Patents by Inventor Hermann Ulbrich
Hermann Ulbrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8277730Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to, and/or movable away from, a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.Type: GrantFiled: October 12, 2011Date of Patent: October 2, 2012Assignee: Leica Biosystems Nussloch GmbHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel, Janet Minshew
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Publication number: 20120090726Abstract: An apparatus for safety-compliant emptying and filling of a reagent container (24, 40) for a tissue processor (20) comprises a suction line (30, 42) for aspirating a reagent out of the reagent container (24, 40) and a delivery line (32, 44) for filling the reagent container (24, 40) with the reagent, a terminating opening (31, 43) of the suction line (30, 42) being spaced away from a terminating opening (33, 45) of the delivery line (32, 44).Type: ApplicationFiled: October 14, 2011Publication date: April 19, 2012Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Claus HABERKORN, Hermann ULBRICH
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Publication number: 20120052526Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to, and/or movable away from, a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.Type: ApplicationFiled: October 12, 2011Publication date: March 1, 2012Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel, Janet I. Minshew
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Patent number: 8052928Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5). comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). A liquid having a definable property is introducible into a liquid container (7, 11, 13, 15). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that with it, at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to a liquid container (7, 11, 13, 15) and/or movable away from a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) of the tissue infiltration apparatus (1) is definable.Type: GrantFiled: February 15, 2008Date of Patent: November 8, 2011Assignee: Leica Biosystems Nussloch GmbHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel, Janet I. Minshew
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Patent number: 8039262Abstract: A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided including a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a second operating element can be determined. An operator is prompted to confirm unlocking of the closed retort cover by actuating a second operating element. The tissue processing is interrupted when an actuation of the second operating element is determined and the closed retort cover is unlocked and is continued after the retort cover is once again locked. After having completed tissue processing the retort cover is unlocked. By means of the described method and tissue processor improper intervention during ongoing tissue processing is prevented.Type: GrantFiled: August 21, 2009Date of Patent: October 18, 2011Assignee: Leica Biosystems Nussloch GmbHInventors: Marc Konrad, Holger Metzner, Udo Hermann, Frank Meder, Hermann Ulbrich, Markus Dobusch, Stefan Künkel
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Publication number: 20110045565Abstract: A tissue infiltration apparatus, system and method are described, allowing accelerating infiltration of the tissue sample with a variety of reagents fluids. The apparatus comprises a reaction chamber adapted to receive a tissue sample and a dielectric fluid to be infiltrated into a tissue sample. The reaction chamber comprises a bottom and a circumferential wall with a window section that is transparent for microwave irradiation. A holding element holds the tissue sample over a predetermined time period at a distance of 3PD of the dielectric fluid from the window section is provided. PD is the penetration depth of the microwaves into the dielectric fluid and defined as the depth where the initial microwave field intensity has been reduced to 1/e. A microwave system irradiates microwave irradiation through the window section into the reaction chamber.Type: ApplicationFiled: August 18, 2009Publication date: February 24, 2011Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Mark Sanders, Hermann Ulbrich
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Publication number: 20110041599Abstract: A method for operating a tissue processor is described. During the operation of a tissue processor a reagent is fed from a container into a retort of the tissue processor, which retort does not contain any tissue samples. Thereafter, the reagent is returned into the container. During feeding, returning and/or in between feeding and returning a measured value is detected by a sensor of the tissue processor. This value is representative of a concentration of the reagent. During this feeding, this returning and/or in between no tissue sample is placed in the retort.Type: ApplicationFiled: August 18, 2010Publication date: February 24, 2011Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Udo Herrmann, Hermann Ulbrich
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Publication number: 20100323395Abstract: In the automatic processing of tissue samples in a tissue processor, the tissue samples are placed in a retort of the tissue processor. The tissue samples are exposed to a fixation reagent (FIX) in the retort. Afterwards, the tissue samples are exposed to a dehydrating reagent (ALK). Thereafter, the retort is cleared with an intermedium (INT) for removing the dehydrating reagent (ALK). Finally, the tissue samples are treated with a carrier material (CAR). Between the clearing of the retort with the intermedium (INT) and the treatment of the tissue samples with the carrier material (CAR), the retort is cleared with a carrier material protecting reagent (CARPRO) in which the intermedium (INT) and the carrier material (CAR) can be mixed.Type: ApplicationFiled: May 27, 2010Publication date: December 23, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann ULBRICH, Stefan KÜNKEL
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Publication number: 20100263390Abstract: A freezing microtome for the production of microscopable thin sections of tissue samples (60), comprising a cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) for freezing the tissue samples (60), a cutting device for cutting the frozen tissue samples (60) and a working chamber, in which the cutting device and at least a part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) are arranged is described. The part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) arranged in the working chamber contains a liquid coolant (70), in which the tissue samples (60) can be inserted for freezing.Type: ApplicationFiled: April 16, 2010Publication date: October 21, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Uwe HÖFLING, Hermann ULBRICH, Ralf ECKERT, Michael EBERHARD
