Patents by Inventor Herman Kempen

Herman Kempen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of condensed triazepine derivatives and their use as BET inhibitors
    Patent number: 11708374
    Abstract: The invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of inflammatory diseases, fibtrotic diseases and neoplastic diseases.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: July 25, 2023
    Assignee: WORG PHARMACEUTICALS (ZHEJIANG) CO., LTD.
    Inventors: Herman Kempen, Adel Far
  • PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS
    Publication number: 20210101909
    Abstract: The invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of inflammatory diseases, fibtrotic diseases and neoplastic diseases.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 8, 2021
    Inventors: Herman KEMPEN, Adel FAR
  • Preparation of condensed triazepine derivatives and their use as BET inhibitors
    Patent number: 10906917
    Abstract: The invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of inflammatory diseases, fibtrotic diseases and neoplastic diseases.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 2, 2021
    Assignee: DYBLY AG
    Inventors: Herman Kempen, Adel Far
  • PREPARATION OF CONDENSED TRIAZEPINE DERIVATIVES AND THEIR USE AS BET INHIBITORS
    Publication number: 20200231598
    Abstract: The invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of inflammatory diseases, fibtrotic diseases and neoplastic diseases.
    Type: Application
    Filed: March 6, 2020
    Publication date: July 23, 2020
    Inventors: Herman KEMPEN, Adel FAR
  • Thienotriazolodiazepine derivatives active on apo A
    Patent number: 8569288
    Abstract: The invention relates to new thienotriazolodiazepine derivatives of the formula (1) wherein R1 is CH3, R2 is CH3 or —(CH2)n—R4 or —(CH2)n—O—R4 or —(CH2)n—S—R4 wherein n is 1, 2, 3 or 4 and R4 is CH3, CH2CH3 or CH2CH2OCH3, and R3 is hydrogen or —OCH2O— or —OCH2CH2O— connected to the ortho/meta position or meta/para position of the phenyl ring; or wherein R1 and R2 are hydrogen and R3 is —OCH2O— Or —OCH2CH2O— connected to the ortho/meta position or meta/para position of the phenyl ring; and pharmaceutically acceptable acid addition salts thereof. These compounds and pharmaceutical compositions containing them are useful in the treatment and prevention of atherosclerotic artery diseases, such as myocardial infarction and stroke, and of Alzheimer's disease.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 29, 2013
    Assignee: CircoMed LLC
    Inventors: Herman Kempen, Daniel Bellus, Barbara Staehelin
  • THIENOTRIAZOLODIAZEPINE DERIVATIVES ACTIVE ON APO A
    Publication number: 20110230460
    Abstract: The invention relates to new thienotriazolodiazepine derivatives of the formula (1) wherein R1 is CH3, R2 is CH3 or —(CH2)n—R4 or —(CH2)n—O—R4 or —(CH2)n—S—R4 wherein n is 1, 2, 3 or 4 and R4 is CH3, CH2CH3 or CH2CH2OCH3, and R3 is hydrogen or —OCH2O— or —OCH2CH2O— connected to the ortho/meta position or meta/para position of the phenyl ring; or wherein R1 and R2 are hydrogen and R3 is —OCH2O— Or —OCH2CH2O— connected to the ortho/meta position or meta/para position of the phenyl ring; and pharmaceutically acceptable acid addition salts thereof. These compounds and pharmaceutical compositions containing them are useful in the treatment and prevention of atherosclerotic artery diseases, such as myocardial infarction and stroke, and of Alzheimer's disease.
    Type: Application
    Filed: October 29, 2009
    Publication date: September 22, 2011
    Applicant: CircoMed LLC
    Inventors: Herman Kempen, Daniel Bellus, Barbara Staehelin
  • Use of a thienotriazolodiazephine to increase apolipoprotein A-I levels
    Patent number: 5854238
    Abstract: 9-methyl-4-phenyl-6H-thieno?3,2-f!-s-triazolo?4,3-a!?1,4!diazepine for the treatment and prevention of illnesses which are caused by low plasma apolipoprotein A-I levels as coronary coronary disease.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: December 29, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Herman Kempen