Abstract: This invention relates to compounds of formula (I), wherein R1 and R3 independently represent fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; R2 represents hydrogen, fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; X represents O, S, NH or N(C1-C3-alkyl); and Ar represents an unsubstituted or at least monosubstituted aryl or heteroaryl. Said compounds are inhibitors of poly(ADP-ribose) polymerase (PARP), and may be used for the treatment of a variety of disorders.

Abstract: A process and apparatus for producing a dust-free blend of additives for use in plastic manufacture wherein the materials are extruded through apertures in a thin die plate supported by a strong die plate support, the apertures in the die plate being larger at their inlet ends than at their outlet ends, and apertures in the die plate support being larger than the die plate apertures, and the product being strand-like pellets of the additive materials.