Patents by Inventor Herchel Smith

Herchel Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dithioketal derivatives of 13-polycarbonalkylgon-4-en-3-ones
    Patent number: 4005078
    Abstract: Novel 3-thioketals of 13-polycarbonalkyl-17-ethynyl-17-hydroxygon-4-ene and 13-polycarbonalkyl-17-chlorethynyl-17-hydroxygon-4-ene, with improved separation of activities, i.e. maximizing progestational and minimizing androgenic action, are prepared from the corresponding 3-carbonyl compounds by treatment with dithioethylene ketal in the presence of an acid catalyst.
    Type: Grant
    Filed: June 29, 1966
    Date of Patent: January 25, 1977
    Assignee: Herchel Smith
    Inventors: Gordon Alan Hughes, Herchel Smith
  • Synthesis of gon-4-enes
    Patent number: 4002746
    Abstract: 1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17.alpha.-ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.
    Type: Grant
    Filed: January 15, 1964
    Date of Patent: January 11, 1977
    Assignee: Herchel Smith
    Inventors: Gordon Alan Hughes, Herchel Smith
  • Synthesis of 13-alkyl-gon-4-ones
    Patent number: 3959322
    Abstract: The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
    Type: Grant
    Filed: August 11, 1964
    Date of Patent: May 25, 1976
    Assignee: Herchel Smith
    Inventors: Gordon Alan Hughes, Herchel Smith
  • Indole fused heterocyclic diuretic compounds
    Patent number: 3943148
    Abstract: Substituted 1,2,4,5,6,7,8,9-octahydro-3H-azecino[5,4-b]-indoles and substituted 1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]-indoles are prepared by cleavage of the corresponding quaternary alkyl iodide salts with lithium in liquid ammonia. The products possess diuretic activity.
    Type: Grant
    Filed: August 10, 1972
    Date of Patent: March 9, 1976
    Assignee: American Home Products Corporation
    Inventors: David R. Herbst, Herchel Smith