Patents by Inventor Hermanus C. C. K. Van Bakel

Hermanus C. C. K. Van Bakel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analgesic 9,9-dimethylbenzomorphanes
    Patent number: 4473576
    Abstract: 9,9-Dimethyl-6,7-benzomorphan derivatives having an oxygen-containing substituent on the nitrogen atom, optionally an alkyl or phenyl 5-substituent and optionally a hydroxy, alkoxy or acyloxy 2'-substituent have analgetic and/or morphine-antagonist properties.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: September 25, 1984
    Assignee: ACF Chemiefarma NV
    Inventors: Antony M. Akkerman, Hermanus C. C. K. van Bakel
  • Analgesic 5-oxygenated-6,7-benzomorphan derivatives
    Patent number: 4425353
    Abstract: 6,7-Benzomorphan derivatives of formula I, ##STR1## wherein R.sub.1 is hydrogen; optionally hydroxy- and/or alkoxy-substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl; alkenyloxyalkyl, aralkyl, arylhydroxyalkyl, aralkenyl or tetrahydrofurylalkyl; or optionally alkyl-substituted furylalkyl or isoxazolylalkyl, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, hydroxyalkyl of alkoxyalkyl and R.sub.4 is hydrogen, hydroxy, alkoxy or alkenyloxy, hydroxy groups in said compounds being each optionally acylated, having analgesic and luteinising hormone secretion inhibiting properties.
    Type: Grant
    Filed: July 13, 1981
    Date of Patent: January 10, 1984
    Assignee: ACF Chemiefarma NV
    Inventors: Antony M. Akkerman, Hermanus C. C. K. van Bakel, Roelof C. K. Smit
  • Analgesic and morphine-antagonistic 6,7-benzomorphans
    Patent number: 4288444
    Abstract: The invention is concerned with certain new 6,7-benzomorphan derivatives having pharmacological, in particular analgesic and/or morphine-antagonistic properties, of the formula ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl or heteroaryl group; R.sup.2 is a hydrogen or halogen atom, or a hydroxy, alkoxy or acyloxy group; R.sup.3 is an alkyl or alkenyl group; R.sup.4 is a hydrogen atom or a hydroxy, alkoxy or acyloxy group; and R.sup.5 is an alkyl group or, when R.sup.2 is hydrogen in a trans-position to R.sup.3, R.sup.5 is a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, or a substituted or unsubstituted phenylalkyl, heteroarylalkyl or heterocycloalkylalkyl group; optical isomers and pharmaceutically acceptable salts thereof.The preferred compound is the .alpha.-isomer of 2,5-dimethyl-2'-hydroxy-9-phenyl-6,7-benzomorphan, in particular its (+)-enantiomer.
    Type: Grant
    Filed: April 25, 1980
    Date of Patent: September 8, 1981
    Assignee: ACF Chemiefarma N.V.
    Inventors: Antony M. Akkerman, Hermanus C. C. K. van Bakel, Henriette G. Van Breevoort-Uurbanus
  • Analgesic and morphine-antagonistic 9-phenyl-6,7-benzomorphans
    Patent number: 4234591
    Abstract: The invention is concerned with certain new 6,7-benzomorphan derivatives having pharmacological, in particular analgesic and/or morphine-antagonistic properties, of the formula ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl or heteroaryl group; R.sup.2 is a hydrogen or halogen atom, or a hydroxy, alkoxy or acyloxy group; R.sup.3 is an alkyl or alkenyl group; R.sup.4 is a hydrogen atom or a hydroxy, alkoxy or acyloxy group; and R.sup.5 is an alkyl group or, when R.sup.2 is hydrogen in a trans-position to R.sup.3, R.sup.5 is a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, or a substituted or unsubstituted phenylalkyl, heteroarylalkyl or heterocycloalkylalkyl group; optical isomers and pharmaceutically acceptable sals thereof.The preferred compound is the .alpha.-isomer of 2,5-dimethyl- 2'-hydroxy-9-phenyl-6,7-benzomorphan, in particular its (+)-enantiomer.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: November 18, 1980
    Assignee: ACF Chemiefarma N.V.
    Inventors: Antony M. Akkerman, Hermanus C. C. K. Van Bakel, Henriette G. van Breevoort-Uurbanus