Patents by Inventor Herman Hal Stein

Herman Hal Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
    Patent number: 4081447
    Abstract: A group of .beta.-blockers represented by the formula ##STR1## wherein R is ##STR2## or ##STR3## and the physiologically compatible acid addition salts thereof. These .beta.-blockers are .beta.-adrenergic receptor blocking agents which are useful in the treatment of angina pectoris, heart arrhythmia, and high blood pressure.
    Type: Grant
    Filed: April 9, 1975
    Date of Patent: March 28, 1978
    Assignee: Abbott Laboratories
    Inventors: Raj Nandan Prasad, Herman Hal Stein, Karin Rosemarie Tietje
  • Adenosine-5'-carboxylic acid amides
    Patent number: 4029884
    Abstract: Adenosine-5'-carboxylic acid amides represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, loweralkyl, lowerhaloalkyl, lowerhydroxyalkyl, lowercycloalkyl, loweralkylcycloalkyl, loweralkenyl, lowerhaloalkenyl, lowerhydroxyalkenyl, loweralkynyl, lowerhaloalkynyl, benzylamino, phenyl, loweralkylphenyl, loweralkoxyloweralkyl, substituted phenyl, 2-methylfuran or di(C.sub.1 -C.sub.4)alkylamino(C.sub.1 -C.sub.4)alkyl, adamantyl or R.sub.1 and R.sub.2 taken together form a 5 or 6 membered heterocyclic moiety; R.sub.3 and R.sub.4 are hydrogen or acyl, or taken together form an isopropylidene or a benzylidene group; or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: March 22, 1972
    Date of Patent: June 14, 1977
    Assignee: Abbott Laboratories
    Inventors: Herman Hal Stein, Raj Nandan Prasad
  • 2-Substituted adenosine-5'-carboxylates in the treatment of anginal pain
    Patent number: 3992531
    Abstract: 2-Substituted adenosine-5'-carboxylates represented by the formula ##SPC1##Wherein R is amino, acetamido or hydroxy, R.sub.1 is loweralkyl, haloloweralkyl, hydroxyloweralkyl, lowercycloalkyl, loweralkenyl, loweralkynyl, loweralkyl(C.sub.3 -C.sub.6)cycloalkyl or alkoxyalkyl and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub.3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof. The compounds wherein R.sub.2 and R.sub.3 are hydrogen or acyl are useful in treating cardiovascular disorders and are particularly useful as anti-anginal agents. Compounds wherein R.sub.2 and R.sub.3 when taken together form an isopropylidene or benzylidene moiety are intermediates useful in making the final products.
    Type: Grant
    Filed: September 13, 1974
    Date of Patent: November 16, 1976
    Assignee: Abbott Laboratories
    Inventors: Raj Nandan Prasad, Herman Hal Stein, Karin Rosemarie Tietje
  • Platelet aggregation inhibitors
    Patent number: 3966917
    Abstract: Adenosine-5'-carboxamides which are effective as platelet aggregation inhibitors and represented by the formula ##SPC1##Wherein R is hydrogen, loweralkyl, lowercycloalkyl, loweralkenyl, or lowerhydroxyalkyl.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: June 29, 1976
    Assignee: Abbott Laboratories
    Inventors: Raj Nandan Prasad, Herman Hal Stein