Patents by Inventor Herman Staats

Herman Staats has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10245319
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 2, 2019
    Assignee: Duke University
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Publication number: 20180099044
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Application
    Filed: September 7, 2017
    Publication date: April 12, 2018
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Patent number: 9782475
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: October 10, 2017
    Assignee: Duke University
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Publication number: 20150023909
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 22, 2015
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Patent number: 8802076
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: August 12, 2014
    Assignee: Duke University
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Publication number: 20120107268
    Abstract: Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1?, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
    Type: Application
    Filed: October 4, 2011
    Publication date: May 3, 2012
    Inventors: Soman Abraham, Kam Leong, Herman Staats, Ashley St. John
  • Publication number: 20050031630
    Abstract: A composition for eliciting an immune response to an immunogen comprises an immunogen in combination with a mast cell membrane activator such as compound 48/80. Any suitable immunogen may be employed, such as an antibody-inducing determinant, a lipid, a peptide (e.g., an antibody-inducing peptide), a carbohydrate, an immunogen derived from a virus or cancer cell, etc. Methods of use are also described.
    Type: Application
    Filed: April 2, 2004
    Publication date: February 10, 2005
    Inventors: Salvatore Pizzo, Justin Hart, James McLachlan, Herman Staats, Soman Abraham