Patents by Inventor Hernan Jara
Hernan Jara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11375918Abstract: Methods of characterizing the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) generating a spatial entropy map of the brain of the subject from the plurality of magnetic resonance images; and/or generating a myelin water map of the brain of the subject from the plurality of magnetic resonance images.Type: GrantFiled: November 25, 2020Date of Patent: July 5, 2022Assignees: Boston Medical Center Corporation, Trustees of Boston UniversityInventors: Hernan Jara, Ryan McNaughton
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Publication number: 20210082113Abstract: Methods of characterizing the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) generating a spatial entropy map of the brain of the subject from the plurality of magnetic resonance images; and/or generating a myelin water map of the brain of the subject from the plurality of magnetic resonance images.Type: ApplicationFiled: November 25, 2020Publication date: March 18, 2021Inventors: Hernan JARA, Ryan McNaughton
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Patent number: 10575753Abstract: Methods of making a white matter fibrogram representing the connectome of the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) rendering a white matter fibrogram of the brain of the subject from the plurality of magnetic resonance images.Type: GrantFiled: May 30, 2019Date of Patent: March 3, 2020Assignee: BOSTON MEDICAL CENTER CORPORATIONInventor: Hernan Jara
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Publication number: 20190365273Abstract: Methods of making a white matter fibrogram representing the connectome of the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) rendering a white matter fibrogram of the brain of the subject from the plurality of magnetic resonance images.Type: ApplicationFiled: May 30, 2019Publication date: December 5, 2019Inventor: Hernan JARA
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Patent number: 10114095Abstract: Methods, and systems and apparatus for implementing the methods, are described for performing efficient multispectral magnetic resonance imaging, such that images of multiple contrast weightings for each slice are acquired in a single scan. Such differentially weighted MR images are thus suitable for generating a plurality of coregistered parameter maps for each slice. The methods may comprise applying a first excitation pulse to a first slice of a subject; detecting a first plurality of echo signals emitted by the first slice after the first excitation pulse; waiting a first period of time; applying a second excitation pulse to the first slice during partial recovery of a longitudinal magnetization of the first slice; and detecting a second plurality of echo signals emitted by the first slice after the second excitation pulse.Type: GrantFiled: August 26, 2014Date of Patent: October 30, 2018Assignee: BOSTON MEDICAL CENTER CORPORATIONInventor: Hernan Jara
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Patent number: 9920389Abstract: Methods and systems are disclosed for the hydrolysis of mixed biomass. The methods include forming a mixture of at least two modified biomass feedstocks to achieve various benefits, such as maximizing sugar yields and minimizing the formation of degradation products.Type: GrantFiled: October 26, 2015Date of Patent: March 20, 2018Assignee: Renmatix, Inc.Inventors: Manuk Colakyan, Rory Hernan Jara-Moreno
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Publication number: 20170089997Abstract: In a first aspect this invention provides methods comprising administering an aqueous contrast agent to the vascular system of a subject, and performing a magnetic resonance scan to detect the MR signal enhancement effects of the aqueous contrast agent. In embodiments the magnetic resonance scan comprises applying at least one pulse sequence selected from a PD-weighted pulse sequence, a T1-weighted pulse sequence, a T2-weighted pulse sequence, and a D-weighted pulse sequence. In embodiments the magnetic resonance scan comprises applying a T1-weighted pulse sequence. A system for performing perfusion MRI comprising an aqueous contrast solution and an injection apparatus configured to provide a maximum injection rate of the aqueous contrast solution to a subject vascular system of at least about 5 ml/s. is also provided.Type: ApplicationFiled: May 14, 2015Publication date: March 30, 2017Applicant: BOSTON MEDICAL CENTER CORPORATIONInventors: Hernan JARA, Asim MIAN, Stephan ANDERSON, Osamu SAKAI, Alex NORBASH, Jorge SOTO
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Publication number: 20160291109Abstract: Methods, and systems and apparatus for implementing the methods, are described for performing efficient multispectral magnetic resonance imaging, such that images of multiple contrast weightings for each slice are acquired in a single scan. Such differentially weighted MR images are thus suitable for generating a plurality of coregistered parameter maps for each slice. The methods may comprise applying a first excitation pulse to a first slice of a subject; detecting a first plurality of echo signals emitted by the first slice after the first excitation pulse; waiting a first period of time; applying a second excitation pulse to the first slice during partial recovery of a longitudinal magnetization of the first slice; and detecting a second plurality of echo signals emitted by the first slice after the second excitation pulse.Type: ApplicationFiled: August 26, 2014Publication date: October 6, 2016Applicant: Boston Medical Center CorporationInventor: Hernan JARA
