Patents by Inventor Hermanus Carolus Catherina Karel Bakel Van

Hermanus Carolus Catherina Karel Bakel Van has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of dioxane acetic acid esters
    Patent number: 7442811
    Abstract: Process for the preparation of an ester of formula (1), wherein R1 represents a leaving group, CN, OH or a COOR5 group, R3 and R4 each independently represent a 1-3 C alkyl group, and R2 and R5 each independently represent an ester residue, wherein the corresponding salt with formula (2), wherein M represents H or an alkali (earth) metal in an inert solvent is contacted with an acid chloride forming agent to form the corresponding acid chloride, and the acid chloride is contacted with an alcohol with formula R2OH in the presence of N-methyl-morpholine. Preferably M represents an alkali metal, and R2 represents an alkyl group, particularly a t.-butyl group.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: October 28, 2008
    Assignee: AstraZeneca UK Limited
    Inventors: Hermanus Carolus Catherina Karel Bakel Van, Dominique Monique Charles Callant, Jacob Hermanus Mattheus Hero Kooistra, Peter Johannes Dominicus Maas