Patents by Inventor Hermann Graf

Hermann Graf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8461285
    Abstract: The present invention relates to a process for the catalytic preparation of polyetherols, wherein the power input by means of at least one stirrer and/or by means of at least one pump, based on the reactor volume, is in the range from 0.001 to 8.2 kW/m3.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: June 11, 2013
    Assignee: BASF SE
    Inventors: Fatemeh Ahmadnian, Vinit Chilekar, Andreas Brodhagen, Achim Loeffler, Hermann Graf
  • Publication number: 20120059142
    Abstract: A process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides and/or their esters, preferably isophthalic acid, phthalic acid and terephthalic acid and more preferably isophthalic acid, in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, comprises deactivating the catalyst after the polycondensation by using phosphoric acid in a molar ratio of 1:1 to 1:3.5 for catalyst to phosphoric acid.
    Type: Application
    Filed: September 6, 2011
    Publication date: March 8, 2012
    Applicant: BASF SE
    Inventors: Hermann Graf, Ulrike Mahn, Stefan Käshammer, Günter Scherr, Christian Nitschke
  • Publication number: 20120059143
    Abstract: The subject of the present invention is a process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, which process comprises heating the reaction mixture in two or more phases in the atmospheric-pressure reaction stage wherein the heating phases are interrupted by at least one phase in which the temperature is kept constant.
    Type: Application
    Filed: September 7, 2011
    Publication date: March 8, 2012
    Applicant: BASF SE
    Inventors: Gerlinde Tischer, Ulrike Mahn, Stefan Käshammer, Hermann Graf, Christian Seitz, Christian Nitschke, Dieter Rodewald
  • Publication number: 20110224396
    Abstract: The present invention relates to a process for the catalytic preparation of polyetherols, wherein the power input by means of at least one stirrer and/or by means of at least one pump, based on the reactor volume, is in the range from 0.001 to 8.2 kW/m3.
    Type: Application
    Filed: March 8, 2011
    Publication date: September 15, 2011
    Applicant: BASF SE
    Inventors: Fatemeh AHMADNIAN, Vinit Chilekar, Andreas Brodhagen, Achim Löffler, Hermann Graf
  • Publication number: 20110224397
    Abstract: The present invention relates to a process for preparing polyetherols in the presence of basic catalysts, wherein propylene oxide (PO) and/or ethylene oxide (EO) whose summated contents of aldehydes, expressed by the contents determined by gas chromatography or titrimetrically using the bisulfite method and calculated for propionaldehyde, do not exceed the value of 300 ppm and of allyl alcohol determined by gas chromatography do not exceed the value of 2500 ppm and of water determined by Karl-Fischer titration do not exceed the value of 1700 ppm and of acid, expressed by the contents determined by acid-base titration and calculated for acetic acid, do not exceed the value of 100 ppm and of carbon dioxide determined by KOH titration do not exceed the value of 500 ppm are used.
    Type: Application
    Filed: March 8, 2011
    Publication date: September 15, 2011
    Applicant: BASF SE
    Inventors: Thomas OSTROWSKI, Anne-Kathrin Merten, Achim Löffler, Hermann Graf
  • Patent number: 7579393
    Abstract: The invention relates to mixtures (1) comprising (a) polytetrahydrofuran and (b) stabilizers having a molecular weight of from 600 g/mol to 10000 g/mol and comprising at least two phenolic groups.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: August 25, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Hauke Malz, Dieter Rodewald, Hermann Graf
  • Publication number: 20090182113
    Abstract: The present invention relates to a process for producing a polyurethane elastomer fiber, which comprises a) reacting polymeric diol with a substance reactive therewith to form an OH-terminated prepolymer, b) reacting the OH-terminated prepolymer with a diisocyanate to form an isocyanate-terminated prepolymer, c) reacting the isocyanate-terminated prepolymer with a chain extender, if appropriate a chain-terminating agent and if appropriate further additives to form the polyurethane elastomer, and d) spinning the polyurethane elastomer to form a fiber, in which there are less than 15% by weight of further polyurethane elastomers in the fiber. The present invention further relates to a polyurethane elastomer fiber obtainable by such a process, to its use for producing textiles, for example wovens or knits, and also to the use of a polyurethane elastomer for producing such a fiber.
    Type: Application
    Filed: April 16, 2007
    Publication date: July 16, 2009
    Applicant: BASF SE
    Inventors: Dieter Rodewald, Hermann Graf
  • Publication number: 20070129487
    Abstract: The invention relates to mixtures (1) comprising (a) polytetrahydrofuran and (b) stabilizers having a molecular weight of from 600 g/mol to 10000 g/mol and comprising at least two phenolic groups.
