Abstract: A wheel locking device for use on a wheelchair, including a locking bar connected to a shaft that is movably axially and rotationally within a fixed tube, by a single operating handle. As the operating handle is moved from a release position to a locking position, the shaft is first axially translated by means of a cam on the handle, and simultaneously rotated by means of a guide pin extending radially from the shaft and engaging a slot in the tube, to move the locking bar from a retracted position well clear of a wheel of the chair to an operative position located transversely with respect to the wheel circumference. Further movement of the operating handle translates the locking bar transversely into locking engagement with the wheel.