Patents by Inventor Herman Slijkhuis

Herman Slijkhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for oxidation of steroids and genetically engineered cells used therein
    Publication number: 20040067579
    Abstract: An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins, of catalyzing an oxidation step in the biological pathway for conversion of cholesterol into hydrocortisone, which step is selected from the group consisting of:
    Type: Application
    Filed: June 16, 2003
    Publication date: April 8, 2004
    Applicant: Aventis Pharma S.A.
    Inventors: Herman Slijkhuis, Eric Bastiaan Smaal, Gerardus Cornelis Maria Selten
  • Process for oxidation of steroids and genetically engineered cells used therein
    Patent number: 6632633
    Abstract: An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins of catalyzing an oxidation step in the biological pathway, for conversion of cholesterol into hydrocortisone, which step is selected from the group consisting of: the conversion of cholesterol to pregnenolone; the conversion of pregnenolone to progesterone; the conversion of progesterone to 17&agr;-hydroxyprogesterone; the conversion of 17&agr;-hydroxyprogesterone to cortexolone; the conversion of cortexolone to hydrocortisone, and the corresponding control sequences effective in that host.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: October 14, 2003
    Assignee: Aventis Pharma, S.A.
    Inventors: Herman Slijkhuis, Eric Bastiaan Smaal, Gerardus Cornelis Maria Selten
  • Process for oxidation of steroids and genetically engineered cells used therein
    Publication number: 20030108982
    Abstract: An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins, of catalyzing an oxidation step in the biological pathway for conversion of cholesterol into hydrocortisone, which step is selected from the group consisting a of:
    Type: Application
    Filed: February 26, 2002
    Publication date: June 12, 2003
    Applicant: Aventis Pharma S.A.
    Inventors: Herman Slijkhuis, Eric Bastiaan Smaal, Gerardus Cornelis Maria Selten
  • Process for oxidation of steroids and genetically engineered cells used therein
    Patent number: 6171836
    Abstract: An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins, of catalyzing an oxidation step in the biological pathway for conversion of cholesterol into hydrocortisone, which step is selected from the group consisting of: the conversion of cholesterol to pregnenolone; the conversion of pregnenolone to progesterone; the conversion of progesterone to 17&agr;-hydroxyprogesterone; the conversion of 17&agr;-hydroxyprogesterone to cortexolone; the conversion of cortexolone to hydrocortisone, and the corresponding control sequences effective in said host.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: January 9, 2001
    Assignee: Hoechst Marion Roussel
    Inventors: Herman Slijkhuis, Eric Bastiaan Smaal, Gerardus Cornelis Maria Selten
  • Expression cassette operable in a recombinant host
    Patent number: 5869283
    Abstract: An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins, of catalyzing an oxidation step in the biological pathway for conversion of cholesterol into hydrocortisone, which step is selected from the group consisting of:the conversion of cholesterol to pregnenolone;the conversion of pregnenolone to progesterone;the conversion of progesterone to 17.alpha.-hydroxy-progesterone;the conversion of 17.alpha.-hydroxyprogesterone to cortexolone;the conversion of cortexolone to hydrocortisone, and thecorresponding control sequences effective in said host.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: February 9, 1999
    Assignee: Roussel Uclaf
    Inventors: Herman Slijkhuis, Eric Bastiaan Smaal, Gerardus Cornelis Maria Selten