Patents by Inventor Herman Vandenburgh

Herman Vandenburgh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCEMENT OF SKELETAL MUSCLE STEM CELL ENGRAFTMENT BY DUAL DELIVERY OF VEGF AND IGF-1
    Publication number: 20170232074
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 17, 2017
    Inventors: David J. Mooney, Cristina Borselli, Herman Vandenburgh, Eduardo Silva, Lin Wang, I, Dmitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
    Patent number: 9610328
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: April 4, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Cristina Borselli, Herman Vandenburgh, Dimitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Enhancement Of Skeletal Muscle Stem Cell Engraftment By Dual Delivery Of VEGF And IGF-1
    Publication number: 20130177536
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Application
    Filed: March 7, 2011
    Publication date: July 11, 2013
    Applicants: Brown University, President and Fellows of Harvard College
    Inventors: David J. Mooney, Cristina Borselli, Herman Vandenburgh, Eduardo Silva, Lin Wang, Dmitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Tissue sensor and uses thereof
    Publication number: 20060105357
    Abstract: Described are assemblies for screening a compound for bioactivity, the assemblies comprising a tissue and a sensor. A change in a biological parameter is measured by the sensor, such that a change in a parameter occurring when the tissue is contacted with a candidate compound is detected by the sensor. Assemblies provided herein include single sensor/tissue assemblies and arrays of such assemblies, including plates comprising tissues in combination with one or more sensors. Also provided are methods of screening a compound using tissue/sensor tissue assemblies as described.
    Type: Application
    Filed: February 4, 2005
    Publication date: May 18, 2006
    Inventors: Frank Benesch, Victoria Barbata, Robert Valentini, Herman Vandenburgh, Gregory Crawford
  • Delivery of an organized tissue to an organism
    Publication number: 20050260178
    Abstract: A sleeve organized tissue is formed of a biocompatible structure surrounding organized tissue in at least one dimension and along a length of the tissue. In certain preferred embodiments the tissue is attached to the sleeve, subjecting the organized tissue to internal tension within the sleeve. Methods of providing organized tissue within a sleeve and delivering protein to a mammal are also disclosed.
    Type: Application
    Filed: March 20, 2003
    Publication date: November 24, 2005
    Inventors: Herman Vandenburgh, Robert Valentini