Patents by Inventor Herman O. Sintim

Herman O. Sintim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of kinase networks and uses thereof
    Patent number: 11891391
    Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: February 6, 2024
    Assignee: Purdue Research Foundation
    Inventors: Herman O. Sintim, Neetu Dayal, Clement Opoku-Temeng
  • BENZAMIDE ANTIBACTERIAL AGENTS
    Publication number: 20230391767
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 7, 2023
    Inventors: Herman O. SINTIM, Mohamed SELEEM, Clement OPOKU-TEMENG, Haroon Taj MOHAMMAD, George NACLERIO
  • TETRAHYDRO-3H-PYRAZOLO QUINOLONE AND TETRAHYDRO-3H-PYRROLO[3,2-F]QUINOLINE -CONTAINING COMPOUNDS AND USES THEREOF
    Publication number: 20230312562
    Abstract: The present invention generally relates to tetrahydro-3H-pyrazolo-[4,3-f]-quinolone and tetrahydro-3H-pyrrolo-[3,2-f]quinoline-containing compounds as a tubulin polymerization inhibitor for the treatment of various cancers, and methods of uses thereof. Pharmaceutical compositions and the methods for treating those kinase related diseases are within the scope of this invention.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 5, 2023
    Applicant: Purdue Research Foundation
    Inventors: Herman O. Sintim, Neetu Dayal
  • Benzamide antibacterial agents
    Patent number: 11731964
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: August 22, 2023
    Assignee: Purdue Research Foundation
    Inventors: Herman O. Sintim, Mohamed Seleem, Clement Opoku-Temeng, Haroon Taj Mohammad, George Naclerio
  • 2,3-DISUBSTITUTED PYRIDO[3,4-B]PYRAZINE-CONTAINING COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20230219934
    Abstract: The present invention generally relates to 2,3-Disubstituted pyrido[3,4-b]pyrazine-containing compounds as a kinase inhibitor and methods of uses thereof. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
    Type: Application
    Filed: June 24, 2021
    Publication date: July 13, 2023
    Applicant: Purdue Research Foundation
    Inventors: Herman O. Sintim, Elizabeth Anne Larocque, Delmis E. Hernandez, Neetu Dayal
  • CONTINUOUS FLOW SONOGASHIRA COUPLING SYNTHESIS METHOD
    Publication number: 20230183246
    Abstract: The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.
    Type: Application
    Filed: May 13, 2021
    Publication date: June 15, 2023
    Applicant: Purdue Research Foundation
    Inventors: David Harley Thompson, Herman O. Sintim, Qingqing Qi, Shruti Biyani
  • CF3-, OCF3-, SCF3-, and SF5-Containing Antibacterial Agents
    Publication number: 20220249447
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant S. aureus (VISA and VRSA respectively) vancomycin-resistant Enterococcusfaecalis (VRE), and Clostridioides difficile. Pharmaceutical compositions and methods for treating those infection diseases are within the scope of this invention.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 11, 2022
    Inventors: Herman O. Sintim, George Naclerio
  • INHIBITORS OF CYCLIC MONO- AND DI-NUCLEOTIDE PHOSPHODIESTERASES AND THE USES THEREOF
    Publication number: 20220194957
    Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 23, 2022
    Applicant: Purdue Research Foundation
    Inventors: Herman O. Sintim, George Naclerio, Caroline Karanja
  • ALKYNYL NICOTINAMIDE COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20220089599
    Abstract: This invention relates to Alkynyl Nicotinamide compounds and their derivatives as kinase inhibitors. In addition, uses thereof for treatment of disease such as cancer and, in particular, acute myeloid leukemia are disclosed.
    Type: Application
    Filed: September 12, 2019
    Publication date: March 24, 2022
    Inventors: HERMAN O. SINTIM, ELIZABETH LAROCQUE, N. NAGANNA
  • INHIBITORS OF KINASE NETWORKS AND USES THEREOF
    Publication number: 20210371420
    Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: April 29, 2021
    Publication date: December 2, 2021
    Inventors: Herman O. Sintim, Neetu Dayal, Clement Opoku-Temeng
  • 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES
    Publication number: 20210198208
    Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.
    Type: Application
    Filed: March 1, 2021
    Publication date: July 1, 2021
    Inventor: Herman O. SINTIM
  • Inhibitors of kinase networks and uses thereof
    Patent number: 11040973
    Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 22, 2021
    Inventors: Herman O. Sintim, Neetu Dayal, Clement Opoku-Temeng
  • Dock derived compound against laminin receptor (37 LR) and uses thereof
    Patent number: 11022604
    Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 1, 2021
    Assignee: Purdue Research Foundation
    Inventors: Marxa L. Figueiredo, Charles Samuel Umbaugh, Herman O. Sintim, Adriana Diaz-Quinones
  • 4-substituted aminoisoquinoline derivatives
    Patent number: 11001559
    Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: May 11, 2021
    Assignee: Purdue Research Foundation
    Inventor: Herman O. Sintim
  • BENZAMIDE ANTIBACTERIAL AGENTS
    Publication number: 20210047316
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: March 29, 2019
    Publication date: February 18, 2021
    Inventors: Herman O. SINTIM, Mohamed SELEEM, Clement OPOKU-TEMENG, Haroon Taj MOHAMMAD, George NACLERIO
  • INHIBITORS OF KINASE NETWORKS AND USES THEREOF
    Publication number: 20200308173
    Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 1, 2020
    Inventors: Herman O. Sintim, Neetu Dayal, Clement Opoku-Temeng
  • Dock Derived Compound against Laminin Receptor (37 LR) and Uses thereof
    Publication number: 20200064334
    Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.
    Type: Application
    Filed: August 29, 2019
    Publication date: February 27, 2020
    Applicant: Purdue Research Foundation
    Inventors: Marxa L. Figueiredo, Charles Samuel Umbaugh, Herman O. Sintim, Adriana Diaz-Quinones
  • Dock derived compound against laminin receptor (37 LR) and uses thereof
    Patent number: 10438688
    Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: October 8, 2019
    Assignee: Purdue Research Foundation
    Inventors: Marxa L. Figueiredo, Charles Samuel Umbaugh, Herman O. Sintim, Adriana Diaz-Quinones
  • LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME
    Publication number: 20190209548
    Abstract: Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
    Type: Application
    Filed: November 19, 2018
    Publication date: July 11, 2019
    Inventors: Herman O. Sintim, Jie Zhou, Changhao Wang, Rena Lapidus
  • 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES
    Publication number: 20190177278
    Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 13, 2019
    Applicant: Purdue Research Foundation
    Inventor: Herman O. SINTIM