Abstract: An improved reservoir is provided for use in a medication infusion device for operating the reservoir to administer a fluid to a patient. The reservoir comprises a hollow barrel adapted to receive a supply of fluid for delivery through infusion tubing or the like to the patient, in combination with a reservoir plunger. The reservoir plunger is designed to engage a motor-driven lead screw of the medication infusion device. The reservoir plunger has an integral split nut connector formed on the end of the plunger, which is in co-axial alignment with the lead screw whereby the split nut connector can be engaged directly to the lead screw.

Abstract: An improved reservoir is provided for use in a medication infusion device for operating the reservoir to administer a fluid to a patient. The reservoir comprises a hollow barrel adapted to receive a supply of fluid for delivery through infusion tubing or the like to the patient, in combination with a reservoir plunger. The reservoir plunger is designed to engage a motor-driven lead screw of the medication infusion device.

Abstract: In an ICD, a highly efficient biphasic defibrillation pulse is generated by switching at least two charged capacitors, e.g., three capacitors, from a parallel connection to various combinations of a parallel/series connection or a series connection during the first phase of the defibrillation pulse. Such mid-stream parallel/series connection changes of the capacitors steps up the voltage applied to the cardiac tissue during the first phase. A stepped-up voltage during the first phase, in turn, gives an extra boost to, and thereby forces additional charge (current) into, the cardiac tissue cells, and thereby transfers more charge to the membrane of the excitable cardiac cell than if the capacitors were continuously discharged in series. Phase reversal is timed with the cell membrane reaching its maximum value at the end of the first phase.

Abstract: An implantable blood flow sensor for measuring a blood flow rate through a blood vessel within a person's body. The flow sensor includes a rigid cylindrical tube, sized to fit within the blood vessel, a heater attached to the tube, and a pyroelectric detector located within the tube. A predetermined amount of heat energy is produced by the heater and the pyroelectric detector monitors the resultant temperature change and generates a temperature signal based on the temperature change. A processor generates a data signal, based on the temperature change, that indicates the blood flow rate through the blood vessel or artery. The rigid tube protects the pyroelectric detector from external forces that may produce unwanted signals due to piezoelectric effects. Additionally, the heater may be incorporated into one of the electrodes of the pyroelectric detector as a serpentine path in the electrode that forms a resistive heating element.

Abstract: A two-conductor bus system is provided to electrically interconnect a plurality of physiologic sensors to a pacemaker, each sensor being adapted for placement along a pacing lead. The conductors of the bus extend longitudinally through the insulating material of the lead, connecting to each sensor. The pacemaker provides a supply voltage on the bus to provide power to the sensors. The sensors modulate the supply voltage on the bus to transmit information to the pacemaker. This information may be used by the pacemaker to adaptively pace the heart. In one embodiment, the sensors include bus monitoring circuitry for receiving control signals from the pacemaker.

Abstract: A flow sensor adapted for placement along a pacing lead or other catheter comprises a thermopile formed on the outer surface of a tubular substrate. The thermopile comprises a plurality of interconnected conductors of an alternating metal type. Junctions between conductors of the thermopile are alternately located near the longitudinal ends of the flow sensor, so that a voltage generated by the thermopile indicates the difference in temperature between the ends of the flow sensor. To measure blood flow with the flow sensor, an alternating current is induced through the thermopile to heat the flow sensor in a generally symmetrical manner. A voltage generated by the thermopile is then measured to obtain a sample of the magnitude and direction of the velocity of blood flow.

Abstract: An implantable medical device including a piezoelectric accelerometer activity sensor. The activity sensor includes a thin film piezoelectric cell within a frame structure. A mass imposes a load based upon acceleration to apply lateral or transverse forces which cause the generation of an electrical potential within the piezoelectric cell, which can be used by a rate control algorithm within the device to control operation of the device.

Abstract: A fluid flow rate measuring apparatus having a thermistor exposed to a flow of fluid and a driver circuit operable in an initial constant-voltage mode, in which it applies a substantially constant voltage across the thermistor, and a subsequent constant-current mode, in which it applies a substantially constant current through the thermistor, such current corresponding to the current level at the end of the constant-voltage mode. A voltage sensor measures the resultant voltage drop across the thermistor, which is a direct measurement of the fluid flow rate and which is substantially insensitive to variations in ambient temperature.

Abstract: A power converter apparatus adapted for use in a defibrillating cardiac pacemaker, to selectively provide a prescribed high voltage useful in treating a cardiac fibrillation. A pulse generator-cyclically applies a relatively low battery voltage V.sub.s to a step-up transformer, to controllably charge a high-voltage capacitor. The time durations of the cyclic applications of the battery voltage V.sub.s are controlled by digital feedback of several parameters, including peak transformer current, average transformer current., battery voltage V.sub.s, and the voltage on the high-voltage capacitor. If any of the measured parameters is determined to be outside a predetermined limit, the pulsing of the transformer is incrementally modified. A smooth, efficient charging of the high-voltage capacitor thereby is provided.

Abstract: A drive circuit for use with a capacitive load includes two transistors controlled by a drive voltage and connected to the load through an inductor. A supply voltage is alternately connected and disconnected to the circuit to achieve a resonant transfer of energy from the supply voltage. Energy stored in the load is transferred to the inductor and then back to the load, thereby reversing and augmenting the output voltage across the load and providing an instantaneous output voltage many times the supply voltage. Diodes ensure that the current flows in the proper polarity through the transistors.

Abstract: A drive circuit for applying a supply voltage to a sending coil provides resonant coupling of the sending coil with the target coil regardless of changes in the inductance of the sending coil, as long as the resonant frequency of the sending coil is greater than the resonant frequency of the target coil. A controller provides variable delay intervals in the application of the supply voltage, thereby compensating for changes in the sending coil's inductance with the passage of time and proximity effects. The controller examines the reflected voltage induced in the sending coil by changing currents in the target coil to examine the degree of resonant coupling between the two coils and correct any mistuning.

Abstract: An air-in-line detection system for use in detecting air bubbles in the fluid line of a disposable cassette mounted on a main pump unit is disclosed which can accurately detect air bubbles in any type of fluid, whether clear or opaque. The system uses an optical module mounted on the main pump unit to supply light and to detect light returned from the cassette, and an optical viewing area in the fluid flow path near the outlet end of the cassette. An inverted prism in the optical viewing path reflects light back to the optical module when air is contained in the fluid flow path adjacent the optical viewing area, with the light not being returned if there are no air bubbles contained in the fluid flow path.

Abstract: A method and apparatus are disclosed for deriving digital signals from analog variations of different sensing elements in a transducer. Each sensing device controls the frequency of a variable frequency oscillator, which is energized when a reading is to be taken for that specific sensing device. The periodic signal is coupled to a first counter which counts a presettable total number of cycles so as to establish a variable time period proportioned to the value represented by the then existing state of the sensing device. Concurrently, a second counter is operated for a like time interval, but counts cycles from a fixed frequency clock source at a much higher frequency. The number of cycles counted by the second counter is proportional to the analog signal from the sensing device. This arrangement enables the analog signals from the sensing devices to be digitized in sequence with compact circuitry having low power drain.

Abstract: A power converter for use in converting a variable DC input voltage into a variable DC output voltage is disclosed which uses control circuitry on both the input and the output to optimize converter performance. By charging the inductor up nearly to the saturation point, but completely avoiding saturation of the inductor, power capability at the input end is maximized. By discharging the inductor completely without either losing power capability by continuing to attempt to discharge the inductor after the charge is depleted or by failing to nearly discharge the inductor thereby presenting the possibility of saturation to the boosting of current through the inductor during the next charge cycle.

Abstract: A method and apparatus are disclosed for deriving digital signals from analog variations of different sensing elements in a transducer. Each sensing device controls the frequency of a variable frequency oscillator, which is energized when a reading is to be taken for that specific sensing device. The periodic signal is coupled to a first counter which counts a presettable total number of cycles so as to establish a variable time period proportioned to the value represented by the then existing state of the sensing device. Concurrently, a second counter is operated for a like time interval, but counts cycles from a fixed frequency clock source at a much higher frequency. The number of cycles counted by the second counter is proportional to the analog signal from the sensing device. This arrangement enables the analog signals from the sensing devices to be digitized in sequence with compact circuitry having low power drain.

Abstract: A programmable cardiac tissue stimulator having a receiving coil and RF pulse width check/data separator (6) for receiving programming data, a communications State sequencer (8) for directing the sequence of command activities within the apparatus, command decode and address latch (12), memory (16, 18, 20, 22, 30, 40, 42) for storing the received programming data, pulse generator logic (24) for generating an output stimulation pulse according to a programmed stimulation scheme, a first timer (32), a second timer (34) and third timer (44) interactive with the pulse generator (24) and memory (16, 18, 20, 22, 30, 40, 42) for carrying out the timing functions of the pulse generator logic (24), a first sensor (46) for sensing electrical activity in the atrium, a second sensor (48) for sensing electrical activity in the ventricle, antitachycardia logic (50) for limiting the rate of natural stimulation of cardiac tissue, an output lead (54) to the atrium, an output lead (56) to the ventricle, and a control clock (28

Abstract: A system for measuring and for monitoring pulsed and steady state fluid flow through fluid flow paths includes a device for modifying the temperature of part of the flow path and a device for pyroelectrically detecting changes in temperature as fluid flows through the temperature-modified part of the flow path.