Abstract: The present disclosure relates to methods and kits for increasing the frequency of insertion of a nucleotide sequence of interest in a specific chromosomal site within the genome of a eukaryotic cell by modifying the state of chromatin in said cell. In the present disclosure chromatin state may be altered by reducing nucleosomal occupancy by modulating the activity of high-mobility group box (HMGB) proteins.

Abstract: The present invention relates to an improved multistep method for the production of an extract of Ginkgo biloba leaves for use as a drug.

Abstract: The present invention relates to an improved multistep method for the production of an extract of Ginkgo biloba leaves for use as a drug.

Abstract: The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Abstract: The present invention relates to extracts from the bark of corynanthe species, in particular corynanthe pachyceras as well as to their use for the therapy and prophylaxis of diseases of the lower urinary tract, sexual disorders, lipid metabolism disorders, cardiovascular diseases and acute and chronic pain conditions. The present invention further relates to medicaments, dietetic food products and pharmaceutical preparations containing these extracts.

Abstract: The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Abstract: The present invention relates to the use of trisubstituted benzopyranones for the treatment or propylaxis of pathological conditions associated with oxidative stress and/or inflammatory reactions as well as to novel trisubstituted benzopyranones and the physiologically acceptable salts thereof. The present invention further relates to plant extracts, medicaments, dietetic food products and pharmaceutical preparations containing these compounds.

Abstract: The present invention relates to a method for preparing an extract from ginkgo biloba having a reduced content of nonpolar plant ingredients and nonpolar impurities due to environmental influences compared to the initial extract, the method being characterized by the following method steps: (a) preparing an aqueous-ketonic or aqueous-alcoholic solution of an initial ginkgo biloba extract and applying the solution to an adsorber resin, (b) eluting the adsorber resin with an aqueous C3-C6 ketone or an aqueous C1-C3 alcohol and (c) optionally concentrating and drying the extract solution thus obtained to the dry extract. The invention further relates to an extract (liquid extract or spissum extract as well as dry extract) from ginkgo biloba having a reduced content of nonpolar plant ingredients and nonpolar impurities due to environmental influences compared to the initial extract, which is obtainable by the method of the present invention.

Abstract: The present invention relates to the use of extracts from roots of Pelargonium sidoides and/or Pelargonium reniforme for the treatment of AIDS and AIDS-associated infections caused by other viruses, bacteria, in particular mycobacteria, fungi and parasites.

Abstract: The present invention relates to an improved multi-step method for preparing an extract from Ginkgo biloba having a reduced content of polycyclic aromatic hydrocarbons. The invention further relates to an extract from Ginkgo biloba having a reduced content of polycyclic aromatic hydrocarbons which is obtainable by the method according to the present invention, as well to its use.

Abstract: The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Abstract: The present invention relates to a method for preparing an extract from Ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones compared to the original extract. The invention further relates to extracts from Ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones compared to the original extract, which is obtainable by the method according to the present invention, as well as to their use.

Abstract: The invention relates to a novel 2H-1-pyran-2-ones of general formula (I), wherein R1 represents an alkyl radical with 2-5 C atoms, a cycloakyl radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkyl radical with a total of 3-5 C atoms and R2 represents a 2-(3, 4-methylene dioxyphenyl) radical or a 2-phenyl ethenyl radical substituted with R3, R4 and R5 in positions 3, 4 and 5, whereby independently from each other R3 and R5 represent methoxy or ethoxy and R4 is a straight chain or branched alkoxy radical with 1-5 C atoms, an alkenyl radical with 3-5 C atoms, a cycloalkoxy radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkoxy radical with a total of 3-5 C atoms. The invention also relates to a method for producing said compunds in addition to novel untermediate products and to a method for the production thereof.

Abstract: Described are 2H-1-benzopyran-2-ones (coumarin derivates) of general formula (I), ##STR1## wherein R.sup.1 is a hydroxyl group, a lower-alkoxy group, a cycloalkoxy group with 4 to 6 C-atoms or the alkyl- or arylsulphonyloxy group R.sup.6 --SO.sub.2 O--;R.sup.2 and R.sup.3, independently of each other, are hydrogen atoms, hydroxyl groups, lower-alkoxy groups or cycloalkoxy groups with 4 to 6 C-atoms;R.sup.4 is a hydrogen atom, a lower-alkyl group with 1 to 4 C-atoms or a phenyl group;Y is a nitrogen atom, a CH group or a COH group;R.sup.5 is a phenyl, naphtyl, pyridinyl or pyrimidinyl group which may optionally be substituted by one or two C.sub.1 -C.sub.5 alkyl groups, by one or two halogen atoms, by a halogen and C.sub.1 -C.sub.5 alkyl together, by perfluoroalkyl with 1 to 3 C-atoms, by C.sub.1 -C.sub.5 alkoxy, by hydroxy, by methylenedioxy or by nitro;R.sup.6 is a lower-alkyl group, a cycloalkyl group with 4 to 6 C-atoms or a phenyl group which may optionally be substituted by one or two C.sub.1 -C.sub.

Abstract: Novel 2H-1-benzopyran-2-ones (coumarin derivatives) of the general formula (I) are provided: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are defined as in the specification, and the addition compounds thereof with physiologically compatible acids, intermediates and methods for the preparation thereof. The coumarin compounds possess a neuroprotective and anti-allergic action.