Patents by Inventor Herman H. Grootveld

Herman H. Grootveld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cephem derivatives
    Patent number: 5359058
    Abstract: A cephalosporin compound substituted in the 7-position with a (cyclo)alkylideneammonio group of formula (II) ##STR1## wherein X' is an anion from an acid HX, R.sub.1 and R.sub.2 are individually a C.sub.1 -C.sub.16 alkyl group, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkylidene ring with up to 8 carbon atoms and a process for the preparation which compounds are useful intermediates.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: October 25, 1994
    Assignee: Gist-Brocades, N.V.
    Inventors: Jan Verweij, Henri G. J. Hirs, Hendrik A. Witkamp, Everardus J. A. M. Leenderts, Jan J. Dekoning, Herman H. Grootveld
  • Cephalosporin derivatives
    Patent number: 5164494
    Abstract: Process for the preparation of 7.beta.-amino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives, new intermediates comprising 7.beta.-(cyclo)alkylideneammonio-3-halomethyl-3-cephem-4-carbox ylic acid derivatives and 7.beta.-amino/ammonio-3-bromomethyl-3-cephem-4-carboxylic acid derivatives and the processes for the preparation of these intermediates.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: November 17, 1992
    Assignee: Gist-Brocades N.V.
    Inventors: Hendrik A. Witkamp, Jan J. DeKoning, Jan Verwej, Herman H. Grootveld, Everardus J. A. M. Leenderts
  • Process for the preparation of cephem compounds
    Patent number: 4921954
    Abstract: Process for the preparation of 7.beta.-amino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives, new intermediates comprising 7.beta.-(cyclo)alkylideneammonio-3-halomethyl-3-cephem-4-carbox ylic acid derivatives and 7.beta.-amino/ammonio-3-bromomethyl-3-cephem-4-carboxylic acid derivatives and the processes for the preparation of these intermediates.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: May 1, 1990
    Assignee: Gist-Brocades N.V.
    Inventors: Hendrik A. Witkamp, Jan Verweij, Jan J. DeKoning, Herman H. Grootveld, Everardus J. A. M. Leenderts
  • Cephalosporin deoxygenation process
    Patent number: 4695627
    Abstract: A process for the preparation of 7.beta.-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70.degree. C. to 0.degree. C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.
    Type: Grant
    Filed: September 21, 1984
    Date of Patent: September 22, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Jan Verweij, Herman H. Grootveld, Henri G. J. Hirs, Gerardus J. Van Veen, Jan Kalter, Peter W. Henniger
  • Sodium amoxicillin solvate
    Patent number: 4318852
    Abstract: The solvate of sodium amoxicillin and N-methyl-2-pyrrolidone and its preparation which is a stable antibiotic from which injectable solutions may be prepared.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: March 9, 1982
    Assignee: Gist-Brocades N.V.
    Inventors: Herwarth Heitman, Johannes K. van der Drift, Everardus J. A. M. Leenderts, Herman H. Grootveld