Patents by Inventor Herman Groen

Herman Groen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies against and uses therof
    Patent number: 9944694
    Abstract: The invention relates to the field of immunology and vaccine development. In particular, it relates to antibodies and fragments thereof against Staphylococcus aureus and to therapeutic and diagnostic uses thereof. Provided is an isolated antibody or a functional fragment thereof, which binds to an epitope of the Immunodominant Staphylococcal antigen A (IsaA), wherein said antibody comprises at least four Isa A epitope-binding CDR sequences selected from the group consisting of SEQ ID NO: 1; SEQ ID NO: 2; SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5; SEQ ID NO: 6, and functional equivalents thereof having an amino acid sequence that is at least 85% identical to an amino acid sequence of SEQ ID NO: 1-6.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: April 17, 2018
    Assignees: Rijksuniversiteit Groningen, Academisch Ziekenhuis Groningen
    Inventors: Jan Maarten Van Dijl, Girbe Buist, Hendrik Petrus Jozef Bonarius, Neeltje Margaretha Kooi, Goffe Sytse Elsinga, Herman Groen
  • ANTIBODIES AGAINST STAPHYLOCOCCUS AUREUS AND USES THEROF
    Publication number: 20170002063
    Abstract: The invention relates to the field of immunology and vaccine development. In particular, it relates to antibodies and fragments thereof against Staphylococcus aureus and to therapeutic and diagnostic uses thereof. Provided is an isolated antibody or a functional fragment thereof, which binds to an epitope of the Immunodominant Staphylococcal antigen A (IsaA), wherein said antibody comprises at least four Isa A epitope-binding CDR sequences selected from the group consisting of SEQ ID NO: 1; SEQ ID NO: 2; SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5; SEQ ID NO: 6, and functional equivalents thereof having an amino acid sequence that is at least 85% identical to an amino acid sequence of SEQ ID NO: 1-6.
    Type: Application
    Filed: December 12, 2014
    Publication date: January 5, 2017
    Inventors: Jan Maarten VAN DIJL, Girbe BUIST, Hendrik Petrus Jozef BONARIUS, Neeltje Margaretha KOOI, Goffe Sytse ELSINGA, Herman GROEN
  • Compositions And Methods Of Modulating The Immune Response
    Publication number: 20150216974
    Abstract: The present invention provides methods and compositions of enhancing the immune response to an antigen.
    Type: Application
    Filed: September 15, 2014
    Publication date: August 6, 2015
    Inventors: Herman Groen, A1 Mateczun, Gail Chapman, Les Baillie, Stanley Goldman, Mark Albrecht
  • Combination Antibodies For The Treatment And Prevention Of Disease Caused By Bacillus Anthracis And Related Bacteria And Their Toxins
    Publication number: 20110129460
    Abstract: The invention relates to methods and compositions for the prevention and treatment of disease caused by B. anthracis or a bacterium which produces toxins or toxin components homologous to the virulence factors produced by B. anthracis or to the toxins or toxin components themselves, in the absence of bacteria. The methods and compositions of the invention comprise a combination of at least two antibodies, preferably monoclonal antibodies, most preferably human monoclonal antibodies, each of which binds with high affinity to a different epitope of one or more bacterial antigens.
    Type: Application
    Filed: July 21, 2010
    Publication date: June 2, 2011
    Applicant: IQ Therapeutics B.V.