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Publication number: 20160040259Abstract: Methods and systems are disclosed for the hydrolysis of mixed biomass. The methods include forming a mixture of at least two modified biomass feedstocks to achieve various benefits, such as maximizing sugar yields and minimizing the formation of degradation products.Type: ApplicationFiled: October 26, 2015Publication date: February 11, 2016Inventors: Manuk Colakyan, Rory Hernan Jara-Moreno
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Patent number: 9200337Abstract: Methods and systems are disclosed for the hydrolysis of mixed biomass. The methods include forming a mixture of at least two modified biomass feedstocks to achieve various benefits, such as maximizing sugar yields and minimizing the formation of degradation products.Type: GrantFiled: April 22, 2014Date of Patent: December 1, 2015Assignee: Renmatix, Inc.Inventors: Manuk Colakyan, Rory Hernan Jara-Moreno
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Publication number: 20150299816Abstract: Methods and systems are disclosed for the hydrolysis of mixed biomass. The methods include forming a mixture of at least two modified biomass feedstocks to achieve various benefits, such as maximizing sugar yields and minimizing the formation of degradation products.Type: ApplicationFiled: April 22, 2014Publication date: October 22, 2015Applicant: Renmatix, Inc.Inventors: Manuk Colakyan, Rory Hernan Jara-Moreno
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Synthetic images for a magnetic resonance imaging scanner using linear combinations of source images
Patent number: 7002345Abstract: The invention consists of three image-postprocessing phases for the purposes of generating high-quality quantitative MR images (proton density (PD), T1, and T2) as well as high-quality virtual MR images with continuously adjustable computer-synthesized contrast weightings, from source images acquired directly with an MRI scanner. Each of the image-postprocessing phases uses one or several new computer algorithms that improve image quality with respect to prior art, including linear-combination-of source-images (LCSI) algorithms for generating PD images and model-conforming algorithms for generating Q-MR images of tissue properties that influence NMR relaxation.Type: GrantFiled: March 5, 2004Date of Patent: February 21, 2006Assignee: Boston Medical Center CorporationInventor: Hernan Jara -
Patent number: 6917199Abstract: The invention consists of three image-postprocessing phases for the purposes of generating high-quality quantitative MR images (proton density (PD), T1, and T2) as well as high-quality virtual MR images with continuously adjustable computer-synthesized contrast weightings, from source images acquired directly with an MRI scanner. Each of the image-postprocessing phases uses one or several new computer algorithms that improve image quality with respect to prior art, including linear-combination-of source-images (LCSI) algorithms for generating PD images and model-conforming algorithms for generating Q-MR images of tissue properties that influence NMR relaxation.Type: GrantFiled: March 5, 2004Date of Patent: July 12, 2005Assignee: Boston Medical Center CorporationInventor: Hernan Jara
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Patent number: 6823205Abstract: The invention consists of three image-postprocessing phases for the purposes of generating high-quality quantitative MR images (proton density (PD), T1, and T2) as well as high-quality virtual MR images with continuously adjustable computer-synthesized contrast weightings, from source images acquired directly with an MRI scanner. Each of the image-postprocessing phases uses one or several new computer algorithms that improve image quality with respect to prior art, including linear-combination-of source-images (LCSI) algorithms for generating PD images and model-conforming algorithms for generating Q-MR images of tissue properties that influence NMR relaxation.Type: GrantFiled: February 8, 2001Date of Patent: November 23, 2004Assignee: Boston University Radiology AssociatesInventor: Hernan Jara
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Publication number: 20040227514Abstract: The invention consists of three image-postprocessing phases for the purposes of generating high-quality quantitative MR images (proton density (PD), T1, and T2) as well as high-quality virtual MR images with continuously adjustable computer-synthesized contrast weightings, from source images acquired directly with an MRI scanner. Each of the image-postprocessing phases uses one or several new computer algorithms that improve image quality with respect to prior art, including linear-combination-of source-images (LCSI) algorithms for generating PD images and model-conforming algorithms for generating Q-MR images of tissue properties that influence NMR relaxation.Type: ApplicationFiled: March 5, 2004Publication date: November 18, 2004Inventor: Hernan Jara
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Publication number: 20040169512Abstract: The invention consists of three image-postprocessing phases for the purposes of generating high-quality quantitative MR images (proton density (PD), T1, and T2) as well as high-quality virtual MR images with continuously adjustable computer-synthesized contrast weightings, from source images acquired directly with an MRI scanner. Each of the image-postprocessing phases uses one or several new computer algorithms that improve image quality with respect to prior art, including linear-combination-of source-images (LCSI) algorithms for generating PD images and model-conforming algorithms for generating Q-MR images of tissue properties that influence NMR relaxation.Type: ApplicationFiled: March 5, 2004Publication date: September 2, 2004Inventor: Hernan Jara