Patents by Inventor Heribert Offermanns
Heribert Offermanns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7812312Abstract: The invention relates to an infrared measuring device, especially for the spectrometry of aqueous systems. Said device comprises at least one measuring unit, especially a measuring cell, also comprising at least one ATR-body and at least one infrared light source. The measuring unit contains at least one ATR-body which comprises at least two planar, substantially parallel limiting surfaces and which is transparent with respect to measuring radiation and which has an index of refraction which is greater than that of the medium which is arranged next to at least one limiting surface and which is to be examined, especially larger or equal to 1.5. The IR-measuring radiation on at least one of the planar, parallel limiting surfaces of the ATR-body can be totally reflected in an attenuated manner by at least six times.Type: GrantFiled: April 3, 2003Date of Patent: October 12, 2010Assignee: Johann Wolfgang Goethe-UniversitaetInventors: Werner Mäntele, Oliver Klein, Christian Zscherp, Andreas Barth, Hermann Von Lillienfeld-Toal, Hellmuth Von Prollius, Frithjof von Germar, Heribert Offermanns
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Publication number: 20060043301Abstract: The invention relates to an infrared measuring device, especially for the spectrometry of aqueous systems. Said device comprises at least one measuring unit, especially a measuring cell, also comprising at least one ATR-body and at least one infrared light source. The measuring unit contains at least one ATR-body which comprises at least two planar, substantially parallel limiting surfaces and which is transparent with respect to measuring radiation and which has an index of refraction which is greater than that of the medium which is arranged next to at least one limiting surface and which is to be examined, especially larger or equal to 1.5. The IR-measuring radiation on at least one of the planar, parallel limiting surfaces of the ATR-body can be totally reflected in an attenuated manner by at least six times.Type: ApplicationFiled: April 3, 2003Publication date: March 2, 2006Inventors: Werner Mantele, Oliver Klein, Christian Zscherp, Andreas Barth, Hermann Lillienfeld-Toal, Hellmuth Prollius, Frithjof Germar, Heribert Offermanns
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Patent number: 4332940Abstract: 2,3-Cycloalkenopyridines of the formula ##STR1## are prepared by reacting a cycloalkanone or cycloalkenone of the formula ##STR2## with an oxo compound of the formula ##STR3## where Z is an aliphatic carbon chain which is unsubstituted or has hydrocarbon substituents and R.sub.1, R.sub.2 and R.sub.3 are hydrogen or lower alkyl groups and ammonia in the presence of a dehydrating and dehydrogenating catalyst at a temperature of about 250.degree. to 550.degree. C.Type: GrantFiled: September 6, 1977Date of Patent: June 1, 1982Assignee: Deutsche Gold -und Silber-Scheideanstalt Vormals RoesslerInventors: Helmut Beschke, Heinz Friedrich, Heribert Offermanns
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Patent number: 4228082Abstract: Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl group or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III)in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.Type: GrantFiled: July 9, 1979Date of Patent: October 14, 1980Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Axel Kleemann, Herbert Klenk, Heribert Offermanns, Paul Scherberich, Werner Schwarze
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Patent number: 4224226Abstract: Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl groups or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III)in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.Type: GrantFiled: July 20, 1978Date of Patent: September 23, 1980Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Axel Kleemann, Herbert Klenk, Heribert Offermanns, Paul Scherberich, Werner Schwarze
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Patent number: 4209461Abstract: The process described in Klenk U.S. Pat. No. 4,113,773 is improved by employing alkali metal cyanide in which at least half of the alkali metal cyanide has a particle size below 0.4 mm and the remainder has a particle size below 1.0 mm.Type: GrantFiled: December 1, 1978Date of Patent: June 24, 1980Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Herbert Klenk, Theodor Lussling, Alfred Maierhofer, Heribert Offermanns, Hans Wagner
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Patent number: 4175195Abstract: Pyridines substituted in the 2-position by an aromatic or heteroaromatic group are prepared by reacting an aliphatic aromatic or aliphatic heteroaromatic ketone with an aliphatic oxo compound having a carbon to carbon ethylenic double bond on the carbon atom adjacent to the oxo group and ammonia in the presence of a dehydrating and dehydrogenating catalyst at a temperature of about 250.degree. to 550.degree. C.Type: GrantFiled: September 6, 1977Date of Patent: November 20, 1979Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Helmut Beschke, Heinz Friedrich, Heribert Offermanns
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Patent number: 4144340Abstract: There are prepared compounds corresponding to the general formulaT -- Alk -- NH -- CH.sub.2 -- CH(OH) -- CH.sub.Type: GrantFiled: April 12, 1977Date of Patent: March 13, 1979Assignee: Deutsche Gold und Silber- Scheideanstalt vormals RoesslerInventors: Heribert Offermanns, Karl H. Klingler, Klaus Thiemer, Fritz Stroman
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Patent number: 4144269Abstract: Benzoyl cyanide is made from benzoyl chloride and an alkali metal cyanide in a two phase system comprising water and an inert organic solvent which has only slight miscibility with water in the presence of a tertiary amine and hydrogen cyanide.Type: GrantFiled: June 2, 1977Date of Patent: March 13, 1979Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Herbert Klenk, Theodor Lussling, Alfred Maierhofer, Heribert Offermanns, Hans Wagner
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Patent number: 4124630Abstract: Chloromethyl thiocyanate is prepared by reacting bromochloromethane with an alkali or alkaline earth thiocyanate or with ammonium thiocyanate in the presence of water and an onium salt as a catalyst.Type: GrantFiled: October 26, 1977Date of Patent: November 7, 1978Inventors: Heribert Offermanns, Werner Schwarze, Rudolf Vanheertum
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Patent number: 4122116Abstract: There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atoms alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms.Type: GrantFiled: February 23, 1978Date of Patent: October 24, 1978Assignee: Deutsche Gold- und Silber- Scheideanstalt vormals RoesslerInventors: Herbert Klenk, Heribert Offermanns, Werner Schwarze
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Patent number: 4117008Abstract: Benzoyl cyanide is made by reacting benzoic anhydride with an alkali cyanide in an inert organic solvent.Type: GrantFiled: June 2, 1977Date of Patent: September 26, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoessierInventors: Herbert Klenk, Heribert Offermanns
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Patent number: 4113773Abstract: Benzoyl cyanide is made by reacting benzoyl chloride with an alkali cyanide in the presence of a carboxylic acid nitrile and a copper (I) salt at a temperature of about 50.degree. to 160.degree. C.Type: GrantFiled: June 20, 1977Date of Patent: September 12, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt Vormals RoesslerInventors: Herbert Klenk, Theodor Lussling, Alfred Maierhofer, Heribert Offermanns, Hans Wagner
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Patent number: 4108875Abstract: There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atom alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl, wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms.Type: GrantFiled: June 2, 1977Date of Patent: August 22, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt Vormals RoesslerInventors: Herbert Klenk, Heribert Offermanns, Werner Schwarze
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Patent number: 4108877Abstract: There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atom alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl, wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms.Type: GrantFiled: June 2, 1977Date of Patent: August 22, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt Vormals RoesslerInventors: Herbert Klenk, Heribert Offermanns, Werner Schwarze
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Patent number: 4073945Abstract: The calcium salts of mono-hydroxymethyl lysine and bis(hydroxymethyl) lysine are prepared by reacting lysine and formaldehyde in water containing calcium ions at a pH of at least 8 and at most 12.5. The compounds are useful as fodder for ruminants.Type: GrantFiled: May 18, 1976Date of Patent: February 14, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Heidrun Bertram, Rudolf Fahnenstich, Heribert Offermanns, Herbert Tanner
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Patent number: 4073792Abstract: Compounds are prepared having the formula: ##STR1## where R.sub.1 is alkyl of 1 to 6 carbon atoms or phenyl and R.sub.2 is hydrogen or halogen and tautomeric form and pharmacologically acceptable salts thereof. The compounds have sedative, psychosedative, anxiolytic and spasmolytic properties and in some cases antiphlogistic properties.Type: GrantFiled: April 9, 1974Date of Patent: February 14, 1978Assignee: Deutsche Gold- und Silber-Scheideanstalt Vormals RoesslerInventors: Walter vonBebenburg, Heribert Offermanns
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Patent number: 4061674Abstract: Penicillamine or a homolog thereof is obtained by reacting a 2-disubstituted-5,5-alkyl-thiazolidine nitrile, alkyl having 1 to 6 carbon atoms, with a mineral acid in a two-stage proceeding wherein in the first stage relatively low temperatures and a relatively high concentration of the mineral acid are employed while in the second stage the concentration of the acid is relatively low and the temperatures are relatively high, the term "relatively" referring to the relationship of said two stages of the reaction with mineral acid.Type: GrantFiled: February 12, 1976Date of Patent: December 6, 1977Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Friedrich Asinger, Wolf-Dieter Pfeifer, Heribert Offermanns, Paul Scherberich, Gerd Schreyer
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Patent number: 4060548Abstract: Penicillamine and its hydrochloride are made by reacting i-butyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-.DELTA..sup.3, then reacting the latter compound with substantially anhydrous hydrogen cyanide so as to form the corresponding thiazolidine 4-carbonitrile, thereupon treating the latter compound with an excess of concentrated hydrochloric acid at an elevated temperature and separating the components of the mixture formed and recovering the penicillamine hydrochloride which may then be converted to the free D,L-penicillamine.Type: GrantFiled: December 19, 1975Date of Patent: November 29, 1977Assignee: Deutsche Gold- und Silber-Scheideanstalt Vormals RoesslerInventors: Friedrich Asinger, Heribert Offermanns, Miklos Ghyczy
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Patent number: RE31071Abstract: There are produced 6-aza-3H-1,4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula ##STR1## where R.sub.1 is a halogen, R.sub.2 and R.sub.3 are hydrogen, halogen, trifluoromethyl, nitro, nitrile, hydroxy, lower alkyl, lower alkoxy, R.sub.4 is hydrogen, hydroxyl, hydroxyl acylated with a mono or dicarboxylic aid of 2 to 6 carbon atoms, lower alkoxy, lower alkyl, benzyl, lower aliphatic acyl, carboxy or carb-lower alkoxy, Z is nitrogen or NO, R.sub.5 is hydrogen, lower alkyl, lower alkyl substituted with cycloalkyl of 3 to 6 carbon atoms, lower alkenyl, cycloalkyl of 3 to 6 carbon atoms, lower hydroxyalkyl, benzyl, aliphatic acyl of 2 to 6 carbon atoms aminoalkyl of 2 to 7 carbon atoms, mono or di lower alkyl substituted aminoalkyl of 2 to 7 carbon atoms, lower alkyl substituted with 5 to 7 membered N-heterocyclic ring, containing 0 to 1 additional nitrogen or oxygen atoms, and A is oxygen, sulfur, .dbd.NR.sub.5, .dbd.NOR.sub.5, .dbd.NH--NHR.sub.5 or two hydrogen atoms and the --N(R.Type: GrantFiled: September 1, 1981Date of Patent: November 2, 1982Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals RoesslerInventors: Walter von Bebenburg, Heribert Offermanns