Abstract: A low-dose estradiol cream for vaginal administration that is safe and clinically effective to treat symptoms of menopause and a kit comprising the low-dose estradiol cream and an applicator are provided. A method of treatment of the symptoms of vulvar and/or vaginal atrophy associated with menopause, that includes the step of vaginally administering the low-dose estradiol cream to a woman in need thereof is also provided.

Abstract: A multiphasic method of contraception comprising the steps of sequentially administering to a female of child bearing age a Phase I composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg norethindrone acetate and an estrogen in an amount equivalent to about 5 to about 15 mcg of ethinyl estradiol for about 7 to about 14 days; a Phase II composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 10 to about 25 mcg of ethinyl estradiol for about 14 to about 22 days; a Phase III composition containing a progestogen in an amount equivalent to about 0.3 to about 1.

Abstract: The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention.

Abstract: A multiphasic method of contraception comprising the steps of sequentially administering to a female of child bearing age a Phase I composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg norethindrone acetate and an estrogen in an amount equivalent to about 5 to about 15 mcg of ethinyl estradiol for about 7 to about 14 days; a Phase II composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 10 to about 25 mcg of ethinyl estradiol for about 14 to about 22 days; a Phase III composition containing a progestogen in an amount equivalent to about 0.3 to about 1.

Abstract: The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention.

Abstract: The present invention is a method of non-continuous administration of a pharmaceutical to a female for a condition associated with the female's menstrual cycle, comprising administering a daily placebo dosage, starting on the first or the second day of the menstrual cycle and continuing the daily administration for a placebo dosage period. Next administering a daily pharmaceutical dosage, starting on the day after the last daily placebo dosage was administered and continuing the daily administration of the pharmaceutical dosage for a pharmaceutical dosage period. Both the placebo dosages and the pharmaceutical dosages are contained in a single package.

Abstract: The present invention is a method of non-continuous administration of a pharmaceutical to a female for a condition associated with the female's menstrual cycle, comprising ascertaining a number of days in the female's menstrual cycle, and then administering a daily first dosage, starting on the first or the second day of the menstrual cycle and continuing the daily administration for a first dosage period. Next administering a daily second dosage, starting on the day after the last daily first dosage was administered and continuing the daily administration of the second dosage for a second dosage period. Wherein either the first dosage is a placebo and the second dosage is the pharmaceutical, or the first dosage is the pharmaceutical and the second dosage is a placebo. Both the first dosages and the second dosages being contained in a single package.

Abstract: The present invention provides methods for treating physical conditions resulting from postmenopausel estrogen decline in a postmenopausel subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit for carrying out the methods of the present invention.

Abstract: The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention.