Patents by Inventor Hermanus J. M. Kempen

Hermanus J. M. Kempen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
    Patent number: 4751219
    Abstract: Synthetic glycolipides having the general formula lipidyl-O-R wherein the lipidyl moiety is selected from the group consisting of 5-cholestene-3.beta.-yl, ceramidyl, phosphatidylethanolamine and diacylglycerol and R represents a group having the formula ##STR1## in which two symbols Z represent a glycopyranosyl rest and the other symbol Z a hydrogen atom or all three symbols Z represent a glycopyranosyl rest. These new glycolipides can be used for the solubilization of cholesterol in water or aqueous media, for the manufacture of lipide-vesicles or lipoproteins in which such a glycolipide is encapsulated as well as for the reduction of the cholesterol level in the blood plasma of mammals. Preferably the compound N-tris(.beta.-D-galactopyranosyloxymethyl)methyl-N.alpha.-(4-(5 cholesten-3.beta.-yloxy)succinyl)glycinamide is used.
    Type: Grant
    Filed: February 5, 1985
    Date of Patent: June 14, 1988
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek
    Inventor: Hermanus J. M. Kempen
  • Binder for low density lipoproteins
    Patent number: 4647280
    Abstract: A binder for low density lipoproteins (LDL) consisting of sulphated polyvinyl alcohol which is cross-linked by the chemical or the physical route to a waterinsoluble product. The binder may be in the form of a hydrogel which is applied or not to a carrier or it may be present on the surface of a polyvinyl alcohol fibre which is preferably in the form of tape having a thickness of 0,1 to 2 .mu.m and a width of 0,5 to 6 .mu.m. The fibre shaped binder is prepared by successively cross-linking with an acidified aqueous solution of glutardialdehyde and sulphating with chlorosulphonic acid.
    Type: Grant
    Filed: July 2, 1986
    Date of Patent: March 3, 1987
    Assignee: Akzo nv
    Inventors: Nico Maaskant, Adriaan Bantjes, Hermanus J. M. Kempen
  • Binder for low density lipoproteins
    Patent number: 4623628
    Abstract: A binder for low density lipoproteins (LDL) consisting of sulphated polyvinyl alcohol which is cross-linked by the chemical or the physical route to a waterinsoluble product. The binder may be in the form of a hydrogel which is applied or not to a carrier or it may be present on the surface of a polyvinyl alcohol fibre which is preferably in the form of tape having a thickness of 0.1 to 2 .mu.m and a width of 0.5 to 6 .mu.m. The fibre shaped binder is prepared by successively cross-linking with an acidified aqueous solution of glutardialdehyde and sulphating with chlorosulphonic acid.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: November 18, 1986
    Assignee: Organon Teknika b.v.
    Inventors: Nico Maaskant, Adriaan Bantjes, Hermanus J. M. Kempen