Abstract: Methods and/or hormone-producing cells for improving the development and/or maturation of eggs and/or sperm in fish using hormone administration. The methods may comprise providing the fish with cells producing the hormone. Preferred hormones are fertility hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH) or chorionic gonadotropin (CG) or a functional part, derivative and/or analogue thereof.

Abstract: Provided is a method and system for screening chemical compounds or compositions, wherein replicating entities are introduced into the yolk of an (un)fertilized egg or embryo. The method may be extended to elucidate the mechanism-of-action of functional chemical compounds or compositions in the same method and system. The method and system may also be employed for identifying marker genes, marker proteins or marker metabolites.

Abstract: The invention is concerned with means and methods for improving the development and/or maturation of eggs and/or sperm in fish using hormone administration comprising providing said fish with cells producing said hormone. Preferred hormones are fertility hormones such as luteinizing hormone (LH), follicle stimulating hormone (FSH)or chorionic gonadotropin (CG) or a functional part, derivative and/or analogue thereof.

Abstract: The present invention provides proteinaceous molecules to encode solutions to computational problems. In one aspect, a proteinaceous molecule is used as a representation of a combination of values for variables of a computational problem. In a second aspect, a library of proteinaceous molecules representing essentially all relevant solutions to at least one computational problem are used. The invention further provides a nucleic acid library encoding a library of proteinaceous molecules according to the invention. In another aspect, the invention includes a method for detecting a proteinaceous molecule representing a combination of values for variables of a computational problem comprising contacting a library of proteinaceous molecules of the invention, with a set of binding molecules designed for binding to proteinaceous molecules representing solutions.

Abstract: A computational method that makes use of DNA molecules is disclosed. The method can be summarized as follows. First, a set of DNA molecules representing (by their sequences) all possible assignments to all variables of a given computational problem is generated (this is the so-called combinatorial library of the problem). Second, all the DNA molecules representing assignments which do not correspond to solutions of the problem are inactivated (blocked) for reproduction or detection. Finally, one has to check only whether any active (non-blocked) molecules remain: a solution of the problem exists if and only if any such molecules remain. In principle this allows to solve computationally difficult problems. We illustrate our method by outlining a solution for the famous satisfiability problem using both a polymerase chain reaction (PCR) method and a fluorescent quenching assay.