Abstract: The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

Abstract: The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

Abstract: The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

Abstract: The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

Abstract: A mixer stage is provided that mixes a differential input signal with a differential square-wave signal of an oscillator, having a first amplifier element and a second amplifier element, each of which amplifier elements has a first current connection, a second current connection, and a connection for the differential input signal, having four control elements and also a first output and a second output, wherein the four control elements are modulated in pairs by the differential square-wave signal, thereby connecting each second current connection alternately, and in each case individually, to one of the two outputs. The mixer stage has field-effect transistors as amplifier elements whose first current connections are connected to a constant reference voltage. In addition, a method for mixing frequencies that uses this mixer stage is also disclosed.

Abstract: A mixer stage is provided that includes an oscillator, a first input, a second input, a first output, a second output, a set of four controllable amplifier elements, and a first current source. The mixer stage further includes at least one second current source in addition to the first current source, the first current source and the at least one second current source can each be switched on and off by an associated switching input that is connected to an associated oscillator output. Pairs of amplifier elements of the set of four together with at least one of the at least two current sources in its switched-on state form a differential amplifier for an input signal present at the first input and the second input. A method for mixing frequencies is also provided.