    Type: Application
    Filed: December 30, 2004
    Publication date: June 7, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Hauke Malz, Dieter Rodewald, Hermann Graf
  • Patent number: 6274759
    Abstract: Diisocyanates of the formula (I) where R1 is a C1-C10-hydrocarbon radical and R3 is a C1-Cl2-hydrocarbon group and n is an integer from 1 to 10, are described.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: August 14, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Hermann Graf, Udo Rotermund, Günter Mohrhardt
  • Patent number: 6162920
    Abstract: The invention relates to pharmacologically active compounds that have the ability to influence the polymerisation and depolymerisation of tubulin.A range of natural mitosis toxins are used as anti-tumor agents or are in the process of being clinically tested. There are various classes of such mitosis toxins that either demonstrate their cytotoxic action by inhibiting the polymerisation of microtubules in the spindle system (for example, Vinca alkaloids, colchicine) or achieve their cytotoxic action by a GTP-independent increase in the polymerisation of the tubulin and by preventing the depolymerisation of microtubules (for example, taxol, taxoters).Owing to their physico-chemical properties, hitherto not understood, and as a result of the characteristics of neoplastic cells, mitosis toxins have a certain selectivity for tumor cells, but there still remains a not inconsiderable cytotoxicity towards non-transformed cells.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: December 19, 2000
    Assignee: Schering Aktiensgesellschaft
    Inventors: Ulrich Klar, Gunter Neef, Hermann Graf
  • Patent number: 6117895
    Abstract: Compounds of formula I ##STR1## are useful for treating TNF-mediated diseases.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: September 12, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Wachtel, Hermann Graf, Herbert Schneider, Daryl Faulds, H. Daniel Perez, Harald Dinter
  • Patent number: 6060501
    Abstract: A pharmaceutically composition for treating MS comprising an effective amount of a combination of a PDE IV inhibitor and an anti-inflammatory and immunomodulatory drug in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: May 9, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Wachtel, Peter-Andreas Loschmann, Hermann Graf, H. Daniel Perez
  • Patent number: 5981684
    Abstract: The invention relates to highly functionalized polyurethanes which are synthesized from molecules containing the functional groups A(B).sub.n, where A is an NCO group or a group reactive with an NCO group, B is an NCO group or a group reactive with an NCO group, A is reactive with B and n is a positive number and is at least equal to 2.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: November 9, 1999
    Assignee: Basf Aktiengesellschaft
    Inventors: Bernd Bruchmann, Frank Wingerter, Hermann Graf, Stefan Wolff
  • Patent number: 5965609
    Abstract: The invention concernes borneol esters of general formula (I), in which R.sup.1 means T--C(O)--CH(OR.sup.6)--(NR.sup.7a R.sup.7b)--R.sup.8, C(O)--CH(OR.sup.6a)--CH[NR.sup.7 (C(O)--CH(OR.sup.6b)--CH (NR.sup.7a R.sup.7b)--R.sup.8a)]--R.sup.8b ; R.sup.7a R.sup.7b are identical or different and means R.sup.7 ; R.sup.7 means hydrogen, A, --C(O)R.sup.12, --C(O)OR.sup.12, --C(O)SR.sup.12, --C(O)NHR.sup.9d, --C(O)NR.sup.9d R.sup.9e, --SO.sub.2 R.sup.12, C.sub.1 -C.sub.10 alkyl; R.sup.8a, R.sup.8b are identical or different and mean R.sup.8 ; R.sup.8 means (i), heteroaryl substituted by X.sup.3, C.sub.7 -C.sub.16 aralkyl, alkyl; A is B--[O--(CH.sub.2).sub.t --C(O)].sub.0 or 1-, farnesyl--P(O)(OR.sup.9d)--O--(CH.sub.2).sub.t --C(O)--; B means protein kinase-inhibitors or farnesyl protein transferase-inhibitors such as for example farnesyl (ii); and T is a bond, Z.sup.i or a group (iii). The borneol esters can influence tubulin polymerisation and tubulin depolymerisation.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: October 12, 1999
    Assignee: Schering AG
    Inventors: Ulrich Klar, Hermann Graf, Gunter Neef, Siegfried Blechert
  • Patent number: 5919887
    Abstract: A process for decoloring polyisocyanates containing isocyanurate and uretdione groups comprises treating the demonomerized polyisocyanates containing isocyanurate and uretdione groups with oxygen.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: July 6, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hermann Graf, Ernst Deuker, Stefan Wolff, Ludwig Schuster, Serge Wack, Richard Hardt
  • Patent number: 5792792
    Abstract: The invention relates to borneol derivatives of general formula I ##STR1## in which R.sup.1 means C(O)--CH(OR.sup.6)--CH(NHR.sup.7)--R.sup.8,R.sup.2 means hydrogen, --OH, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, --OC(O)R.sup.9a, --OSO.sub.2 R.sup.9a, --OP(O)(OH).sub.2, NHR.sup.9a, NR.sup.9a R.sup.9b,R.sup.3 means hydrogen, --OH, C.sub.1 -C.sub.10 alkoxy, --OC(O)R.sup.9b, --OSO.sub.2 R.sup.9b, --OP(O)(OH).sub.2, orR.sup.2, R.sup.3 together mean an oxygen atom,R.sup.4 means hydrogen, C.sub.1 -C.sub.10 alkyl, --(CH.sub.2).sub.n --OR.sup.11a,R.sup.5 means hydrogen, C.sub.1 -C.sub.10 alkyl, --(CH.sub.2).sub.p --OR.sup.11b, orR.sup.4, R.sup.5 together mean an oxygen atom, a=CHR.sup.10 group,n means 0 to 8,p means 1 to 8,R.sup.7 means --C(O)R.sup.12, --SO.sub.2 R.sup.12, --C(O)OR.sup.12, --C(O)NHR.sup.9d, --C(O)NR.sup.9d R.sup.9e, ##STR2## R.sup.8 means aryl, R.sup.9a-e, R.sup.12 are the same or different and mean C.sub.1 -C.sub.10 alkyl, C.sub.4 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.16 aralkyl,R.sup.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: August 11, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Hermann Graf, Gunter Neef, Siegfried Blechert
  • Patent number: 5556918
    Abstract: Polymeric materials (I) are obtainable by reacting1. a polymer II comprisinga) from 80 to almost 100 mol % of a C.sub.1 -C.sub.25 -alkyl ester of an .alpha.,.beta.-unsaturated carboxylic acid,b) from 0 to 20 mol % of a further monomer,c) tetrahydrofuran hydroperoxide as polymerization initiator and, if required,d) a further polymerization initiator and/or regulator by means of which the majority of the polymer chains of the polymer II are terminated at one of their ends by a hydroxyl group,2. with a polyfunctional isocyanate III to give a reaction product IV, the amount of isocyanate groups being from 1.2 to 3.0 mol per mol of hydroxyl groups of II, and3. reacting IV with ammonia or with a compound V which has an amino function reactive toward isocyanates.The polymeric materials can be used as dispersing resins for pigment-containing coatings, in particular for the production of magnetic recording materials.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: September 17, 1996
    Assignee: BASF Magnetics GmbH
    Inventors: Gregor Brodt, August Lehner, Alfred Lindner, Hermann Graf, Michael Bobrich, Ria Kress, Norbert Schneider, Albert Kohl, Werner Loch
  • Patent number: 5354657
    Abstract: The present invention provides a process for the detection of nucleic acids of definite sequence by hybridisation with two single-stranded nucleic acid probes present in the same solution phase complementary to different regions of the nucleic acid to be detected, one nucleic acid probe serving as detector probe and containing as labelling at least one hapten bound via a chemical linkage and the other nucleic acid probe serving as capturing probe and being bound to a solid matrix, wherein, as hapten, a steroid is used which on at least one position of the detector probe, which does not participate in the hydrogen bridge formation with the nucleic acid to be detected, is covalently bound via a bridge of at least four atoms, the nucleic acid to be detected, present in solution, is incubated with the detector probe and the capturing probe in any desired sequence, whereby the binding of the capturing probe on the matrix with the nucleic acid to be detected is brought about before, during or after the incubation,
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: October 11, 1994
    Inventors: Hans J. Holtke, Rudolf Seibl, Christoph Kessler, Ralf Mattes, Hermann Graf
  • Patent number: 5155164
    Abstract: Products of the condensation of phenolmonosulfonic acids, dihydroxydiphenyl sulfones, urea and formaldehyde can be obtained by(A) preparing a homogeneous reaction mixture in sulfuric acid from the phenolmonosulfonic acid and dihydroxydiphenyl sulfone in the molar ratio of from 3:1 to 10:1, with the proviso that the water content of the mixture is not more than 10% of the total weight of the components, and the mixture contains from 0.3 to 1.5 moles of sulfuric acid per mole of dihydroxydiphenyl sulfone, at from 100.degree. to 180.degree. C.,(B) subsequently, at from 40.degree. to 90.degree. C., carrying out a precondensation with 1 to 2 moles of formaldehyde and 0.5 to 1.5 moles of urea per mole of phenol units present in aqueous medium,(C) partially neutralizing the reaction mixture,(D) adding to the partially neutralized reaction mixture 0 to 0.5 mole of phenol per mole of phenol units present and then 0.1 to 0.8 mole of formaldehyde per mole of phenol units then present,(E) further condensing at from 40.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: October 13, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Hermann Graf, Adolf Stuebinger, Klaus Lorenz, Ortwin Schaffer, Karl Stork
  • Patent number: 4801592
    Abstract: 1,8-Naphthyridine derivatives of the formula ##STR1## where R.sup.1 is alkyl or alkoxyalkyl, R.sup.2 and R.sup.3 are alkyl, R.sup.4 is hydrogen or--alkyl, Z is NHR.sup.5 or NH--NR.sup.6 R.sup.7, R.sup.5 is hydrogen, allyl, benzyl or halobenzyl, and R.sup.6 and R.sup.7 are hydrogen, alkyl, formyl or C.sub.1 -C.sub.4 -alkyl--CO--, and fungicides containing these compounds.
    Type: Grant
    Filed: December 29, 1987
    Date of Patent: January 31, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Hermann Graf, Lothar Franz, Hubert Sauter, Eberhard Ammermann, Ernst-Heinrich Pommer