Abstract: The present invention relates to treatment and diagnosis of lung cancer and metastases thereof. More specifically, the invention relates to such therapeutic use of antigen sources providing immunogenic polypeptides comprising at least an immunogenic portion of a cancer cell associated protein, which preferably is a zona pellucida (ZP) protein, especially a ZP3 protein or the extracellular domain thereof, whereby the antigen source induces a cellular immune response against the lung cancer cells. The antigen source can be a proteinaceous composition comprising such immunogenic ZP polypeptide, a nucleic acid encoding the immunogenic ZP polypeptide, or a cell expressing or presenting the immunogenic ZP polypeptide. In addition, the invention relates to the therapeutic use of a T cell comprising a T cell receptor that binds an MHC-peptide complex, wherein the peptide is a peptide from the immunogenic ZP polypeptide.

Abstract: Method for determining a kisspoint of a clutch. A method is provided of determining a kisspoint of a clutch in a driveline of a vehicle comprising a. increasing a target clutch pressure of a clutch piston up to a first predetermined test target pressure, b. increasing the target clutch pressure up to an upper target pressure and subsequently keeping the target clutch pressure stable for a predetermined time interval, c. monitoring a parameter indicative for the filling of the clutch piston, e.g. the rotational speed of a pump, during the predetermined time interval, d. repeating steps a., b., and c. for at least one further predetermined test target pressure, and e. determining the kisspoint based on the monitored parameter indicative for the filling of the clutch piston.

Abstract: An inkjet printing apparatus for printing on a substrate, such as a flexible packaging material, includes at least three inkjet heads including a first inkjet head, a second inkjet head, and at least one further inkjet head. At least one drying unit includes a first drying unit arranged opposite a first drying location which is located between the first and second inkjet location, the first drying unit being configured for physically removing liquid from ink applied by the first inkjet head. At least a first drum and a second drum, where the first and second inkjet locations as well as the first drying location are located on an outer surface of the first drum; and the at least one further inkjet location is located on an outer surface of the second drum.

Abstract: Disclosed herein is a connector for electrically connecting a feedthrough of a vacuum tool to a high voltage power source, the connector comprising: a connector wire assembly configured to be in electrical connection with a high voltage power source; and a connector insulator comprising a channel configured to extend into the connector insulator and to receive a feedthrough pin so as to electrically connect the connector wire assembly with the feedthrough pin; wherein the connector insulator is configured to engage with the feedthrough so that a boundary surface of the connector insulator extends substantially bi-directionally in the direction of the longitudinal axis of the channel.

Abstract: Method for determining a kisspoint of a clutch. A method is provided of determining a kisspoint of a clutch in a driveline of a vehicle comprising a. increasing a target clutch pressure of a clutch piston up to a first predetermined test target pressure, b. increasing the target clutch pressure up to an upper target pressure and subsequently keeping the target clutch pressure stable for a predetermined time interval, c. monitoring a parameter indicative for the filling of the clutch piston, e.g. the rotational speed of a pump, during the predetermined time interval, d. repeating steps a., b., and c. for at least one further predetermined test target pressure, and e. determining the kisspoint based on the monitored parameter indicative for the filling of the clutch piston.

Abstract: Disclosed herein is an aperture body for passing a portion of a charged particle beam propagating along a beam path comprising an axis, the aperture body comprising: an up-beam facing surface; a chamber portion comprising an up-beam end, a down-beam end and an up-beam plate, wherein the up-beam plate extends radially inwards from the up-beam end and the up-beam plate is configured to define an entrance opening around the beam path; wherein: the up-beam facing surface extends radially inwards from the down-beam end; the up-beam facing surface comprises an aperture portion that is configured to define an opening around the beam path; and the opening defined by the aperture portion is smaller than the entrance opening.

Abstract: A thermal energy storage system is provided, comprising an outer shell defining an outer shell volume, an energy transfer module, comprising an input port for providing energy to the energy storage system, an output port for retrieving energy from energy storage system, wherein the outer shell is provided with a fluid distribution network.

Abstract: The application relates to an enzyme composition, a process for the preparation thereof and the use of the enzyme composition in enzymatic hydrolysis.

Abstract: The invention relates to a process for producing a fermentation broth by culturing a microorganism.

