Patents by Inventor Herman Tolboom

Herman Tolboom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
    Publication number: 20220098548
    Abstract: One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Martin Yarmush, Basak E. Uygun, Korkut Uygun, Maria-Louisa Izamis, Alejandro Soto-Gutierrez, Herman Tolboom, Hiroshi Yagi, Carley Shulman, Jack Milwid
  • Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
    Patent number: 11136553
    Abstract: One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: October 5, 2021
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Martin Yarmush, Basak E. Uygun, Korkut Uygun, Maria-Louisa Izamis, Alejandro Soto-Gutierrez, Herman Tolboom, Hiroshi Yagi, Carley Shulman, Jack Milwid
  • ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
    Publication number: 20150322404
    Abstract: One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
    Type: Application
    Filed: April 7, 2015
    Publication date: November 12, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Martin Yarmush, Basak E. Uygun, Korkut Uygun, Maria-Louisa Izamis, Alejandro Soto-Gutierrez, Herman Tolboom, Hiroshi Yagi, Carley Shulman, Jack Milwid
  • ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
    Publication number: 20130323708
    Abstract: One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
    Type: Application
    Filed: June 30, 2010
    Publication date: December 5, 2013
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Martin Yarmush, Basak E. Uygun, Mustafa Korkut Uygun, Maria Louisa Izamis, Alejandro Soto-Gutierrez, Herman Tolboom, Hiroshi Yagi, Carley Shulman, John Miles Milwid