Patents by Inventor Herbert Wieder

Herbert Wieder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11280756
    Abstract: A method for detecting an interferent contribution in a biosensor is disclosed. Herein, the biosensor has a first electrode (112), a second electrode, and a third electrode (114), wherein the first electrode (112) and the second electrode are covered by a membrane, wherein the first electrode (112) further includes an enzyme or wherein the first electrode (112) is covered by an enzyme layer. Further, the first electrode (112), the second electrode, and the third electrode (114) are connected via a potentiostat, wherein, in a normal operational mode, via the potentiostat an electrical potential difference is applied between the first electrode (112) and the second electrode in a manner that the first electrode (112) allows for oxidative processes and the third electrode (114) allows for reductive processes.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: March 22, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Christian Ringemann, Herbert Wieder
  • Publication number: 20210295515
    Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Inventors: Max Berg, Fredrik Hailer, Bernd Limburg, Daniel Sieffert, Herbert Wieder, Peter Seelig, Benhur Aysin, Siva Chittajallu
  • Patent number: 11098339
    Abstract: A method for testing enzyme based electrochemical sensors wherein an electrochemical sensor is provided. A measurement setup is provided, which is operatively coupled to the electrochemical sensor, providing an output signal Z, e.g. a measured signal current, of the electrochemical sensor; and the electrochemical sensor is suitably contacted with a test solution comprising a certain concentration of the primary analyte. The electrochemical sensor is subjected to a certain swept range of temperatures T; an output signal Z is measured for different temperature values T; a derivative Z? of the output signal Z as a function of temperature T, or inverse temperature 1/T, is determined; and a relative derivate Z?/Z at a temperature T, or inverse temperature 1/T, is determined as the ratio between derivative Z? and output signal Z.
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: August 24, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventor: Herbert Wieder
  • Publication number: 20210258565
    Abstract: A method of evaluating the suitability of a mobile device for performing an analytical measurement based on a color formation reaction. The capability of the mobile device to have relevant settings of the mobile device controlled by software running on the mobile device is evaluated. The relevant settings pertain to image raw data processing steps to be carried out by the mobile device and may include a color space transformation and a tone mapping transformation. When the evaluation indicates that the mobile device is capable of having the relevant settings controlled by the software, control information indicating that the mobile device is suitable for performing the analytical measurement is provided. When the evaluation indicates that the mobile device is not capable of having the relevant settings controlled by the software, control information indicating that the mobile device is unsuitable for performing the analytical measurement is provided.
    Type: Application
    Filed: May 5, 2021
    Publication date: August 19, 2021
    Inventors: Bernd Limburg, Herbert Wieder, Max Berg, Simon Wetzel, Daniel Sieffert, Fredrik Hailer, Christian Melchinger, Zied Guermazi
  • Publication number: 20200178868
    Abstract: A method for detecting in-vivo properties of a biosensor. In the inventive method, a sensitivity-to-admittance relation is provided and a raw current in the biosensor is measured. An in-vivo current response is also measured at first and second operating points. A time constant ? is determined by the electrical capacitance C of the working electrode and the electrical resistance RM of the membrane by ?=RM·C. The first and second operating points are selected below and above ?, respectively. An analyte value in a sample of a body fluid is determined by using the raw current and compensating sensitivity drift in the biosensor, which in turn is compensated by using the measured value for the raw current and a corrected value for the sensitivity. The failsafe operation of the biosensor is monitored by using the in-vivo current response measured at the first and second operating points.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 11, 2020
    Inventors: Ulrich Mueller, Herbert Wieder, Alexander Poggenwisch, Uli Delventhal, Andreas Knoerzer
  • Publication number: 20190177764
    Abstract: A method for testing enzyme based electrochemical sensors for quantitative detection of analytes in aqueous solutions, wherein an electrochemical sensor is provided, with a working electrode (1) and a counter electrode, the working electrode comprising an electrical conductor (3), a solid-state matrix (4) being electrically connected with said conductor and containing an immobilized enzyme able to catalytically convert a primary analyte into a secondary analyte that can be oxidised or reduced when a suitable potential is applied at the working electrode, and a membrane (5) covering said matrix and separating it from the outside. The membrane is permeable for the primary analyte, such that primary analyte molecules present in an aqueous solution with which the working electrode is contacted can pass through the membrane to the matrix, where they can be catalytically converted into second analyte molecules.
    Type: Application
    Filed: July 4, 2017
    Publication date: June 13, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventor: Herbert Wieder
  • Publication number: 20190154620
    Abstract: The present invention relates to a biosensor for determining an analyte comprising a substrate, a working electrode comprising an electrically conductive pad in conductive contact with a mediator layer, and an enzyme layer in diffusion-enabling contact with said mediator layer, wherein said mediator layer is an electrodeposited mediator layer, and wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent. The present invention further relates to a method for manufacturing a biosensor, comprising providing a substrate having at least one conductive pad, electrodepositing a mediator layer onto at least part of said conductive pad, wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent, and depositing an enzyme layer onto at least part of said mediator layer. Moreover, the present invention relates to uses and methods related to the biosensor of the present invention.
    Type: Application
    Filed: June 28, 2017
    Publication date: May 23, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventor: Herbert Wieder
  • Publication number: 20190117135
    Abstract: Disclosed is a method for initializing an analyte measurement system (1, 2, 3), the analyte measurement system (1, 2, 3) being designed for continuous in-vivo measurement of a body fluid analyte concentration.
