Patents by Inventor Herman Pel

Herman Pel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving the yield of a polypeptide
    Patent number: 9181573
    Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: November 10, 2015
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jan Metske Van Der Laan, Liang Wu, Johannes Andries Roubos, Lucie Parenicova, Alrik Pieter Los, Noel Nicolaas Maria Elisabeth Van Peij, Jan Herman Pel
  • METHOD FOR IMPROVING THE YEILD OF A POLYPEPTIDE
    Publication number: 20110318752
    Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.
    Type: Application
    Filed: March 8, 2010
    Publication date: December 29, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Jan Metske Van Der Laan, Liang Wu, Johannes Andries Roubos, Lucie Parenicova, Alrik Pieter Los, Noel Nicolaas Maria Elisabeth Van Peij, Jan Herman Pel
  • Genes from propionibacterium freudenreichii encoding enzymes involved in vitamin b12 biosynthesis
    Publication number: 20060183188
    Abstract: Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway of vitamin B12. The four enzymes are: A: cobyrinic acid a, c-diamide synthase; B: a bifunctional enzyme, which is a cobinamide kinase and a cobinamide phosphate guanyl transferase; C: a cobalamin 5-phosphate synthase; and D: an adenosyl transferase. Genes encoding the four enzymes can be placed in Propionibacteria shuttle vectors and used to transform Propionibacteria hosts, in order to improve the production of vitamin B12 or a precursor thereof on an industrial scale during fermentation.
    Type: Application
    Filed: July 25, 2003
    Publication date: August 17, 2006
    Inventors: Herman Pel, Sylvia Hopper