Patents by Inventor Herman Overkleeft

Herman Overkleeft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
    Patent number: 8609610
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 17, 2013
    Assignees: Trustees of Dartmouth College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
    Patent number: 8455431
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: June 4, 2013
    Assignees: Trustees of Dartmout College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof
    Publication number: 20120214732
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft