Patents by Inventor Hernan A. Navarro

Hernan A. Navarro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kappa opioid receptor ligands
    Patent number: 7872023
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: January 18, 2011
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • KAPPA OPIOID RECEPTOR LIGANDS
    Publication number: 20090264462
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 22, 2009
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, James B. Thomas, Tingwei Cai
  • Octahydroisoquinoline compounds as opioid receptor modulators
    Patent number: 7476679
    Abstract: Compounds which bind to opioid receptors are provided. In a preferred embodiment of the invention, the compounds are opioid receptor antagonists. The present invention also provides methods of treating conditions which are mediated by an opioid receptor.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: January 13, 2009
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A Navarro, S. Wayne Mascarella, James B. Thomas
  • Opioid receptor agonist compounds and their use in treatment of pain
    Patent number: 7399762
    Abstract: Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: July 15, 2008
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro
  • Octahydroisoquinoline compounds as opioid receptor modulators
    Publication number: 20070027182
    Abstract: Compounds which bind to opioid receptors are provided. In a preferred embodiment of the invention, the compounds are opioid receptor antagonists. The present invention also provides methods of treating conditions which are mediated by an opioid receptor.
    Type: Application
    Filed: July 26, 2005
    Publication date: February 1, 2007
    Applicant: Research Triangle Institute
    Inventors: Frank Carroll, Hernan Navarro, S. Mascarella, James Thomas
  • Opiod receptor agonist compounds and their use in treatment of pain
    Publication number: 20060241135
    Abstract: Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
    Type: Application
    Filed: April 25, 2005
    Publication date: October 26, 2006
    Applicant: Research Triangle Institute
    Inventors: Frank Carroll, Hernan Navarro
  • Kappa opioid receptor ligands
    Publication number: 20060183743
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 17, 2006
    Applicant: Research Triangle Institute
    Inventors: Carroll Frank, Hernan Navarro, Lawrence Brieaddy, Scott Runyon
  • Ligands for &agr;-7 nicotinic acetylcholine receptors based on methyllcaconitine
    Patent number: 6416735
    Abstract: Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimer's and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: July 9, 2002
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernán A. Navarro, Philip Abraham, Desong Zhong