Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The invention relates to hollow balls having shells comprising a sintered inorganic material, such as metals, metal oxides or ceramic, and to methods for producing lightweight structural components using such hollow balls. According to the object of the invention, the application area is to be widened, processing to form structural components is to be made technologically simpler and the properties of the hollow balls and of the structural components produced therewith are to be improved for specific applications. For this purpose, an additional solid functional layer is formed on a shell on the hollow balls. The functional-layer material can then be made able to flow and plastically and/or elastically deformed as a result of a physical and/or chemical treatment.

Abstract: The invention relates to hollow balls having shells comprising a sintered inorganic material, such as metals, metal oxides or ceramic, and to methods for producing lightweight structural components using such hollow balls. According to the object of the invention, the application area is to be widened, processing to form structural components is to be made technologically simpler and the properties of the hollow balls and of the structural components produced therewith are to be improved for specific applications. For this purpose, an additional solid functional layer is formed on a shell on the hollow balls. The functional-layer material can then be made able to flow and plastically and/or elastically deformed as a result of a physical and/or chemical treatment.

Abstract: According to the invention, the shaped bodies are comprised of at least one heavy metal, preferably Fe, Ni, Co, Sn, Mo or W which can be reduced from a corresponding metallic compound at a temperature of less than 1 500° C. The shaped bodies have an outer diameter ranging from 0.05 to 0.5 mm, and a diameter-to-wall thickness ratio of 0.5 to 3%.

Abstract: Melting furnace (1) for the production of strand-cast ingots (17, 18) in a protective gas atmosphere, has a charging apparatus (8) for feeding starting material (11) into a melting area (14). Within a melting chamber provided with a chamber floor (2d) and at least one energy source (4,5) there is situated a strand-casting mold (15) for the transformation of the melt to an ingot (17, 18) and underneath the strand-casting mold is disposed an offbearing apparatus (25) for offbearing the ingot, and an offbearing chamber enveloping the ingot and the offbearing apparatus. To solve the problem of operating such a melting furnace virtually continuously, the strand-casting mold (15) together with at least one additional strand-casting mold (16) is disposed in the chamber flow (2d) in such a manner that each of the strand-casting molds (15, 16) can be brought into the drop path of the melt by a preferably horizontal relative movement.

Abstract: Metal particles are remelted in a fusion zone by electron beam bombardment and formed in a continuous casting mould. Furthermore,(a) the metal particles are evenly distributed over the horizontally positioned floor of a fusion ladle,(b) the metal particles are joined together into a plate-shaped structure by means of the electron beam, whereafter(c) the floor of the fusion ladle is moved into a position inclined in relation to the horizontal,(d) the electron beam is guided upwards over the sloping, plate-shaped particle structure so that this is firstly preheated and fused directly thereafter, while(e) the molten metal running over the lower part of the floor is simultaneously kept liquid by electron beam bombardment, whereafter(f) the electron beam is guided back downwards over the sloping floor of the fusion ladle, and(g) the floor of the fusion ladle is returned to the horizontal starting position and is once again charged with metal particles according to feature (a).

Abstract: High-purity metal powder is made by the electron beam melting of a starting material in rod form in a vacuum wherein the molten metal is momentarily caught on a spinning plate rotating at high speed and flung therefrom and thereafter solidified by cooling. The metal on the spinning plate is bombarded with an electron beam that is so focused and periodically deflected that its focal spot is many times smaller than the diameter of the spinning plate. The beam deflection between the rotational center of the spinning plate and its marginal area is performed such that the spinning plate is scanned in a zone that extends radially of the axis of rotation of the spinning plate and is small in relation to its diameter. Cooling of the metal particles to the point of solidification is accomplished by radiation loss.

Abstract: Coupling valve for joining stationary and movable evacuatable chambers having confronting chamber walls displaced parallel with respect to each other. A first frame is fastened to one chamber wall and is joined by a resilient member to a second movable frame which can be brought into engagement with the other chamber wall. The movable frame is provided with at least one actuator by which it can be tightened against the confronting chamber wall.

