Patents by Inventor Herman Turndorf

Herman Turndorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient
    Patent number: 7357944
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: April 15, 2008
    Assignees: New York University, Yissum Research Development, Co
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomak compositions and methods of preparation
    Patent number: 6926905
    Abstract: Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized liposomes encapsulating the local anesthetic are rehydrated by agitating them in an aqueous medium. Preferably this method includes the further step of washing the rehydrated liposomes in hyperosmotic saline solution.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: August 9, 2005
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, New York University
    Inventors: Gilbert J. Grant, Elijah M. Bolotin, Yechezkel Barenholz, Herman Turndorf
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Publication number: 20040156891
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Applicants: New York University, Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Patent number: 6696080
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: February 24, 2004
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, New York University
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomak compositions and methods of preparation
    Publication number: 20040018230
    Abstract: Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized liposomes encapsulating the local anesthetic are rehydrated by agitating them in an aqueous medium. Preferably this method includes the further step of washing the rehydrated liposomes in hyperosmotic saline solution.
    Type: Application
    Filed: July 16, 2003
    Publication date: January 29, 2004
    Applicant: New York University
    Inventors: Gilbert J. Grant, Elijah M. Bolotin, Yechezkel Barenholz, Herman Turndorf
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Patent number: 6162462
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising `GMV` (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 19, 2000
    Assignees: New York University, Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Single limb breathing circuit assembly and absorber
    Patent number: 4232667
    Abstract: New and improved single limb breathing circuit assembly for use in a circle absorbed anesthetic system is disposed within and surrounded by the expiratory limb to provide for heating of the inhaled gases by the exhaled gases. Valve means insure that substantially all exhalation occurs in the expiratory limb and that substantially all inhalation occurs in the inspiratory breathing limb to prevent re-breathing of exhaled carbon dioxide. The absorber comprises inlet and internal outlet conduits which combine to assure the flow of gases from the absorber at high humidity levels. Valve means are also provided to proportion the fresh gas inflow to the absorber between the inlet and outlet conduits to enable control of the humidity of the gases flowing from the absorber within a predetermined range. The various portions of the system are arranged so as to minimize both heat and moisture loss in the inhaled gases passing through the absorber for conveyance to the patient.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: November 11, 1980
    Inventors: Jack Chalon, Sivam Ramanathan, Herman Turndorf