Patents by Inventor Heribert Hellstern

Heribert Hellstern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 9493512
    Abstract: The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 15, 2016
    Assignee: NOVARTIS AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, Robert Schreiber, Hans Stettler
  • Processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 9278997
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: March 8, 2016
    Assignee: NOVARTIS AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, John Lopez, Robert Schreiber, Christian Sprecher, Hans Stettler
  • Solution Phase Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
    Publication number: 20150218224
    Abstract: The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: April 15, 2015
    Publication date: August 6, 2015
    Applicant: NOVARTIS AG
    Inventors: Murat ACEMOGLU, Heribert HELLSTERN, Felix KOLLMER, Robert SCHREIBER, Hans STETTLER
  • Somatostatin Analogues
    Publication number: 20150218223
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: April 8, 2015
    Publication date: August 6, 2015
    Applicant: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 9067978
    Abstract: The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: June 30, 2015
    Assignee: NOVARTIS AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, Robert Schreiber, Hans Stettler
  • ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES
    Publication number: 20150141615
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 21, 2015
    Applicant: NOVARTIS AG
    Inventors: Murat ACEMOGLU, Heribert HELLSTERN, Bernard RISS, Christian SPRECHER
  • Somatostatin analogues
    Patent number: 9035021
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: May 19, 2015
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 8987413
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: March 24, 2015
    Assignee: Novartis AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Bernard Riss, Christian Sprecher
  • Somatostatin analogues
    Patent number: 8822637
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: September 2, 2014
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Solution Phase Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
    Publication number: 20140100355
    Abstract: The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: October 4, 2013
    Publication date: April 10, 2014
    Applicant: NOVARTIS AG
    Inventors: Murat ACEMOGLU, Heribert HELLSTERN, Felix KOLLMER, Robert SCHREIBER, Hans STETTLER
  • ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES
    Publication number: 20140100353
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 10, 2014
    Applicant: NOVARTIS AG
    Inventors: Murat ACEMOGLU, Heribert HELLSTERN, Bernard RISS, Christian SPRECHER
  • Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
    Publication number: 20140080995
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 20, 2014
    Applicant: NOVARTIS AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, John Lopez, Robert Schreiber, Christian Sprecher, Hans Stettler
  • Processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 8614289
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: December 24, 2013
    Assignee: Novartis AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, John Lopez, Robert Schreiber, Christian Sprecher, Hans Stettler
  • Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
    Publication number: 20120277406
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Application
    Filed: April 18, 2012
    Publication date: November 1, 2012
    Applicant: NOVARTIS AG
    Inventors: Murat ACEMOGLU, Heribert HELLSTERN, Felix KOLLMER, John LOPEZ, Robert SCHREIBER, Christian SPRECHER, Hans STETTLER
  • SOMATOSTATIN ANALOGUES
    Publication number: 20110172157
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 14, 2011
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • SOMATOSTATIN ANALOGUES
    Publication number: 20110166320
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Somatostatin analogues
    Patent number: 7939625
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: May 10, 2011
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Preparation of somatostatin peptides
    Patent number: 7615609
    Abstract: Provided is a process for preparing cyclic somatostatin analogues and the linear intermediates used in this process.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: November 10, 2009
    Assignee: Novartis AG
    Inventors: Heribert Hellstern, Werner Pachinger, Walter Prikoszovich, Bernhard Wietfeld
  • SOMATOSTATIN ANALOGUES
    Publication number: 20090069225
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: November 5, 2008
    Publication date: March 12, 2009
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Somatostatin analogues
    Patent number: 7473761
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: January 6, 2009
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Bacterial toxin neutralizer
    Patent number: 5260280
    Abstract: Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: November 9, 1993
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Hiroko Isoda, Yoshihiro Kawasaki, Morimasa Tanimoto, Shunichi Dosako, Tadashi Idota