Abstract: New acylthiomethyl esters of cephalosporins have the formula ##SPC1##Wherein R.sub.1 is .alpha.-aminobenzyl; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is lower alkyl; and X is tetrazolylthio or (lower alkyl)tetrazolylthio. They are useful as antibacterial agents.

Abstract: 3-Heterothio derivatives of [[(alkoxy)thiocarbonyl]oxy]acetyl cephalosporins having the formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, pyridyl, thienyl or furyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is 1-oxopyridinyl or a five membered heterocycle containing only nitrogen and carbon or nitrogen, carbon and oxygen or sulfur in the ring; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: 4-(1,2,4-Oxadiazolylformamidoalkyl)phenylsulfonyl ureas e.g. 1-cyclohexyl-3-[p-.beta.-(5-methyl-1,2,4-oxadiazole-3-carbonylaminoethyl)p henylsulfonyl]urea, are useful as anti-inflammatory and hypoglycemic agents.

Abstract: New 2-(thiocarbonylamino)acetamido-7.alpha.-methoxy cephalosporanic acid compounds of the following general formula, and their salts, ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(halo)lower alkyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl, furyl, thienyl or pyridyl; R.sub.2 and R.sub.4 each is hydrogen or lower alkyl; R.sub.3 is lower alkyl, phenyl or phenyl-lower alkyl; and X is hydrogen, lower alkanoyloxy or azido; are useful as antibacterial agents.

Abstract: Amino-1,2,4-oxadiazolyl-3-acetyl penicillins and cephalosporins of the general formula ##SPC1##Wherein A is either ##SPC2##R.sub.1 and R.sub.2 are independently selected from hydrogen and lower alkyl or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a heterocyclic ring; R.sub.3 is hydrogen, lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or pyridyl; R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl, benzhydryl, a salt forming ion, trimethylsilyl, or ##EQU1## R.sub.5 is lower alkyl, phenyl or phenyl-lower alkyl; X is hydrogen, lower alkoxy, lower alkanoyloxy, lower alkylmercapto, the radical of a nitrogen base; or certain heterocyclic thio moieties; are disclosed. They are useful as antibacterial agents.

Abstract: 3-Heterothio derivatives of [(alkoxycarbonyl)oxyacetyl]cephalosporins which have the formula ##SPC1## tri(lowerWherein R.sub.1 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl or certain heterocyclic groups; R.sub.2 is lower alkyl; R.sub.3 is hydrogen, lower alkyl, tri(lower alkyl)silyl, tri(lowe alkyl)stannyl, a salt forming ion, or ##EQU1## R is lower alkyl, phenyl, or phenyl-lower alkyl; R.sub.4 is a five-membered nitrogen and sulfur or oxygen-containing ring system; are useful as antibacterial agents.

Abstract: 1,2,4-Oxadiazolonylacetyl penicillins and cephalosporins of the general formula ##SPC1##Wherein A is either ##SPC2##R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.2 is hydrogen, lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or pyridyl; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl, a salt forming ion, trimethylsilyl, benzhydryl, or ##EQU1## R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; and X is hydrogen, lower alkoxy, lower alkanoyloxy, lower alkylmercapto, the radical of a nitrogen base, or certain heterocyclic thio moieties; are disclosed. They are useful as antibacterial agents.

Abstract: [(Thiophosphono)acetamido]cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen; R.sub.2, R.sub.3 and R.sub.4 each is lower alkyl, or aralkyl; and X is hydrogen, hydroxy or lower alkanoyloxy; are useful as antibacterial agents.

Abstract: 3-Alkylthio- and 3-heterothio derivatives of [[(thioalkoxy)thiocarbonyl]oxyl]acetylcephalosporins having the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, pyridyl, thienyl or furyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is lower alkyl, a five-membered heterocycle containing only nitrogen and carbon or nitrogen, carbon and oxygen or sulfur in the ring or pyridine-N-oxide; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: (Carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl or furyl; R.sub.2 is lower alkyl, lower alkoxymethyl, phenyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkanoyloxy; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: New cyanomethylthioacetylcephalosporins of the following general formula, and their salts ##EQU1## wherein R is hydrogen or a salt forming ion of the group consisting of aluminum, alkali metal, alkaline earth metal, lower alkylamine, phenyl-lower alkylamine, N,N-dibenzylethylenediamine, procaine or lower alkylpiperidine; R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, phenyl, hydroxyphenyl, chlorophenyl, benzyl, phenethyl, or R.sub.1 and R.sub.2 together complete a cyclopentyl or cyclohexyl group; R.sub.3 is phenyl, substituted phenyl or thienyl, said phenyl substituents being halogen, lower alkyl, amino or lower alkoxy; and X is hydrogen, lower alkoxy, lower alkylthio or lower alkanoyloxy; are useful as antibacterial agents.

Abstract: [[(Thioalkoxy)thiocarbonyl]oxy]acetyl cephalosporin derivatives of the general formula ##SPC1##Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri-(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU1## is hydrogen, lower alkyl, phenyl, thienyl, furyl or pyridyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, lower alkanoyloxy, azido or pyridyl; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: New cyanomethylthioacetylcephalosporins of the following general formula, and their salts ##SPC1##Wherein R is hydrogen or a salt forming ion of the group consisting of aluminum, alkali metal, alkaline earth metal, lower alkylamine, phenyl-lower alkylamine, N,N'-dibenzylethylenediamine, procaine or lower alkylpiperidine; R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, phenyl, hydroxyphenyl, chlorophenyl, benzyl, phenethyl or R.sub.1 and R.sub.2 together complete a cyclopentyl or cyclohexyl group; R.sub.3 is cyclo-lower alkyl, cyclo-lower alkenyl or cyclo-lower alkadienyl; and X is hydrogen, lower alkanoyloxy, lower alkoxy or lower alkylthio.

Abstract: New cyanomethylthioacetylcephalosporins of the following general formula, and their salts ##SPC1##Wherein R is hydrogen or a salt forming ion of the group consisting of aluminum, alkali metal, alkaline earth metal, lower alkylamine, phenyl-lower alkylamine, N,N'-dibenzylethylenediamine, procaine or lower alkylpiperidine; R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, phenyl, hydroxyphenyl, chlorophenyl, benzyl, phenethyl, or R.sub.1 and R.sub.2 together complete a cyclopentyl or cyclohexyl group; R.sub.3 is hydrogen, lower alkyl or lower alkenyl; and X is lower alkoxy or lower alkylthio; are useful as antibacterial agents.

Abstract: 3-Heterothio(carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl, or pyridyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.