Patents by Inventor Herbert Silberger

Herbert Silberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
    Publication number: 20170327504
    Abstract: The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.
    Type: Application
    Filed: October 28, 2015
    Publication date: November 16, 2017
    Applicant: Sandoz AG
    Inventors: Christopher Rose, Herbert Silberger, Erwin Schreiner, Wolfgang Felzmann, Nenad Maras