Patents by Inventor Hermann Oediger
Hermann Oediger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4988820Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O).sub.m R.sup.3, in which R.sup.3 denotes alkyl or aryl, and m denotes one of the numbers 0, 1 or 2, represents a group of the formula ##STR2## in which R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, aryl, aralkyl or acetyl, represents a group of the formula --OR.sup.6, in which R.sup.6 denotes hydrogen, alkyl, aryl, aralkyl, alkyl-SO.sub.2 --, aryl--SO.sub.2 --, aralkyl--SO.sub.2 -- or trifluoromethyl, or represents alkyl, alkenyl or cycloalkyl, each of which is optionally substituted by carboxyl, alkoxycarbonyl, halogen, hydroxyl, alkoxy, alkylthio or cyano, R.sup.Type: GrantFiled: July 20, 1990Date of Patent: January 29, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4965258Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2.Type: GrantFiled: November 28, 1989Date of Patent: October 23, 1990Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4904797Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.Type: GrantFiled: February 8, 1989Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4882353Abstract: For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,R.sup.2 and R.sup.3 are identical or different and stand for hydrogen, alkyl, cycloalkyl or aryl,R.sup.4 stands for hydroxyl, alkoxy, aryloxy, aralkoxy or for a group of the formula --NR.sup.5 R.sup.6, whereR.sup.5 and R.sup.6 are identical or different and in each case denote hydrogen, alkyl, aryl or aralkyl,X denotes a direct bond or an oxygen or sulphur atom, NH or N-alkyl, andn denotes 0 or 1,and their physiologically tolerable salts.Type: GrantFiled: October 26, 1988Date of Patent: November 21, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Hermann Oediger, Ulrich Rosentreter, Horst Boshagen, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4853406Abstract: Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aryl, aralkyl or acyl andX is cyano or carboxyl, and salts thereof. Intermediates therefor of the formula ##STR3## are also new.Type: GrantFiled: May 31, 1988Date of Patent: August 1, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Ulrich Niewohner, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4843091Abstract: An N-sulphonamidoethyl-indole of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, aryl, arylthio, aralkyl, aralkoxy, aralkylthio, acyl or a group of the formula ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl, andR.sup.3 represents hydrogen, alkyl, aryl, pyridyl, thienyl or furyl, andR.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, aryl, aryloxy, arylthio, aralkyl, aralkoxy, aralkylthio, acl or a group of the formula ##STR3## in which R.sup.7 and R.sup.8 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl,R.sup.5 represents hydrogen, ##STR4## or a pharmacologically acceptable salt of ##STR5## and R.sup.2 represents hydrogen, alkyl or aryl.The compounds were R.sup.Type: GrantFiled: June 5, 1987Date of Patent: June 27, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter
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Patent number: 4827032Abstract: Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.Type: GrantFiled: June 29, 1988Date of Patent: May 2, 1989Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4806551Abstract: New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These compounds exhibit a platelet aggregation-inhibiting and thromboxan A.sub.2 -antagonistic action.The N-dihydroindolylethyl-sulphonamides have the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, or represents a group of the formula --S(O).sub.m R.sup.5,whereinR.sup.5 denotes alkyl or aryl andm denotes one of the numbers 0, 1 or 2, orR.sup.1 represents a group of the formula ##STR2## or R.sup.1 represents a group of the formula --OR.sup.8, orR.sup.1 represents optionally substituted alkyl, alkenyl or cycloalkyl,R.sup.2 represents aryl, which is optionally substituted by up to 5 substituents,R.sup.3 represents hydrogenor alkyl andR.sup.4 represents hydrogen, orR.sup.3 and R.sup.4 together bond a carbonyl oxygen.Type: GrantFiled: April 16, 1987Date of Patent: February 21, 1989Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter
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Patent number: 4774240Abstract: The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined in the specification and X is carboxyl, alkoxycarbonyl, cyano or carboxamido. These active compounds are useful in medicaments in combating thromboses, thromboembolisms, allergies or asthmatic disorders.Type: GrantFiled: April 14, 1986Date of Patent: September 27, 1988Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4628062Abstract: New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical,R.sub.2 is hydrogen or a 2-methoxyethoxy or ethoxy radical,R.sub.3 is hydrogen or a sulphamoyl radical, andR.sub.4 is hydrogen,and of the formula ##STR2## in which R.sub.1 is a halogen atom or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.2 is a hydrogen atom, an alkyl radical, a halogen atom, or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.3 and R.sub.4 each independently is hydrogen, alkyl, hydroxyl, alkoxy, sulphonamido or halogen, with the proviso that R.sub.2, R.sub.3 and R.sub.4 are hydrogen when R.sub.1 is hydroxyl,exhibit anti-inflammatory activity.Type: GrantFiled: December 17, 1984Date of Patent: December 9, 1986Assignee: Troponwerke GmbH & Co., KGInventors: Wolfgang Opitz, Bernhard Pelster, Romanis Fruchtmann, Udo Krupka, Walter Gauss, Hartmut Kiehne, Hermann Oediger
