Abstract: Disclosed is an enabling process for high throughput manufacturing of large variety of chemical and biological sensors that utilize well-developed spin-based sensing of analyte binding. A method for producing a nanometer scale analyte specific sensor may be provided, that includes providing a first material (such as a diamond) having a luminescent center (such as an NV center) within predetermined distance (such as 2-5 nm) of a first surface, where the luminescent center configured to emit within an optical emission range, providing photochemically active molecules (such as molecules with a photo-uncaging protective group) where an optical absorption range of the photochemically active molecules at least partially overlaps the optical emission range, coating the first surface of the first material with the photochemically active molecules, and may include placement of the photochemically active surface molecule within a distance smaller than the Forster Resonant Excitation Transfer (i.e.

Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.

Abstract: Systems and methods are described, and one system includes a three-dimensional (3D) geometric tracker connected to a multiband (MB) inverse synthetic aperture array radar (ISAR), and a classification/alarm logic. The MB ISAR includes spatially distributed radar transmitters (TXs) and receivers (RXs), a TX/RX allocation logic, and a tomographic (TM) image logic. The TX/RX allocation logic is configured to receive 3D tracking data from the 3D geometric tracker, indicating subject 3D position and 3D orientation and, in response, dynamically allocate TXs and RXs to maintain MB illumination of and maintain MB reception of multiple scatter angles from subjects. The TM image processor is configured to construct TM images from the scatter angles, using 3D tracking data, for input to the classification and alarm logic. Optionally, the TX/RX resource allocation logic is configured to receive situation feedback data, for feedback adjusting of allocation of TXs and RXs.

Abstract: Disclosed herein is the detection of dangerous dielectric materials (explosives) and dangerous non-explosive and/or prohibited items. The detection is based on a broad bandwidth nonlinear radar system, driven by a highly stable optical frequency comb. The disclosed approach allows for the spatial resolution of the interrogated object in complex settings. Detection of dangerous materials and non-explosive chemical prohibited items is disclosed.

Abstract: Disclosed is a system and method for shaped incoherent light for control (SILC). More particularly, disclosed is a method for controlling the evolution of photo-responsive systems (including chemical species, biochemical species or material compounds) using a device capable of producing shaped incoherent light for such control. The disclosed device integrates a polychromatic incoherent source in an adaptive feedback control loop.

Abstract: Disclosed is a system and method for shaped incoherent light for control (SILC). More particularly, disclosed is a method for controlling the evolution of photo-responsive systems (including chemical species, biochemical species or material compounds) using a device capable of producing shaped incoherent light for such control. The disclosed device integrates a polychromatic incoherent source in an adaptive feedback control loop.

Abstract: Apparatus for analysing molecules, including an ablation device 1,10 for releasing molecules from a sample, and a laser device 1,2,3 for illuminating released molecules with a shaped laser pulse thereby to ionize and/or dissociate the molecules. The ablation device or laser device has at least one component which is not shared by the other device. This enables the steps of ablation and ionization/dissociation to be separated. The ablation device may be means for generating an ion or neutral beam, or an unshaped laser pulse. The laser device may be a femtosecond shaped pulse laser. The ablation device may illuminate the sample with a beam and the laser device preferably produces a pulse shaped laser beam which is spaced part from the sample.

Abstract: Techniques for molecular scale discrimination using functional data are provided. A method for molecular scale discrimination using functional data can include, for example, (a) applying a control pulse to excite one or more molecular species in a molecular scale system, (b) collecting functional data for an observable variable from the molecular scale system after the control pulse is applied in (a), (c) adjusting the control pulse under the control of a closed loop controller, for dynamically discriminating one of a plurality of molecular species in the molecular scale system from another molecular species in the molecular scale system, and repeating (a) and (b) with the adjusted control pulse, and (d) discriminating the one molecular species from the other molecular species in the molecular scale system, by using the collected functional data.

Abstract: A closed-loop method for optimally identifying a system structure by determinig the relationship between control settings and system response for at least one function of the system, within which at least one system component produces a change in the form of a measurable system response, wherein the method includes the steps of (1) operating the system through one or more control settings to produce a system response; (2) collecting the system response data; (3) inverting the system response data with a globally searching inversion algrithm and determining the distribution of inverted system structures consistent therewith; (4) analyzing the distribution of inverted system structures with a learning algorithm and determining one or more new control settings that will reduce the distribution of inverted system structures; and (5) interactively repeating the steps of the method using the newest control settings, until the distribution of inverted system structures cannot be further reduced.

Abstract: A method for accelerating searches for optimal control of photonic reagents is provided. Closed loop feedback is applied to control a quantum system. A direct search deterministic technique is used for refining said closed loop feedback control. A quantum system controller is also provided.

Abstract: The disclosed invention is related to the field of quantum dynamic discriminators, sample identification systems, mass spectrometers and methods for identifying a component in a composition. Also disclosed are quantum dynamic discriminators and methods for ascertaining the quantum dynamic states of a component in a composition. Optimal identification devices and methods for ascertaining quantum Hamiltonians of quantum systems are further disclosed.

Abstract: A method for the selective variation of a multi-variable molecular synthesis to optimize a reaction product functional property, including the steps of: constructing a first order library of functional property output data obtained by reacting all first order library input variable combinations for the multi-variable synthesis and measuring the functional property for every reaction product, wherein the first order library input variable combinations include all values selected for each variable taken one at a time; ordering the values for each input variable according to their effect upon functional property optimization; constructing a second order library of functional property output data obtained by reacting a set of second order library input variable combinations coarsely sampled two variables at a time from the ordered input variables and measuring the functional property for every reaction product; and interpolating among the functional property output data for functional property optimization.

Abstract: A flow reactor providing a high degree of selectivity in the reaction of a feedstock to produce one or more end product compounds, which includes: side walls defining an elongated reactor unit having a length dimension along which the feedstock is reacted under varying conditions of energy and chemical flux effective to produce the one or more end product compounds; a plurality of devices for supplying energy or chemical flux through the side walls and positioned to distribute the energy and chemical flux along the length of the reactor unit so as to optimize a property of the one or more end product compounds; devices for measuring a property of the end product compounds; and an adaptive feedback control system to determine, establish and maintain the optimum energy and chemical flux distribution along the length of the reactor based on the end product property measurement.