    Type: Application
    Filed: May 8, 2017
    Publication date: April 25, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventor: Herbert Wieder
  • Publication number: 20190079044
    Abstract: A method for detecting an interferent contribution in a biosensor is disclosed. Herein, the biosensor has a first electrode (112), a second electrode, and a third electrode (114), wherein the first electrode (112) and the second electrode are covered by a membrane, wherein the first electrode (112) further includes an enzyme or wherein the first electrode (112) is covered by an enzyme layer. Further, the first electrode (112), the second electrode, and the third electrode (114) are connected via a potentiostat, wherein, in a normal operational mode, via the potentiostat an electrical potential difference is applied between the first electrode (112) and the second electrode in a manner that the first electrode (112) allows for oxidative processes and the third electrode (114) allows for reductive processes.
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Inventors: Christian Ringemann, Herbert Wieder
  • Publication number: 20150099954
    Abstract: Sensor elements are provided for determining at least one analyte concentration in a body fluid. The sensor elements are at least partially implantable into a body tissue and have a substrate and at least two electrodes. One electrode is a working electrode having at least one conductive pad applied to the substrate and at least one electrically conductive sensor material is applied to the conductive pad that includes at least one detector substance adapted to perform an electrically detectable electrochemical detection reaction with the analyte. Another electrode is a counter electrode having at least one counter electrode conductive pad applied to the substrate. The sensor elements also include at least one electrically insulating material that surrounds at least the counter electrode on all sides, where a height of the electrically insulating material at least equals a height of the counter electrode conductive pad.
    Type: Application
    Filed: December 10, 2014
    Publication date: April 9, 2015
    Inventors: Sabine Achmann, Holger Kotzan, Ulrich Mueller, Monika Strasser, Herbert Wieder
  • Patent number: 8777872
    Abstract: A diagnostic system has a diagnostic module with an integrated lancet system and a magazine module separate from the diagnostic module. The diagnostic device also has a connecting device that is used for tensioning the lancet system.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: July 15, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Grogor Bainczyk, Michael Marquant, Herbert Wieder
  • Patent number: 8692119
    Abstract: An analysis device for analysis of a sample on a test element is provided that comprises at least one component configured to make electrical contact with at least one other component for electrical transmission therebetween. The at least one component generally comprises an injection-molded circuit mount, also called an MID, or molded interconnect device.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: April 8, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Riebel, Manfred Augstein, Gregor Bainczyk, Albert Grosser, Oliver Kube, Dieter Meinecke, Bruno Thoes, Herbert Wieder
  • Patent number: 8594760
    Abstract: The measuring system for in vivo monitoring of an analyte concentration with malfunction detection, comprises an electrode system, a potentiostat and an evaluation unit. The electrode system has a working electrode, a reference electrode, and a counter electrode. The potentiostat is for adjusting a difference of potential between the electric potential of the working electrode and the electric potential of the reference electrode to a specified value and for measuring an electric current flowing between the working electrode and the counter electrode. The potentiostat comprises a working electrode terminal for connection to the working electrode, a reference electrode terminal for connection to the reference electrode, and a counter electrode terminal for connection to the counter electrode. The evaluation unit monitors the electric potential of the counter electrode and generates a malfunction signal when said potential is outside a specified reference range. A method of operation is also disclosed.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: November 26, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Herbert Wieder, Michael Marquant
  • Patent number: 8545774
    Abstract: An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: October 1, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Riebel, Bruno Robert Thoes, Manfred Augstein, Herbert Wieder, Gregor Bainczyk
  • Patent number: 8535511
    Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: September 17, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christopher D. Wilsey, Mitali Ghoshal, Herbert Wieder
  • Patent number: 8330046
    Abstract: An analysis device for analysis of a sample on a test element is provided that comprises at least one component configured to make electrical contact with at least one other component for electrical transmission therebetween. The at least one component generally comprises an injection-molded circuit mount, also called an MID, or molded interconnect device.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: December 11, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Riebel, Manfred Augstein, Gregor Bainczyk, Albert Grosser, Oliver Kube, Dieter Meinecke, Bruno Thös, Herbert Wieder
  • Patent number: 8283175
    Abstract: A test device for determining the concentration of at least one analyte in a sample using a element is proposed. The test device can be used particularly for glucose measurement, in particular blood glucose measurement, cholesterol measurement and/or coagulation measurement. The test device according to the invention comprises a housing with a closed state and an opened state, and a storage device for receiving at least one test element. The at least one test element is typically designed as a strip-shaped test element, and the storage device typically comprises a magazine. The magazine comprises a plurality of cavities, and the test elements are received substantially parallel to one another in the cavities. A measuring device and a dispensing device are also provided. The dispensing device comprises means for conveying the at least one test element from at least one storage position of the storage device during opening of the housing.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: October 9, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gregor Bainczyk, Thomas Eisele, Herbert Wieder
  • Publication number: 20110290670
    Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
    Type: Application
    Filed: August 12, 2011
    Publication date: December 1, 2011
    Inventors: Christopher D. Wilsey, Mitali Ghoshal, Herbert Wieder
  • Patent number: 8008037
    Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 30, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christopher D. Wilsey, Mitali Ghoshal, Herbert Wieder
  • Publication number: 20100236941
    Abstract: An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.
    Type: Application
    Filed: June 1, 2010
    Publication date: September 23, 2010
    Inventors: Stefan Riebel, Bruno Robert Thoes, Manfred Augstein, Herbert Wieder, Gregor Bainczyk