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Publication number: 20100248301Abstract: The present invention relates to a tissue embedding apparatus (1) for automatic embedding of at least one tissue sample (8). The tissue embedding apparatus (1) encompasses an input unit (2), an image acquisition unit (3), an embedding unit (4), at least one output unit (5, 6), and a control unit (7). A cassette (9) containing at least one tissue sample (8) is transferable to the input unit (2) of the tissue embedding apparatus (1). The tissue sample (8) is embeddable in an embedding medium by means of the embedding unit (4). The embedded tissue sample is outputtable with the at least one output unit (5). At least one image of the tissue sample (8) is acquirable with the image acquisition unit (3).Type: ApplicationFiled: April 23, 2008Publication date: September 30, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel
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Publication number: 20100216222Abstract: The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can be filled into a liquid container (7, 11a-11d, 13, 15). A plurality of cassettes (5) can be held by a transport device (4). Using the transport apparatus (6), a transport device (4) can be brought to a liquid container (7, 11a-11d, 13, 15) and/or moved away from a liquid container (7, 11a-11d, 13, 15). A sequence of operations (8) can be prescribed in which a transport device (4) runs through the liquid containers (7, 11a-11d, 13, 15) of the tissue infiltration device (1).Type: ApplicationFiled: September 16, 2008Publication date: August 26, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann Ulbrich, Marc Konrad, Peter Richter
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Publication number: 20100112624Abstract: A method for operating a tissue processor and a respective tissue processor for performing this method are described for the processing tissue samples. The tissue processor comprises at least one retort for receiving the tissue samples and at least one container for receiving a process medium. The process medium is transferred at least one of from the container into the retort and from the retort into the container. A value is automatically measured in the course of transferring the process medium, the value representing a characteristic property of the process medium. The process medium is identified based on the value.Type: ApplicationFiled: October 27, 2009Publication date: May 6, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Holger Metzner, Udo Herrmann, Hermann Ulbrich, Eva Goedecke
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Publication number: 20100055788Abstract: A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first and second containers carrier materials of differing degrees of purity are kept ready for use, respectively, for performing various infiltration steps on tissue samples. By means of the described method and apparatus the tissue processor can be operated with as little interruptions as possible and an ease in operation is achieved.Type: ApplicationFiled: August 17, 2009Publication date: March 4, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann Ulbrich, Michael Rapp, Marc Konrad, Holger Metzner, Markus Dobusch, Eve Goedecke, Stefan Kuenkel, Udo Herrmann
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Publication number: 20100055663Abstract: A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided comprising a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a second operating element can be determined. An operator is prompted to confirm unlocking of the closed retort cover by actuating a second operating element. The tissue processing is interrupted when an actuation of the second operating element is determined and the closed retort cover is unlocked and is continued after the retort cover is once again locked. After having completed tissue processing the retort cover is unlocked. By means of the described method and tissue processor improper intervention during ongoing tissue processing is prevented.Type: ApplicationFiled: August 21, 2009Publication date: March 4, 2010Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Marc Konrad, Holger Metzner, Udo Hermann, Frank Meder, Hermann Ulbrich, Markus Dobusch, Stefan Künkel
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Publication number: 20080199955Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5). comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). A liquid having a definable property is introducible into a liquid container (7, 11, 13, 15). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that with it, at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to a liquid container (7, 11, 13, 15) and/or movable away from a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) of the tissue infiltration apparatus (1) is definable.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Kunkel, Janet I. Minshew
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Patent number: 3965103Abstract: Compounds of the formula v,2/12Wherein R.sub.1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH.sub.2) .sub.n --X wherein n is 0-4 and X is --COO-lower-alkyl, C.tbd.N or --COOH and R.sub.2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula ##SPC1##With a nitro compound of the formula R.sub.1 --CH.sub.2 --NO.sub.2 in the presence of formalin or paraformaldehyde, or with the R.sub.1 -- C(CH.sub.2 OH).sub.2 NO.sub.2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.Type: GrantFiled: September 20, 1974Date of Patent: June 22, 1976Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Hermann Ulbrich, Hans-Joachim Kessler, Ulrich Redmann
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Patent number: 3937733Abstract: Salts of iodomethanesulfonic acid and an organic base, more particularly, glucamine, N-alkyl- and N, N-dialkylglucamines and N-hydroxyalkyl- and N,N-di-hydroxyalkylglucamines, are useful as X-ray contrast agents, especially for spinal X-ray examination.Type: GrantFiled: March 31, 1972Date of Patent: February 10, 1976Assignee: Schering AktiengesellschaftInventors: Hermann Ulbrich, Wolfgang Beich