Abstract: The present invention relates to a new use of tetrahydroxylated estrogens such as estetrol (1,3,5(10)-estratrien-3, 15?, 16?, 17?-tetrol), namely in a method of emergency contraception. The method of emergency contraception according to the invention comprises the oral administration of estetrol in a single dose within 120 hours of sexual intercourse.

Abstract: An inkjet printing apparatus for printing on a substrate, such as a flexible packaging material, includes at least three inkjet heads including a first inkjet head, a second inkjet head, and at least one further inkjet head. At least one drying unit includes a first drying unit arranged opposite a first drying location which is located between the first and second inkjet location, the first drying unit being configured for physically removing liquid from ink applied by the first inkjet head. At least a first drum and a second drum, where the first and second inkjet locations as well as the first drying location are located on an outer surface of the first drum; and the at least one further inkjet location is located on an outer surface of the second drum.

Abstract: The application relates to an enzyme composition, a process for the preparation thereof and the use of the enzyme composition in enzymatic hydrolysis.

Abstract: The invention relates to the treatment of advanced estrogen receptor positive breast cancer in a subject who has been treated with an estrogen activity suppressor selected from a selective estrogen receptor modulator (SERM), an aromatase inhibitor and an anti-estrogen, said treatment comprising administration of an estriol component after the treatment with an estrogen activity suppressor has been discontinued, said estriol component being selected from estriol, prodrugs of estriol and combinations thereof.

Abstract: The invention relates to the treatment of advanced estrogen receptor positive breast cancer in a subject who has been treated with an estrogen activity suppressor selected from a selective estrogen receptor modulator (SERM), an aromatase inhibitor and an anti-estrogen, said treatment comprising administration of an estetrol component after the treatment with an estrogen activity suppressor has been discontinued, said estetrol component being selected from estetrol, prodrugs of estetrol and combinations thereof.

Abstract: The present invention relates to a method based on the use of restriction enzyme digestion and ligation via the cleavage sites, thereby to prepare two or more standardized expression cassettes.

Abstract: The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 17?-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is —Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is —Si(R2)3.

Abstract: A method for curing of an actinic light sensitive ink or toner layer on a substrate includes irradiating the actinic light sensitive ink or toner layer with a first radiation dose D1 in a first spectral range between 320 nm and 445 nm, followed by a second radiation dose D2 in a second spectral range between 200 nm and 319 nm. The ratio D1/D2 of the first radiation dose and the second radiation dose is between 0.25 and 500, more preferably between 0.25 and 200, even more preferably between 0.50 and 100.

Abstract: The present invention relates to treatment and diagnosis of lung cancer and metastases thereof. More specifically, the invention relates to such therapeutic use of antigen sources providing immunogenic polypeptides comprising at least an immunogenic portion of a cancer cell associated protein, which preferably is a zona pellucida (ZP) protein, especially a ZP3 protein or the extracellular domain thereof, whereby the antigen source induces a cellular immune response against the lung cancer cells. The antigen source can be a proteinaceous composition comprising such immunogenic ZP polypeptide, a nucleic acid encoding the immunogenic ZP polypeptide, or a cell expressing or presenting the immunogenic ZP polypeptide. In addition, the invention relates to the therapeutic use of a T cell comprising a T cell receptor that binds an MHC-peptide complex, wherein the peptide is a peptide from the immunogenic ZP polypeptide.

Abstract: The present disclosure pertains to a system configured to predict decompensation in a subject with heart failure. The system comprises one or more hardware processors configured by machine-readable instructions to receive weight information, blood pressure information, and heart rate information about the subject; determine one or more weight parameters, one or more blood pressure parameters, and one or more heart rate parameters based on the received information; and predict decompensation in the subject based on the one or more weight parameters, the one or more blood pressure parameters, and the one or more heart rate parameters. Prior art systems use weight parameters alone for such prediction. However, weight parameters alone are often not predictive of decompensation.

Abstract: A method for curing of an actinic light sensitive ink or toner layer on a substrate includes irradiating the actinic light sensitive ink or toner layer with a first radiation dose D1 in a first spectral range between 320 nm and 445 nm, followed by a second radiation dose D2 in a second spectral range between 200 nm and 319 nm. The ratio D1/D2 of the first radiation dose and the second radiation dose is between 0.25 and 500, more preferably between 0.25 and 200, even more preferably between 0.50 and 100.