Abstract: Method and apparatus for vacuum depositing thin films on substrates which are located above 500.degree. C. by electron beam heating during the deposition. The substrates are positioned above an evaporating crucible filled with a bath of the material being evaporated which is also heated by electron beams. The electron beams are deflected at an angle of less than 80.degree. onto approximately one-half of the bath surface situated between the axis of symmetry and the end of the evaporating crucible.

Abstract: Method for vaporizing alloys containing metals having different vapor pressures from elongated vaporizing crucibles which are fed with the alloy to be vaporized in rod form at several points along the length of the crucible. The alloy is vaporized by direct bombardment of the molten bath surface with electron beams periodically deflected according to a pattern for the deposition of the alloy coating material on a plurality of substrates positioned above the vaporizing crucible. The proportional composition of the alloy to be vaporized is regulated differently over the length of the crucible such that the alloy component with the lowest boiling point (or the highest vapor pressure) is in a smaller proportion in the alloy to be vaporized which is fed to the center of the vaporizing crucible than in the alloy fed to the ends of the vaporizing crucible.

Abstract: Method and device for determining the radiation parameters of a focused beam of charged particles guided periodically over a target surface, especially in an electron beam melting and vaporizing system wherein the target is the surface of a melt. At least one probe is positioned in front of the target surface in the direction of radiation and within the beam trace, the probe being connected to an electrical display device. The output signal of the probe is displayed via a cathode ray tube and the reversal point of the charged-particle beam is determined on the basis of the time interval between the signal peaks in conjunction with the velocity of the beam movement.

Abstract: Method for vacuum depositing corrosion and oxidation resistant alloy coatings on turbine buckets having leading edges and trailing edges, with simultaneous rotation of the turbine buckets about their longitudinal axis in a vapor stream above a vapor source. The time of stay of each element of the surface above the vapor source is varied during a 360.degree. rotation such that it is shortest when the leading edges and the trailing edges are pointed towards the vapor source and longest when the concave and convex flanks are presented to it.

Abstract: Method for evaporating melts of alloys of metals of different vapor pressures from continuously fed, large-area evaporating crucibles by direct bombardment of the bath surface with focused electron beams which are periodically deflected according to a pattern. The alloy material is deposited on a plurality of substrates such as turbine blades which are positioned in a field above the evaporating crucible with local adaptation of the energy density to the thermal economy of the melt bath. At least one electron beam is deflected onto at least two substantially rectangular beam fields and is guided in each of these fields through a line raster at a frequency of at least 100 Hz while shifting periodically from one to the other field with a shift frequency of at most 5 Hz.

Abstract: Pass-through heating device for vacuum coating apparatus having a heating chamber with at least one heating device, a thermal barrier positioned between the walls of the heating chamber and the heating device parallel to the longitudinal axis of the coating apparatus.

Abstract: High-purity metal powder is made by the electron beam melting of a starting material in rod form in a vacuum wherein the molten metal is momentarily caught on a spinning plate rotating at high speed and flung therefrom and thereafter solidified by cooling. The metal on the spinning plate is bombarded with an electron beam that is so focused and periodically deflected that its focal spot is many times smaller than the diameter of the spinning plate. The beam deflection between the rotational center of the spinning plate and its marginal area is performed such that the spinning plate is scanned in a zone that extends radially of the axis of rotation of the spinning plate and is small in relation to its diameter. Cooling of the metal particles to the point of solidification is accomplished by radiation loss.

Abstract: Method for coating metal substrates with alloys wherein the substrates are at a temperature above 500.degree. C. The coating process is interrupted temporarily at least once and the substrates are allowed to cool by at least 30.degree. C. Before the beginning of or during the resumed coating process, the substrate temperature is substantially restored.