Abstract: Peptides of the formula IA-B-C-E-F-K-P-G-M-F'-I (I),wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides.

Abstract: A compound of the formula ##STR1## in which the symbols have the following meaning: X is a monocyclic radical having 3, 4 or 5 ring atoms,R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.12 and R.sup.13 are, for example, an alkyl radical,q is zero or 1,L is, for example, a methylene group andA is the radical, for example, of a heterocycleare highly active as antagonists of angiotensin II receptors.They can be used as pharmaceuticals or diagnostics.

Abstract: Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their useCompounds of the formula (I) ##STR1## in which R.sup.1 is, for example, ethyl,R.sup.2 is, for example, methyl,n is, for example, zero,R.sup.3 is, for example, COOH, andR.sup.4 is, for example, SO.sub.2 NHCONHCH.sub.3are highly active antagonists of angiotensin II receptors.

Abstract: Peptides of the formula IZ-P-A-B-C-E-F-K-(D)Q-G-M-F'-I (I)and the physiologically tolerated salts thereof, are described.They have an excellent bradykinin-antagonistic action.They are obtained by reacting reacting a fragment with a C-terminal free carboxyl group or its activated derivative with a corresponding fragment with an N-terminal free amino group or assembling the peptide stepwise, where appropriate eliminating in the compound obtained in this way one or more protective groups introduced temporarily to protect other functionalities, and where appropriate converting the compounds of the formula I obtained in this way into the physiologically tolerated salt thereof.

Abstract: Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R.sup.1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings:R.sup.1 is (C.sub.2 -C.sub.10)-alkyl,Z is nitrogen,X and Y are independently of one another CR.sup.2,L is --CH.sub.2 --,q is zero or 1,A is a biphenyl radical which is substituted for example by R.sup.15,R.sup.2 is halogen or hydrogen,R.sup.15 is SO.sub.2 --NH--CO--OR.sup.6 andR.sup.6 is phenyl,are highly active antagonists of angiotensin II receptors.

Abstract: Imidazo-fused iso- and heterocycles, process for their preparation, compositions containing them and their useA compound of the formula ##STR1## in which the symbols have the following meaning: X is a monocyclic radical having 3,4 or 5 ring atoms,R.sup.1,R.sup.2,R.sup.3,R.sup.4,R.sup.12 and R.sup.13 are, for example, an alkyl radical,q is zero or 1,L is, for example, a methylene group andA is the radical, for example, of a heterocycleare highly active as antagonists of angiotensin II receptors. They can be used as pharmaceuticals or diagnostics.

Abstract: The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.

Abstract: The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.

Abstract: The invention relates to compounds of the formula (I) ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, and the other radicals have the meaning defined in the description, a process for the preparation thereof, agents containing these, and the use thereof.

Abstract: New substituted phenylpiperazine derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the indicated meaning, and their physiologically tolerated salts and a process for their preparation are described. The compounds exhibit sedative and aggression-inhibiting effects on livestock. Furthermore, compounds of the formula I' ##STR2## in which n, A, R.sup.2, R.sup.3 and R.sup.4 have the indicated meanings, and their physiologically tolerated salts are claimed for the sedation and inhibition of aggression of livestock.

Abstract: The invention relates to peptides of the formula IR.sup.4 -A.sup.5 -A.sup.6 -A.sup.7 (I)in which R.sup.4 denotes an acyl group, R.sup.5 denotes D-Lys or Lys, A.sup.6 denotes the radical of phenylalanine, N-methylphenylalanine, 4-alkoxyphenylalanine or 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and R.sup.7 denotes a basic radical, processes for their preparation and their use.

Abstract: The invention relates to peptides of the formula IR.sup.4 --A.sup.5 --A.sup.6 --A.sup.7 (I)in which R.sup.4 denotes an acyl group, R.sup.5 denotes D-Lys or Lys, A.sup.6 denotes the radical of phenylalanine, N-methylphenylalanine, 4- alkoxyphenylalanine or 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and R.sup.7 denotes a basic radical, processes for their preparation and their use.

Abstract: Neuroleptically active compounds of the formula ##STR1## wherein R.sup.6 and R.sup.10 are --H or CH.sub.3 ; R.sup.7 and R.sup.8 are independently --H, --F, --Cl, or --CH.sub.3 ; and R.sup.9 is --F, --Cl, --CH.sub.3, or --OCH.sub.3.

Abstract: What are disclosed are 1,4-benzodiazepines, having a carbamoyloxyamino group, of the following formula I ##STR1## tautomers thereof of the following formula IA ##STR2## physiologically tolerated salts thereof, said compounds having an anxiolytic action without sedating, a process for the preparation of these new compounds, pharmaceutical agents which contain the active compounds, and methods for treating anxiety states with said compounds.

Abstract: Heterocyclic, spiro-linked amidines of the formula I ##STR1## and their physiologically acceptable salts, in which (a) n is 1 or 2; (b) R.sup.1 and R.sup.2 are hydrogen or alkyl radicals which, together with the nitrogen atom, can form a 5-, 6- or 7-membered ring which can be substituted by C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.2 -alkoxy, hydroxyl or C.sub.1 -C.sub.4 -alkoxy-carbonyl groups and in which one of the carbon atoms can also be replaced by an oxygen, sulfur or nitrogen atom, it being possible for the nitrogen atom to be substituted by hydrogen, by the formyl group or by a phenyl radical, which can in turn be monosubstituted or polysubstituted by a C.sub.1 to C.sub.4 -alkyl group or an alkoxy, methylenedioxy, hydroxyl, halogen, nitro or amino group, or it being possible for the nitrogen atom to be substituted by a C.sub.1 -C.sub.4 -alkyl group, or in which R.sup.1 represents hydrogen and R.sup.2 represents a C.sub.5 -C.sub.8 -cycloalkyl radical which can be substituted by C.sub.1 -C.sub.

Abstract: Phenylpiperazine derivatives of the formula I ##STR1## in which R.sup.1 denotes hydrogen or C.sub.1 -C.sub.6 alkyl,R.sup.2 denotes hydrogen or one or several, identical or different substituents selected from the group of C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, trifluoromethyl, hydroxy, nitro, amino and methylene-dioxy,R.sup.3 denotes hydrogen, hydroxy, C.sub.1 -C.sub.6 alkanoyloxy, andn is 1 or 2,and the physiologically acceptable salts thereof, processes for their manufacture and medicaments containing or consisting of said compounds.

Abstract: The invention relates to hexahydro-1H-indeno/1,2-b/pyridines and a process for their manufacture. These compounds and the physiologically tolerable salts thereof are useful as agents for the treatment of psychic diseases.

Abstract: 2-Carboxamido-substituted tetracyclines of the general formula ##SPC1##A process for their preparation and compositions containing these compounds.