    Inventor: Herman Groen
  • Methods of inducing IL-10 production
    Patent number: 7919097
    Abstract: The invention provides a method of inducing IL-10 production.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: April 5, 2011
    Assignee: IQ Corporation BV
    Inventors: Herman Groen, Sibrand Poppema, Anke van den Berg, Lydia Visser, Judith van der Leij, Rob P. van Weeghel, Peter Zwiers
  • Human Anthrax Toxin Neutralizing Monoclonal Antibodies and Methods of Use Thereof
    Publication number: 20110059098
    Abstract: The invention fully humanized monoclonal antibodies that neutralize Bacillus anthracis. Also provided are methods of treating or preventing a Bacillus anthracis infection. The invention also provides methods of passive vaccination of a subject against Bacillus anthracis.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 10, 2011
    Applicant: IQ Therapeutics BV
    Inventors: Herman Groen, Christine Cool-Kebbedies, Kunja S. Slopsema, Hans Westra
  • Methods of producing stable B-lymphocytes
    Patent number: 7807415
    Abstract: The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: October 5, 2010
    Assignee: IQ Therapeutics BV
    Inventors: Herman Groen, Hans H. Westra
  • Methods of inducing IL-10 production
    Patent number: 7700105
    Abstract: The invention provides a method of inducing IL-10 production.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: April 20, 2010
    Assignee: IQ Corporation BV
    Inventors: Herman Groen, Sibrand Poppema, Anke ven den Berg, Lydia Visser, Judith van der Leij, Rob P. van Weeghel, Peter Zwiers
  • METHODS OF INDUCING IL-10 PRODUCTION
    Publication number: 20100040639
    Abstract: The invention provides a method of inducing IL-10 production.
    Type: Application
    Filed: October 15, 2009
    Publication date: February 18, 2010
    Applicant: IQ CORPORATION BV
    Inventors: Herman Groen, Sibrand Poppema, Anke van den Berg, Lydia Visser, Judith van der Leij, Rob P. van Weeghel, Peter Zwiers
  • Human anthrax toxin neutralizing monoclonal antibodies and methods of use thereof
    Patent number: 7658925
    Abstract: The invention fully humanized monoclonal antibodies that neutralize Bacillus anthracis. Also provided are methods of treating or preventing a Bacillus anthracis infection. The invention also provides methods of passive vaccination of a subject against Bacillus anthracis.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: February 9, 2010
    Assignee: IQ Therapeutics BV
    Inventors: Herman Groen, Christine Cool-Kebbedies, Kunja S. Slopsema, Hans Westra
  • Methods of inducing IL-10 production
    Publication number: 20080019987
    Abstract: The invention provides a method of inducing IL-10 production
    Type: Application
    Filed: January 8, 2007
    Publication date: January 24, 2008
    Inventors: Herman Groen, Sibrand Poppema, Anke Berg, Lydia Visser, Judith Leij, Rob Weeghel, Peter Zwiers
  • Compositions and Methods Of Modulating the Immune Response
    Publication number: 20070202117
    Abstract: The present invention provides methods and compositions of enhancing the immune response to an antigen.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 30, 2007
    Inventors: Herman Groen, Al Mateczun, Gail Chapman, Les Baillie, Stanley Goldman, Mark Albrecht
  • Methods of producing stable B-lymphocytes
    Publication number: 20070098711
    Abstract: The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.
    Type: Application
    Filed: August 23, 2006
    Publication date: May 3, 2007
    Inventors: Herman Groen, Hans Westra
  • Methods of producing stable B-lymphocytes
    Publication number: 20070065919
    Abstract: The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.
    Type: Application
    Filed: August 23, 2006
    Publication date: March 22, 2007
    Inventors: Herman Groen, Hans Westra
  • Methods of inducing IL-10 production
    Patent number: 7160861
    Abstract: The invention provides a method of inducing IL-10 production.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: January 9, 2007
    Assignee: IQ Corporation BV
    Inventors: Herman Groen, Sibrand Poppema, Anke van den Berg, Lydia Visser, Judith van der Leij, Rob P. van Weeghel, Peter Zwiers
  • Human anthrax toxin neutralizing monoclonal antibodies and methods of use thereof
    Publication number: 20060258842
    Abstract: The invention fully humanized monoclonal antibodies that neutralize Bacillus anthracis. Also provided are methods of treating or preventing a Bacillus anthracis infection. The invention also provides methods of passive vaccination of a subject against Bacillus anthracis.
    Type: Application
    Filed: March 3, 2005
    Publication date: November 16, 2006
    Inventors: Herman Groen, Christine Cool-Kebbedies, Kunja Slopsema, Hans Westra
  • Methods of inducing IL-10 production
    Publication number: 20050215465
    Abstract: The invention provides a method of inducing IL-10 production
    Type: Application
    Filed: December 13, 2004
    Publication date: September 29, 2005
    Inventors: Herman Groen, Sibrand Poppema, Anke Berg, Lydia Visser, Judith Leij, Rob Weeghel, Peter Zwiers