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Patent number: 4622339Abstract: Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH.sub.2 --CH.sub.2 -- group, R.sup.1 and R.sup.2 each independently is hydrogen or an alkyl radical with 1-6 carbon atoms,R.sup.3 is alkyl or alkenyl which has 1-8 carbon atoms and is optionally substituted by halogen or alkyl with 1 or 2 carbon atoms, cycloalkyl or cycloalkeny wtih 3 to 7 carbon atoms, an aromatic radical which has 6 or 10 carbon atoms and and is optionally substituted by halogen, by alkyl with 1 or 2 carbon atoms or by halogenoalkyl with 1 or 2 carbon atoms, or is a five-membered or six-membered heteroaromatic radical,R.sup.4 is hydrogen or a hydroxyl group,R.sup.5 and R.sup.6 each independently is hydrogen or alkyl with 1 to 4 carbon atoms, andn is a number from 2 to 6,and, if R.sup.1 is hydrogen, also physiologically acceptable salts thereof, perform as thromboxan antagonists.Type: GrantFiled: January 11, 1985Date of Patent: November 11, 1986Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Hermann Oediger, Hans-Joachim Kabbe, Ulrich Niewohner, Elisabeth Perzborn, Friedel Seuter
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Patent number: 4447367Abstract: The invention relates to phosphonoformaldehyde of the formula ##STR1## Also included in the invention is a method for the manufacture of said phosphonoformaldehyde in which a dialkoxymethane phosphonic acid is warmed with water (then reacted with a base if a salt is desired.) Phosphonoformaldehyde is an intermediate for the manufacture of phosphonohydroxy acetic acid, which is an antiviral agent.Type: GrantFiled: April 22, 1982Date of Patent: May 8, 1984Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
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Patent number: 4397942Abstract: Compounds of the formula ##STR1## are suitable for the stabilization of the latent image in silver halide photographic materials.Type: GrantFiled: October 23, 1981Date of Patent: August 9, 1983Assignee: Agfa-Gevaert AktiengesellschaftInventors: Anita von Konig, Franz Moll, Hermann Oediger
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Patent number: 4370280Abstract: The invention relates to phosphonodroxyacetonitrile and a process for its production which comprises reacting phosphono formaldehyde, in salt form, with hydrocyanic acid (then, if desired, converting the free phosphonohydroxyacetonitrile to salt thereof. The phosphonohydroxyacetonitrile is useful, for example, as an intermediate for the production of phosphonohydroxyacetic acid, an antiviral agent.Type: GrantFiled: October 5, 1981Date of Patent: January 25, 1983Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
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Patent number: 4348332Abstract: The invention relates to phosphonoformaldehyde of the formula ##STR1## Also included in the invention is a method for the manufacture of said phosphonoformaldehyde in which a dialkoxymethane phosphonic acid is warmed with water (then reacted with a base if a salt is desired). Phosphonoformaldehyde is an intermediate for the manufactureof phosphonohydroxy acetic acid, which is an antiviral agent.Type: GrantFiled: October 5, 1981Date of Patent: September 7, 1982Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
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Patent number: 4340599Abstract: The invention relates to phosphono-hydroxyacetic acid and salts thereof of Formula I as defined hereinabove, useful as antiviral agents, e.g. antiherpes agents. Also included in the invention are pharmaceutical compositions and medicaments containing said compounds of Formula I as the active ingredients as well as methods for the use of said compounds, compositions and medicaments.Type: GrantFiled: September 25, 1980Date of Patent: July 20, 1982Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Hermann Oediger, Gert Streible
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Patent number: 4308263Abstract: The invention relates to phosphonoformic acid hydrazide compounds of the formula ##STR1## and salts thereof wherein R represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl radical. The compounds are useful as antiviral agents, particularly against herpes viruses.Also included in the invention are processes for preparing said phosphonoformic acid hydrazide compounds, compositions and medicaments containing said phosphonoformic acid hydrazide compounds and methods for the use of said compounds and compositions.Type: GrantFiled: June 20, 1980Date of Patent: December 29, 1981Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Folker Lieb, Gert Streissle
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Patent number: 4209445Abstract: Process for the preparation of piperonylidenecrotonic acids amides of the formula ##STR1## in which R.sub.1 and R.sub.2 have the meaning given in the disclosure wherein piperonal is reacted with crotonic acid amides of the formula ##STR2## in the presence of hydroxides of the formulaA.sup.+ OH.sup.-in whichA.sup.+ represents a quaternary ammonium or phosphonium group or an alkali metal complex with neutral organic complex ligands,and polar aprotic or polar, sterically hindered protic organic solvents which are inert under the reaction conditions.Type: GrantFiled: December 13, 1978Date of Patent: June 24, 1980Assignee: Haarman & Reimer GmbHInventors: Hermann Oediger, Andreas Schulze
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Patent number: 4209446Abstract: Process for the preparation of piperonylidenecrotonic acid amides of the formula ##STR1## in which R.sub.1 and R.sub.2 have the meaning given in the disclosure wherein piperonal is reacted with crotonic acid amides of the formula ##STR2## in the presence of alkali metal hydroxides and dipolar aprotic diluents which are inert under the reaction conditions.Type: GrantFiled: December 13, 1978Date of Patent: June 24, 1980Assignee: Haarman & Reimer GmbHInventors: Andreas Schulze, Hermann Oediger
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Patent number: 3998857Abstract: Anthraquinones are prepared by reacting a 1,4-naphthoquinone with trans-1-acetoxybutadiene in a polar solvent at a temperature of from 30.degree. to 60.degree. C, optionally in the presence of acetic acid. 1-acetoxy-1,4,4a,9a-tetrahydroanthraquinone is produced which is then treated with oxygen at temperatures of 100.degree. to 130.degree. C without isolation, optionally after adding a salt of acetic acid or a compound which forms an acetic acid salt under the reaction conditions.Type: GrantFiled: July 9, 1975Date of Patent: December 21, 1976Assignee: Bayer AktiengesellschaftInventor: Hermann Oediger