intermediate the coding device and the digital recording arrangement.

Abstract: An X-ray diagnosing apparatus has several photographing systems which can be selectively connected to a common generator. Each system is provided with an operating desk for setting the photographing data and means for connecting the corresponding X-ray tube to the generator and for operating further auxiliary devices. The invention is particularly characterized in that each operating desk has an indicating area with at least one signaling lamp for the correlated X-ray tube and the correlated auxiliary devices. Furthermore, means are provided for operating the signaling lamps to indicate operational readiness and a proper operation of the X-ray tube and auxiliary devices.